Domestic water consumption accounts for a large share of urban water demand. The present study discusses a study on domestic water consumption in ten different neighborhoods in Vijayawada, India. The study examines the relationship between per capita water consumption and various socio-economic, physical, and supply-related variables. The study conducted a primary survey of 117 households to collect data on water consumption and related factors. Multiple regression analysis was used to identify the significant determinants of per capita water consumption. The study found that supply continuity, household size, household income, building height, building age, and annual water charges significantly affect per capita water consumption in the studied neighborhoods. The study also found that different types of neighborhoods have different per capita water consumption levels and determinants. The study results assist urban planners and local bodies in systematically managing water demands through spatial and policy solutions. The study identifies that urban planners and local bodies can manage water demands through effective spatial and policy solutions.