“…11 In clinical practice, the most common way to evaluate afterload is by calculating the systemic or pulmonary vascular resistance (VR), which offers information on vascular tone. 12 It is important to take into account that the arterial VR value only represents opposition or resistance to a constant flow, which is found fundamentally at arteriolar level, where the compensating mechanisms that control vasomotor tone keep the perfusion pressure within a physiological range. In this context, a complete description of global arterial impedance is not provided, due to the fluctuating nature of blood flow and arterial pressure.…”