Ekstrak Kelopak Rosella Merah (Hibiscus sabdariffa Linn.) Mampu Memperbaiki Histopatologi Hepar Tikus Wistar yang Diberi Paparan Asap Rokok

Abstract

Abstrak Prevalensi penduduk di Indonesia usia merupakan salah satu sumber radikal bebas. rosella merah terhadap degenerasi hepatosit tikus dan dibagi menjadi empat kelompok rosella merah dosis 270 mg/bw, kontrol positif dan kontrol negatif. Kelompok per rosella dipagi hari dan setelah itu dipapar 2 rokok per hari. Kontrol positif diberi pakan standar + dipapar 2 rokok per hari. Kontrol negatif hanya diberi pakan standar. Penelitian gambaran histopatologi hepar. Pemberian ekstrak kelopak rosella merah dosis 270 mg/kg bb dan dosis 540 mg/kg bb dapat mencegah degenerasi hepatosit. Analisis degenerasi hepatosit dilakukan uji lanjut Mann-Whitney. memperbaiki degenerasi hepatosit tikus wistar yang diberi paparan asap rokok. Kata kunci: antioksidan, rosella merah, radikal bebas, asap rokok, degenerasi hepatosit AbstractThe population prevalence in Indonesia one of free radical sources. The objective of t degeneration of Wistar rat hepatocytes exposed to cigarette smoke. Total sample four groups: the treatment of red rosella petal extract with dose of 540 mg/bw, red rosella petal extract with dose of 270 mg/bw, positive control and negative c and then, it was exposed to two cigarettes per day. Positive control was fed standard + exposed cigarettes per day.Negative control was only feed standard. This study was conduc analyzed picture of hepatic histopathology. The giving of red rosella petal extract with dose of 270 mg/kg bw and a dose of 540 mg/kg bw can prevent degeneration of hepatocytes. Analysis of degeneration of h Wallis test with p<0.05 and continued with the Mann prevent, and even can improve Wistar rat hepatocytes degeneration exposed to cigarette smoke.

The influence of roselle-based wedang uwuh (Hibiscus sabdariffa L.) on SOD (superoxide dismutase) and MDA (malondialdehyde) of cigarette smoke-exposed rat

“…Several studies have shown that roselle effectively lowers blood pressure, lowers fat profile, has antiinflammatory, antimicrobial, anti-anaemia, anticarcinogenic, hepatoprotective, and improves fertility disorder (Riaz and Chopra, 2018). Another study showed that roselle extract prevented the increase in MDA (Ulilalbab et al, 2015); thus preventing and improving rat hepatocyte degeneration in rats exposed to cigarette smoke (Ulilalbab et al, 2018).…”