Sever al studies have examined the correlation and agreement between noninvasive measurement of ejection fraction (EF) and that derived with left ventricular (LV) angiography. [1][2][3][4] The noninvasive modalities include echocardiography, radionuclide methods, and magnetic resonance imaging. 5 Echocardiography has been widely used for the evaluation of EF as it is readily available and relatively less expensive than other techniques. M-mode derivations of EF are wrought with errors in patients with technically difficult studies and regional wall motion abnormalities. Simpson's biplane method is nearly reliable, but again is highly dependent on good endocardial border definition. 6 Although quantitative echocardiography methods are available, visual estimation is known to provide good information to experienced echocardiographers. 7 Intracardiac opacification (contrast) agents are now being used more frequently and allow better visualization of LV cavity and endocardial boundaries. 3 In this issue of Clinical Medicine & Research, present a retrospective analysis of determination of EF in 534 patients from a single institution who had undergone LV angiography, echocardiography, and nuclear perfusion imaging. They excluded patients who had testing occurring more than 30 days apart. For echocardiography, Simpson's two-dimensional methodology was utilized for deriving left ventricular ejection fraction (LVEF). This method is most helpful for obtaining LV volumes when the LV geometry is distorted. 6 Radionuclide determination of EF was performed with a single-dose of technetium-99m Sestamibi (Cardiolite). LV angiography was acquired by the single plane method. The endocardial borders of the left ventricle were traced manually by carefully outlining the ventricular silhouette and then converting to area.Combined LV angiography and echocardiography studies were performed on 202 patients. Similarly, combined single photon emission computed tomography (SPECT) studies and echocardiographic studies were performed on 201 patients. For both groups, studies were performed within 1 month of each other. The results, showing that LVEFs obtained by echocardiography were significantly lower than those obtained by angiography, were consistent with a previous report. 9 The correlation coefficient was significant (r = 0.70, P<0.0001). When comparing SPECT to LV angiography, the correlation coefficient was also significant (r = 0.69, P<0.0001).