El Prognostic Nutritional Index predice la morbilidad postoperatoria tras la cirugía curativa del cáncer colorrectal

Bailón-Cuadrado, Martín; Pérez-Saborido, B.; Sánchez‐González, Javier; Rodríguez-López, M.; Velasco-López, Rosalía; Sarmentero-Prieto, José C.; Blanco-Álvarez, José I.; Pacheco-Sánchez, D.

doi:10.1016/j.ciresp.2018.08.015

Cited by 16 publications

(7 citation statements)

References 44 publications

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“…Whether a single cancer-specific nutritional screening tool is more specific should be discussed. For example, Onodera's prognostic nutritional index has been used for evaluating malnutrition in gastrointestinal cancer patients [33][34][35]. In addition, in our study, the cancer-specific NUTRISCORE did not show better performance than the MST, which only included weight loss and decreased appetite.…”

Section: Discussionmentioning

confidence: 45%

Validation of the efficacy of the NUTRISCORE for the nutritional screening of cancer patients in China

Kang

Shi

et al. 2022

BMC Cancer

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Background Malnutrition is common in cancer patients. The NUTRISCORE is a newly developed cancer-specific nutritional screening tool and was validated by comparison with the Patient-Generated Subjective Global Assessment (PG-SGA) and Malnutrition Screening Tool (MST) in Spain. We aimed to evaluate the performance of the NUTRISCORE, MST, and PG-SGA in estimating the risk of malnutrition in Chinese cancer patients. Methods Data from an open parallel and multicenter cross-sectional study in 29 clinical teaching hospitals in 14 Chinese cities were used. Cancer patients were assessed for malnutrition using the PG-SGA, NUTRISCORE, and MST. The sensitivity, specificity, and areas under the receiver operating characteristic curve were estimated for the NUTRISCORE and MST using the PG-SGA as a reference. Results A total of 1000 cancer patients were included. The mean age was 55.9 (19 to 92 years), and 47.5% were male. Of these patients, 450 (45.0%) had PG-SGA B and C, 29 (2.9%) had a NUTRISCORE ≥5, and 367 (36.7%) had an MST ≥ 2. Using the PG-SGA as a reference, the sensitivity, specificity, and area under the curve values of the NUTRISCORE were found to be 6.2, 99.8%, and 0.53, respectively. The sensitivity, specificity, and area under the curve values of the MST were 50.9, 74.9%, and 0.63, respectively. The kappa index between the NUTRISCORE and PG-SGA was 0.066, and that between the MST and PG-SGA was 0.262 (P < 0.05). Conclusions The NUTRISCORE had an extremely low sensitivity in cancer patients in China compared with the MST when the PG-SGA was used as a reference.

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Section: Discussionmentioning

confidence: 45%

Validation of the efficacy of the NUTRISCORE for the nutritional screening of cancer patients in China

Kang

Shi

et al. 2022

BMC Cancer

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“…Whether a single cancer-speci c nutritional screening tool is more speci c should be discussed. For example, the Onodera's prognostic nutritional index had been used for evaluating malnutrition in gastrointestinal cancer patients [32][33][34]. Besides, in our study, the cancer-speci c NUTRISCORE did not have better performance than MST, which only include weight loss and decreased appetite.…”

Section: Discussionmentioning

confidence: 53%

Validation of the Efficacy of the NUTRISCORE for Nutritional Screening of Cancer Patients in China

