Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2

Burnett, Arthur L.; Johns, Devin G.; Kriegsfeld, Lance J.; Klein, Sabra L.; Calvin, David; Demas, Gregory E.; Schramm, Lawrence P.; Tonegawa, Susumu; Nelson, Randy J.; Snyder, Solomon H.; Poss, Kenneth D.

doi:10.1038/nm0198-084

Cited by 110 publications

(70 citation statements)

References 16 publications

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“…Importantly, phenotypical alterations in the only known human case of genetic HO-1 deficiency are highly similar to those observed in HO-1 knockout mice [13]. By contrast, HO-2 deficient mice have an intact immune system, but exhibit major neurological defects [14]. Independently, targeted overexpression of HO-1 has been shown to have beneficial effects in various experimental animal models of inflammation [2,15].…”

Section: Introductionmentioning

confidence: 83%

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

Paine

Eiz‐Vesper

Blasczyk

et al. 2010

Biochemical Pharmacology

649

503

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Section: Introductionmentioning

confidence: 83%

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

Paine

Eiz‐Vesper

Blasczyk

et al. 2010

Biochemical Pharmacology

649

503

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“…163 Hem ereksiyonun kontrolü hem de regülasyonunda rolü olduğu gösterilmiştir. 164 CO, anjiyogenezi arttırmaktadır. Bunu HIF-1α' yı aktive ederek yapmaktadır.…”

Section: Santral Si̇ni̇r Si̇stemi̇ Patoloji̇leri̇nde Hi̇drojen Sülfür İle İlunclassified

Gas Mediators in the Nervous System: Nitric Oxide, Hydrogen Sulfide and Carbon Monoxide

Nomenoğlu¹,

Yılmaz²

2017

Turkiye Klinikleri J Neur

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“…CO may also have a transmitter role in the vas deferens where it is localized to neuronal populations that regulate ejaculation (Burnett et al 1998). Ejaculatory reflexes mediated by the bulbospongiosus muscle are abolished in HO2 Ϫ / Ϫ mice, and ejaculation is markedly diminished in intact HO2…”

Section: Carbon Monoxidementioning

confidence: 99%

Heme Oxygenase A Font of Multiple Messengers

Snyder

2001

Neuropsychopharmacology

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Neurotransmitters and related messenger molecules abound in the brain with numbers ranging between 50 and 100 depending on who is doing the counting. Their chemical structures vary from peptides and large proteins to metal ions such as zinc and the diatomic gases nitric oxide (NO) and carbon monoxide (CO). Most are formed by enzymatic processing although there are notable exceptions. The neurotransmitter pool of zinc comes from a zinc transporter that concentrates the metal into synaptic vesicles together with glutamate. Neurotransmitter pools of amino acids are probably sequestered largely by transporters although this is not altogether clear. For the most part, neurotransmitter peptides are not generated by selective enzymes but by generalized peptide-processing enzyme systems. Highly selective neurotransmitter forming enzymes exist for the biogenic amines; for D-serine, which is formed by serine racemase that converts L-serine to D-serine ; for NO, generated from arginine by NO synthase (NOS); and for CO, formed from heme by heme oxygenase (HO). In most cases the biosynthetic enzyme or series of enzymes yield a single end product. For instance, tryptophan hydroxylase coupled with aromatic amino acid decarboxylase is solely concerned with forming serotonin, while tyrosine hydroxylase, aromatic amino acid decarboxylase, and dopamine betahydroxylase together generate norepinephrine. The focus of this essay is a notable exception. Heme oxygenase gives rise to three discrete products, CO, ferrous iron and biliverdin-bilirubin. Only recently has there been an appreciation that all three of these products have important physiologic roles which may be complementary. CARBON MONOXIDEHO was first identified as an enzyme that degrades heme in aging red blood cells. The enzyme was highly concentrated in the spleen, the graveyard of erythrocytes. It is induced by heme, enabling it to respond to hemolysis or tissue destruction, which releases heme from mitochondrial enzymes. Maines and associates Trakshel et al. 1986) identified a second enzyme, which is not inducible and is most highly concentrated in the brain and testes. The non-inducible enzyme is designated HO2, while the inducible form is HO1.Following the identification of NO as a neurotransmitter, we wondered whether there might exist other gaseous transmitter molecules and explored CO as a possibility. If CO were a transmitter, a form of HO, presumably HO2, should be localized to neurons. In situ hybridization reveals HO2 in discrete neuronal populations in the brain with localizations closely resembling those of soluble guanylyl cyclase (Verma et al. 1993). CO as well as NO can bind to and activate guanylyl cyclase, which is presumably their second messenger. HO2 localizations in the brain resemble soluble guanylyl cyclase better than the localizations of NO synthase. In olfactory neuronal cultures inhibition of HO2 depletes cyclic GMP levels while inhibition of NO synthase is without effect (Verma et al. 1993;Ingi and Ronnett 1995;Ingi et al. 1996).Direct evidenc...

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Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2

Cited by 110 publications

References 16 publications

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

Gas Mediators in the Nervous System: Nitric Oxide, Hydrogen Sulfide and Carbon Monoxide

Heme Oxygenase A Font of Multiple Messengers

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