¿El volumen medio plaquetario es un es un predictor de mortalidad en pacientes sépticos? Revisión de la literatura

Vélez, Jorge Luis

doi:10.20453/rmh.v29i2.3353

Cited by 4 publications

(5 citation statements)

References 6 publications

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“…Several studies have demonstrated the predictive utility of MPV in sepsis 9,[11][12][13][14][15][16][17][18][19][20][21][22][23][24] however;, there is little reported bibliography that compares platelet kinetics in critically ill patients with and without sepsis, a critical situation to be demonstrated since several non-infectious diseases can also potentially increase platelet size.…”

Section: Discussionmentioning

confidence: 99%

The behavior of Mean Platelet Volume in Sepsis in critical patients with and without sepsis

Páez¹,

Páez

2021

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The mean platelet volume is an anatomical biomarker that has shown its usefulness in various cardiovascular and metabolic pathologies; in sepsis, it has been positioning itself as an indicator of mortality, easily accessible and immediately applicable when reported in the routine blood count. This study demonstrates the mean platelet volume's biological behavior in critical patients with sepsis compared with non-septic patients. An observational, longitudinal, prospective, monocentric cohort study was conducted in 250 patients treated at the intensive care unit of the Pablo Arturo Suárez Hospital, Quito- Ecuador, from January 2019 January 2020. A group of patients with sepsis (n = 125) and without infectious pathologies (n = 125) were studied. The inclusion criteria were patients over 18 years of age of both genders, diagnosed with sepsis or septic shock using SEPSIS 3 criteria, and patients without septic pathology. The mean platelet volume (MPV) of days 1, 2, and 3 were studied. Septic patients had a mean APACHE (18.74 SD 9.52) higher than the non-septic ones (11.93 SD 7.01) (p = < 0.000). The MPV was consistently higher in patients with sepsis than non-septic patients, but it reached statistical significance on day 3 (9.13 SD 1.55 vs. 8.66 SD 1.34, p=0.042). The MPV on day 3 presented a significant area under the curve (AUC =0.580) (CI. 0.500-0.661), where the cut-off point according to Youden's index was positive for sepsis if MPV≥ 9.85 femtoliter (fL) with OR=3.30 and p-value= 0.005. Likewise, lactate on admission showed an AUC of 0.625 (CI. 0.555-0.694), with a cut-off point ≥of 1.15 mmol / L, OR=2.51, and p=0.007. Age and hypertension did not show a multivariate relationship with the presence of sepsis. It was shown that MPV is higher in patients with sepsis compared to non-septic ones. This observation reaches significance on day 3. Additionally, elevated lactate at admission was also associated with a septic state. On the other hand, platelet count did not show the expected behavior.

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Section: Discussionmentioning

confidence: 99%

The behavior of Mean Platelet Volume in Sepsis in critical patients with and without sepsis

Páez¹,

Páez

2021

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“…19 Aunque la evaluación de rutina de los parámetros plaquetarios ha estado disponible desde hace muchos años, su importancia clínica no se ha aclarado por completo y su uso diagnóstico ha sido limitado, el volumen medio plaquetario como indicador temprano de infección de origen bacteriano de fácil acceso y bajo costo ha representado durante los últimos años una posible herramienta alternativa coadyuvante para el diagnóstico de sepsis, mejorando así su pronóstico. 6 Esto se plantea en los estudios realizados por el seguimiento de los pacientes, principalmente por el Instituto Klinikum St. Georg en el 2012, Chan en el 2015, Sánchez en 2016 y Vélez en el 2017; que dieron seguimiento del recuento plaquetario en sus respectivos estudios, descubrieron que los picos de cambio en el VMP se realizan comparativamente respecto a su fecha de ingreso al día tres (explicado por el curso de la enfermedad) y en el día siete (máximo pico de cambio en el tamaño en sus respectivos estudios).…”

