IntroductionMagnetic resonance imaging of the heart for measurements of right and left ventricular volumes is well validated at a field strength of 1.5 T [1, 2, 3], usually using extensive hardware equipment such as phased-array surface coils and gradient systems enabling high slew rates for minimizing image acquisition time. Different MR techniques have been tested such as spin-echo (SE) imaging and gradient cine MR imaging [4,5]. More recently, several authors compared ultrafast multishot or single-shot echo-planar imaging (EPI) to conventional gradient techniques of the heart, demonstrating markedly shorter acquisition times without significant loss of temporal and spatial resolution enabling adequate delineation of the endocardial borders comparable to gradient cine MRI, and permitting breath-hold imaging [6,7,8,9]. Ventricular volumes and ejection fractions are important measurements of cardiac function, e. g., for obtaining prognostic indicators in patients with different relevant cardiac diseases [4] and frequently used parameters central to the objective characterization of cardiac performance [7].The aim of this study was to enhance the capability of a commercially available software for the determination of right and left ventricular volume measurements using an animal heart model in vitro on a standard MR system at 1.0 T before applying this method in patients. To our knowledge, in most in vivo and in vitro studies, 1.5-T magnets as well as power gradients and special surface coils have been used in cardiac MR volumetry. A gradient EPI technique (multishot EPI) was used combining a short acquisition time and evaluable images of good quality.
Materials and methods
Heart modelsEight pig hearts were explanted and immediately perfused with cardiopelagic solution (Bretschneider solution) over the aortic root. The atria were removed followed by water-tight sew-up of the atrioventricular valves. Cannulas were fixed into the aorta and the pulmonary truncus. Coronary arteries were perfused with Abstract. The aim of this study was to determine the accuracy in quantifying right and left ventricular volumes using a 1.0-T system and commercially available, standard equipment. For exact comparison of MRI measurements and real volumes we used an animal heart model ex vivo. Eight pig hearts were explanted and prepared by removal of the atria. Aorta and pulmonary truncus were cannulated. Definable volumes were injected into the ventricles. Magnetic resonance imaging was performed at 1.0 T (Gyroscan T10 NT, Philips, Eindhoven, The Netherlands); sequence: fast field echo±echo planar (multishot EPI); body coil; MR software: Cardiac Application Package (Philips). Statistical analysis correlated the real volumes and MR measurements separately for both ventricles and two investigators (SAS, ANOVA). For both ventricles and both investigators the correlation between real volumes and MR measurements was greater than 0.99. There was no significant systematic false estimation for both ventricles. Magnetic resonance imaging at 1.0...