Eisenmangel und Eisenprophylaxe bei Blutspendern

Heinrich, H. C.; Oppitz, K. H.; Busch, H

doi:10.1007/bf01483914

“…Since depletion of iron deposits may occur without anemia, iron deficiency may go undetected in many blood donors. The incidence is about 10% [9,14].…”

Section: Introductionmentioning

confidence: 99%

Serum Ferritin in the Regulation of Iron Therapy in Blood Donors

Birgegård

¹

,

Högman

²

,

Johansson

³

et al. 1980

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12 regular blood donors were selected on the basis of subnormal serum ferritin levels as a criterion for iron deficiency. It was found that all had high transferrin levels but only 5 had subnormal serum iron or transferrin saturation. The donors were given oral iron therapy in a dose of 2,800 mg between each phlebotomy, and the donation interval was standardized to 8 weeks. Test samples were collected every 4th week. After an initial rise in ferritin during the first 2 months, 6 of the donors again had subnormal serum ferritin levels, and the iron dose was therefore doubled after 32 weeks. Following this, all subjects taking the higher dose had normal ferritin values and stainable marrow iron was found at the end of the study, after 92 weeks. 3 subjects did not take the higher dose, had no raised serum ferritin level or stainable hemosiderin. It is concluded that serum ferritin estimation can be used to monitor the therapy in blood donors so that a satisfactory amount of iron is stored.

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“…absorption and iron stores, they have led to general recommendations concerning fre quency of phlebotomies and iron therapy without regard to individual variation [2,4,8,9,12,13]. This has been necessary, since none of the methods mentioned above is simple enough for routine use.…”

Section: Introductionmentioning

confidence: 99%

Serum Ferritin Levels in Male Blood Donors

Birgegård¹,

Högman²,

Killander³

et al. 1978

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Serum ferritin estimation has been shown to be a reliable test to reveal iron deficiency. Such estimations have been made in groups of male blood donors with a varying number of previous phlebotomies and a mean interval between donations of 9.9 ±1.7 SD weeks. It was found that the mean ferritin level was significantly (p<0.001) lower in the blood donors than in nondonors. After 6-8 phlebotomies it was about 40% lower. Subnormal ferritin values were found in 10% of the donors, almost exclusively among those who had taken less than 1,000 mg of iron supplementation since the last donation. It is concluded that with a donation interval of about 10 weeks, there is a considerable risk for iron deficiency after about 6 donations. This risk is far less if more than 1,000 mg of iron supplementation is taken between phlebotomies. A role for serum ferritin estimation in monitoring donation intervals and/or iron therapy is suggested.

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“…The final dose of iron was relatively high in comparison to those generally recom mended to blood donors [9,14,15]. The present study was not designed to provide a basis for general recommendations but it can be concluded that previous recommenda tions of 1,200-2,000 mg of iron between donations are inadequate for some blood donors.…”

Section: Discussionmentioning

confidence: 84%

“…It is a well-known fact that the measure ment of Hb concentration in blood donors is not a guarantee against iron depletion [9,14,16]. The most sensitive methods for es-certain that the donors in the present study actually took the iron, we carefully explain ed the idea of the study to each one of them.…”

Section: Discussionmentioning

confidence: 99%

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Serum Ferritin in the Regulation of Iron Therapy in Blood Donors

Birgegård¹,

Högman²,

Johansson³

et al. 1980

View full text Add to dashboard Cite

12 regular blood donors were selected on the basis of subnormal serum ferritin levels as a criterion for iron deficiency. It was found that all had high transferrin levels but only 5 had subnormal serum iron or transferrin saturation. The donors were given oral iron therapy in a dose of 2,800 mg between each phlebotomy, and the donation interval was standardized to 8 weeks. Test samples were collected every 4th week. After an initial rise in ferritin during the first 2 months, 6 of the donors again had subnormal serum ferritin levels, and the iron dose was therefore doubled after 32 weeks. Following this, all subjects taking the higher dose had normal ferritin values and stainable marrow iron was found at the end of the study, after 92 weeks. 3 subjects did not take the higher dose, had no raised serum ferritin level or stainable hemosiderin. It is concluded that serum ferritin estimation can be used to monitor the therapy in blood donors so that a satisfactory amount of iron is stored.

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Eisenmangel und Eisenprophylaxe bei Blutspendern

Cited by 19 publications

References 12 publications

Serum Ferritin in the Regulation of Iron Therapy in Blood Donors

Serum Ferritin in the Regulation of Iron Therapy in Blood Donors

Serum Ferritin Levels in Male Blood Donors

Serum Ferritin in the Regulation of Iron Therapy in Blood Donors

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