Section: Sars-cov Mers-cov Y Sars-cov-2 (Betaco-unclassified

“…4 Un biomarcador anatómico poco utilizado, pero reportado en los hemogramas rutinarios, es el volumen medio plaquetario (VMP), que ha demostrado su utilidad en el pronóstico de estados inflamatorios-trombóticosmetabólicos como eventos isquémicos cerebrales y cardiacos. [6][7][8] En el pasado, su uso se limitaba al diagnóstico de alteraciones plaquetarias inusuales; no obstante, en la actualidad ha adquirido gran importancia en patología clínica. 6,9,10 La detección temprana de sepsis progresiva sería útil como estratificación del riesgo, monitoreando la progresión de la enfermedad y la eficacia terapéutica.…”

Section: Introductionunclassified

“…[6][7][8] En el pasado, su uso se limitaba al diagnóstico de alteraciones plaquetarias inusuales; no obstante, en la actualidad ha adquirido gran importancia en patología clínica. 6,9,10 La detección temprana de sepsis progresiva sería útil como estratificación del riesgo, monitoreando la progresión de la enfermedad y la eficacia terapéutica. 11 Aunque los estudios recientes han intentado identificar biomarcadores prometedores que pueden predecir severidad y mortalidad en las primeras etapas de la sepsis, no hay actualmente ningún factor pronóstico que puede predecir severidad y mortalidad en las etapas tempranas de la sepsis.…”

Section: Introductionunclassified

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Volumen medio plaquetario como biomarcador de respuesta inflamatoria y su utilidad como indicador temprano de mortalidad en pacientes con COVID-19

Flores¹,

Martínez²

2022

Medicina Crítica

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Volumen medio plaquetario como biomarcador de respuesta inflamatoria y su utilidad como indicador temprano de mortalidad en pacientes con COVID-19Median platelet volume as a biomarker of inflammatory response and it's utility as an early indicator of mortality in patients with COVID-19 Volume medio de plaquetas como biomarcador de resposta inflamatória e sua utilidade como indicador precoce de mortalidade em pacientes com

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“…The mean platelet volume (MPV) is the size of platelets measured through automated blood biometry [ 7 ], which normal value is 8.81 +/− 1.68 fL [ 8 , 9 ]. This marker reflects the presence of young platelets in the blood, probably due to megakaryocyte hyperproliferation in the bone marrow [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume as a Predictor of COVID-19 Severity: A Prospective Cohort Study in the Highlands of Peru

et al. 2022

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Introduction: Although 80% of symptomatic individuals with COVID-19 develop mild forms, it is the severe (15%) and critical (5%) forms that have the greatest impact in the hospital setting. Recognizing markers that can predict severe forms is essential, especially in high-altitude populations. Methods: We conducted a prospective cohort study at 3200 masl (meters above sea level) in a city in Peru to determine if MPV (mean platelet volume) level is a predictor of COVID-19 severity. Patients with mild/moderate disease were enrolled and followed for 21 days or until the development of severe disease (primary outcome). A bivariate analysis was used to identify variables associated with severe disease. A ROC analysis determined the best MPV (mean platelet count) cut-off to predict COVID-19 severity, and then, a multiple regression analysis was performed. Results: 64 patients were enrolled. The median age was 48.5 years (IQT 39–64.5) and the proportion of women was 51.6%, the most frequent symptoms were chest pain (73%), fever (71%), and dyspnea (67%). The median time to develop a severe form from the onset of symptoms was 11 days (IQT 10.5–13). The most common radiographic phase on CT scan (computed tomography) was progressive (60.38%). We observed that an MPV of more than 10.15 fL in the first week of disease predicted severity regardless of age and sex at high altitudes. Conclusions: MPV in the first week of the disease may predict severity in patients diagnosed with COVID-19 at high altitudes; however, we need prospective studies with a larger population and at a different altitude, levels to confirm these findings.

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¿El volumen medio plaquetario es un es un predictor de mortalidad en pacientes sépticos? Revisión de la literatura

Cited by 4 publications

References 6 publications

The behavior of Mean Platelet Volume in Sepsis in critical patients with and without sepsis

The behavior of Mean Platelet Volume in Sepsis in critical patients with and without sepsis

Volumen medio plaquetario como biomarcador de respuesta inflamatoria y su utilidad como indicador temprano de mortalidad en pacientes con COVID-19

Mean Platelet Volume as a Predictor of COVID-19 Severity: A Prospective Cohort Study in the Highlands of Peru

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