El aceite de oliva virgen y la distribución y movimiento transmembrana del colesterol en la membrana de eritrocito humano

Muriana, Francisco J.G.; Gutiérrez, V. Ruíz

doi:10.3989/gya.1998.v49.i2.713

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…Also, recent studies have revealed that ingesting olive oil normalizes the asymmetric distribution of cholesterol on the inner and outer walls of erythrocyte membranes as well as their motion inside, thereby significantly reducing blood pressure in hypertensive individuals. [4][5][6] In order to get an insight into the mechanism of action of olive oil on cholesterol, we undertook studies herein on the surface behavior of its unsaturated fatty acids (OA and LA) in the presence of cholesterol. To this end, we used the monolayer technique which provides an excellent in vitro model for cell membranes.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, a diet rich in olive oil and some fish meat, which contain unsaturated fatty acids and may thus help to reduce the incidence of vascular accidents such as myocardial infarction, has strongly been advised by nutritionists. Also, recent studies have revealed that ingesting olive oil normalizes the asymmetric distribution of cholesterol on the inner and outer walls of erythrocyte membranes as well as their motion inside, thereby significantly reducing blood pressure in hypertensive individuals. − …”

Section: Introductionmentioning

confidence: 99%

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Thermodynamic and Brewster Angle Microscopy Studies of Fatty Acid/Cholesterol Mixtures at the Air/Water Interface

Seoane¹,

Miñones²,

Conde³

et al. 2000

J. Phys. Chem. B

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Mixtures of cholesterol with stearic (STA), oleic (OA), and linoleic (LA) acids spread as monolayers at the air/water interface were used as model systems to examine the hypocholesterolemic effect of fatty acids. Miscibility and interactions between the components of the cholesterol/fatty acid systems were studied basing on the analysis of surface pressure/area isotherms completed with Brewster angle microscopy images. In monolayers, STA and cholesterol were found to be immiscible. In contrast, OA and LA were found to form miscible, but nonideal mixed monolayers with cholesterol. They exhibit negative deviations from ideality in the surface pressure/area plots. This reflects close-packing arrangements between bulky cholesterol molecule and the hydrocarbon chains of unsaturated fatty acids. The analysis of the excess free energies of mixing shows that the maximum negative value of ΔG exc appears at about X chol = 0.5−0.7. Thus, the formation of the most stable 1:1 and 2:1 complexes between cholesterol and an unsaturated fatty acid molecule may account for the hypocholesterolemic effect of the acids in human organism by complexing free cholesterol, thereby hindering its deposition on artery walls.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%