Kang

Shi

et al. 2021

Preprint

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Background: Malnutrition is common in cancer patients. The NUTRISCORE was a newly developed cancer-specific nutritional screening tool and validated by reference to the Patient-Generated Subjective Global Assessment (PG-SGA) and Malnutrition Screening Tool (MST) in Spain. We aimed to evaluate the performance of NUTRISCORE, MST, and PG-SGA in estimating the risk of malnutrition in Chinese cancer patients.Methods: Data from an open parallel and multicenter cross-section study in 29 clinical teaching hospitals in 14 Chinese cities were used. Cancer patients were assessed for malnutrition using PG-SGA, NUTRISCORE, and MST. The sensitivity, specificity, and areas under the receiver operating characteristic curve were estimated for NUTRISCORE and MST using PG-SGA as a reference.Results: A total of 1000 cancer patients were included. The mean age was 55.9 (19 to 92 years), and 47.5% were male. 450 patients (45.0%) had PG-SGA B and C, 29 patients (2.9%) had a NUTRISCORE ≥ 5, and 367 patients (36.7%) had MST ≥ 2. With PG-SGA as a reference method, the sensitivity, specificity, and area under the curve values of the NUTRISCORE was 6.2 %, 99.8%, and 0.53, respectively. The sensitivity, specificity, and area under the curve values of the MST were 50.9%, 74.9%, and 0.63, respectively. The kappa index between NUTRISCORE and the PG-SGA were 0.066 and 0.262 between MST and the PG-SGA (P < 0.05).Conclusions: NUTRISCORE was found a higher specificity and lower sensitivity compared with MST using PG-SGA as a reference method in cancer patients in China. Further studies are needed.

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“…More and more researchers are paying attention to the prevention and early treatment of CRC. 3 One of the hot areas of multidisciplinary crossdisciplinary research is "diet, nutrition and cancer". Polyunsaturated fatty acids (PUFAs) have become a hot spot in medical research as an "immune nutrient".…”

Section: Introductionmentioning

confidence: 99%

<p>Omega-3PUFA Attenuates MNU-Induced Colorectal Cancer in Rats by Blocking PI3K/AKT/Bcl-2 Signaling</p>

Huang

Chun-an

Cai

et al. 2020

OTT

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Background: Omega 3 polyunsaturated fatty acid (Omega-3PUFA) is one of the essential nutrients for human body involved in intracellular metabolic regulation and cell signaling. Previous studies have shown that Omega-3PUFA is involved in the pathogenesis of digestive system tumors, including colorectal cancer (CRC), however, the effects of Omega-3PUFA on CRC has not been fully elucidated. In the current study, we evaluated whether Omega-3PUFA can alleviate N-methyl-N-nitrosourea(MNU) induced CRC in a rat model and illustrated the potential mechanism. Methods: The effects of Omga-3PUFA on MNU-induced colorectal cancer in rats were analyzed by in vivo experiments. The viability, apoptosis, colony formation and invasion of CRC cells treated with Omga-3PUFA were detected by CCK8, flow cytometry, clone formation assay and transwell invasion assay. The expression of apoptosis-related proteins in CRC cells treated with Omga-3PUFA was detected by Western blotting. Finally, after adding PI3K activator, the viability, apoptosis and protein expression of CRC cells treated with Omga-3PUFA were detected by CCK8, flow cytometry and Western blotting. Results: Our results showed that Omega-3PUFA attenuated MNU-induced CRC in rats and inhibited AKT/Bcl-2 signaling in rats. In addition, Omega-3PUFA inhibited CRC cell proliferation and induces CRC cell apoptosis. Moreover, Omega-3PUFA inhibited CRC cell colony formation and invasion, and inhibited PI3K/AKT/Bcl-2 signaling in CRC cells. Furthermore, The effects of Omega-3PUFA on cell proliferation and apoptosis were inhibited by blocking PI3K/AKT signaling. Conclusion: Omega-3PUFA can attenuate MNU-induced colorectal cancer in rats by blocking PI3K/AKT/Bcl-2 signaling, which suggests that Omega-3PUFA may be a potent agent for CRC treatment.

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El Prognostic Nutritional Index predice la morbilidad postoperatoria tras la cirugía curativa del cáncer colorrectal

Cited by 16 publications

References 44 publications

Validation of the efficacy of the NUTRISCORE for the nutritional screening of cancer patients in China

Validation of the efficacy of the NUTRISCORE for the nutritional screening of cancer patients in China

Validation of the Efficacy of the NUTRISCORE for Nutritional Screening of Cancer Patients in China

<p>Omega-3PUFA Attenuates MNU-Induced Colorectal Cancer in Rats by Blocking PI3K/AKT/Bcl-2 Signaling</p>

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