EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways

Tsay, Huey Jen; Liu, Hui Kang; Kuo, Yueh‐Hsiung; Chiu, Chuan Sheng; Liang, Chih Chiang; Chung, Chen Wei; Chen, Chin Chu; Chen, Yen Po; Shiao, Young‐Ji

doi:10.3390/ijms221910413

Cited by 15 publications

(12 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Developing animal models of human illnesses is a challenging task for translational research, but it is indispensable to understanding pathomechanism, searching for biomarkers, and engineering novel treatment [ 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 ]. Migraine research is no exception.…”

Section: Animal Models Of Neurogenic Inflammationmentioning

confidence: 99%

Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research

et al. 2021

View full text Add to dashboard Cite

Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing headache, which lasts for hours to days, and the pain can interfere with daily activities. It exhibits various symptoms, such as nausea, vomiting, sensitivity to light, sound, and odors, and physical activity consistently contributes to worsening pain. Despite the intensive research, little is still known about the pathomechanism of migraine. It is widely accepted that migraine involves activation and sensitization of the trigeminovascular system. It leads to the release of several pro-inflammatory neuropeptides and neurotransmitters and causes a cascade of inflammatory tissue responses, including vasodilation, plasma extravasation secondary to capillary leakage, edema, and mast cell degranulation. Convincing evidence obtained in rodent models suggests that neurogenic inflammation is assumed to contribute to the development of a migraine attack. Chemical stimulation of the dura mater triggers activation and sensitization of the trigeminal system and causes numerous molecular and behavioral changes; therefore, this is a relevant animal model of acute migraine. This narrative review discusses the emerging evidence supporting the involvement of neurogenic inflammation and neuropeptides in the pathophysiology of migraine, presenting the most recent advances in preclinical research and the novel therapeutic approaches to the disease.

show abstract

Section: Animal Models Of Neurogenic Inflammationmentioning

confidence: 99%

Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The residues are suspended in water before being partitioned with n-hexane and ethyl acetate. Antrodin C is isolated from the ethyl acetate fraction by subsequent chromatography on silica gel and Sephadex LH-20 columns [ 77 ]. The semipreparative HPLC may increase the purity of antrodin C. A semipreparative HPLC column (Waters XBridge C18 column, Φ19 × 250 mm 2 , 5 µm) is used to separate crude antrodin C. The mobile phase comprises distilled water H 2 O (0.5% acetic acid) and acetonitrile (34851, Sigma–Aldrich) (10 mL/min) to obtain antrodin C with a purity exceeding 95% [ 73 ].…”

Section: Isolation and Purification Of Bioactive Compounds From ...mentioning

confidence: 99%

Review of Bioactivity, Isolation, and Identification of Active Compounds from Antrodia cinnamomea

Wang

et al. 2022

Bioengineering

View full text Add to dashboard Cite

Antrodia cinnamomea is a precious and popular edible and medicinal mushroom. It has attracted increasing attention due to its various and excellent bioactivities, such as hepatoprotection, hypoglycemic, antioxidant, antitumor, anticancer, anti-inflammatory, immunomodulation, and gut microbiota regulation properties. To elucidate its bioactivities and develop novel functional foods or medicines, numerous studies have focused on the isolation and identification of the bioactive compounds of A. cinnamomea. In this review, the recent advances in bioactivity, isolation, purification, and identification methods of active compounds from A. cinnamomea were summarized. The present work is beneficial to the further isolation and discovery of new active compounds from A. cinnamomea.

show abstract

“…Recent studies have analyzed specific natural or synthetic compounds that can modulate M1/M2 microglial polarization and suggested that they can serve as potential therapeutic agents for NDs. Furthermore, studies documenting the impact of the microbiome on microglial polarization have also been reported [47][48][49].…”

Section: Microglial Polarization As An Inflammation/anti-inflammation...mentioning

confidence: 99%

Roles of Fatty Acids in Microglial Polarization: Evidence from In Vitro and In Vivo Studies on Neurodegenerative Diseases

Sanjay

Park

Lee

2022

IJMS

View full text Add to dashboard Cite

Microglial polarization to the M1 phenotype (classically activated) or the M2 phenotype (alternatively activated) is critical in determining the fate of immune responses in neurodegenerative diseases (NDs). M1 macrophages contribute to neurotoxicity, neuronal and synaptic damage, and oxidative stress and are the first line of defense, and M2 macrophages elicit an anti-inflammatory response to regulate neuroinflammation, clear cell debris, and promote neuroregeneration. Various studies have focused on the ability of natural compounds to promote microglial polarization from the M1 phenotype to the M2 phenotype in several diseases, including NDs. However, studies on the roles of fatty acids in microglial polarization and their implications in NDs are a rare find. Most of the studies support the role of polyunsaturated fatty acids (PUFAs) in microglial polarization using cell and animal models. Thus, we aimed to collect data and provide a narrative account of microglial types, markers, and studies pertaining to fatty acids, particularly PUFAs, on microglial polarization and their neuroprotective effects. The involvement of only PUFAs in the chosen topic necessitates more in-depth research into the role of unexplored fatty acids in microglial polarization and their mechanistic implications. The review also highlights limitations and future challenges.

show abstract

EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways

Cited by 15 publications

References 64 publications

Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research

Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research

Review of Bioactivity, Isolation, and Identification of Active Compounds from Antrodia cinnamomea

Roles of Fatty Acids in Microglial Polarization: Evidence from In Vitro and In Vivo Studies on Neurodegenerative Diseases

Contact Info

Product

Resources

About