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Spicer, Patrick T.; Small, William; Lynch, Matthew L.; Burns, Janet L.

doi:10.1023/a:1021184216308

Cited by 127 publications

(58 citation statements)

References 35 publications

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“…To date, PILs have not received a particularly large share of the literature based on ILs studies [16]. Nevertheless, these ILs family have many useful properties and potential applications [16], often arising from their protic nature, including as self-assembly media [17][18][19][20][21], reaction media and catalysts for organic reactions [22][23][24], biological applications [25][26][27][28], as proton conducting electrolytes for polymer membrane fuel cells [29][30][31], and as explosives [31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Volumetric properties, viscosity and refractive index of the protic ionic liquid, pyrrolidinium octanoate, in molecular solvents

Anouti

Vigeant

Jacquemin

et al. 2010

The Journal of Chemical Thermodynamics

140

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a b s t r a c tDensities (q) and viscosities (g) of binary mixtures containing the Protic Ionic Liquid (PIL), pyrrolidinium octanoate with five molecular solvents: water, methanol, ethanol, n-butanol, and acetonitrile are determined at the atmospheric pressure as a function of the temperature and within the whole composition range. The refractive index of all mixtures (n D ) is measured at 298.15 K. The excess molar volumes V E and deviation from additivity rules of viscosities g E and refractive index D / n, of pyrrolidinium octanoate solutions were then deduced from the experimental results as well as apparent molar volumes V/ i , partial molar volumes V m;i and thermal expansion coefficients a p . The excess molar volumes V E are negative over the entire mole fraction range for mixture with water, acetonitrile, and methanol indicating strong hydrogen-bonding interaction for the entire mole fraction. In the case of longest carbon chain alcohols (such as ethanol and n-butanol) + pyrrolidinium octanoate solutions, the V E variation as a function of the composition describes an S shape. The deviation from additivity rules of viscosities is negative over the entire composition range for the acetonitrile, methanol, ethanol, and butanol, and becomes less negative with increasing temperature. Whereas, g E of the {[Pyrr][C 7 CO 2 ] + water} binary mixtures is positive in the whole mole fraction range and decreases with increasing temperature. the excess Gibbs free energies of activation of viscous flow (DG* E ) for these systems were calculated. The deviation from additivity rules of refractive index D / n are positive over the whole composition range and approach a maximum of 0.25 in PIL mole fraction for all systems. The magnitude of deviation for D / n describes the following order: water > methanol > acetonitrile > ethanol. Results have been discussed in terms of molecular interactions and molecular structures in these binary mixtures.

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Section: Introductionmentioning

confidence: 99%

Volumetric properties, viscosity and refractive index of the protic ionic liquid, pyrrolidinium octanoate, in molecular solvents

Anouti

Vigeant

Jacquemin

et al. 2010

The Journal of Chemical Thermodynamics

140

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“…It was suggested to use the common conventional emulsification methods (such as ultrasonication, microfluidization, and homogenization) for the fragmentation and the stabilization of these monoglyceride selfassembled systems [1,11,[21][22][23][24]. Another emulsification method, introduced by Spicer and coworkers [25,26], for the formation of stable cubosome dispersions is called the dilution process and is based on a minimal energy input as well as a spontaneous formation of cubosomes in the presence of ethanol. This emulsification method has been modified by Jeong and coworkers [27,28].…”

Section: Introductionmentioning

confidence: 99%

“…A recent method for the formation of cubosomes and hexosomes with narrow particle size distributions and good colloidal stabilities is based on the application of microfluidization followed by a heat treatment at 125 • C [29,30]. The content of the dispersed hydrophobic phase (monoglycerides plus oil) available by such procedures up to now are reported to be in the typical range of 1-15 wt% [1,11,[21][22][23][24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Preparation of highly concentrated nanostructured dispersions of controlled size

Salentinig

Yaghmur

Guillot

et al. 2008

Journal of Colloid and Interface Science

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“…A second process was also developed to allow cubosome production from a powdered precursor. 24) Spray-dried powders comprising monoolein coated with starch or dextran form cubosomes on simple hydration. The polymers immediately provide colloidal stabilization of the cubosomes.…”

mentioning

confidence: 99%

Cubosomes: An Overview

Garg

Saraf

2007

Biological & Pharmaceutical Bulletin

236

151

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Surfactant and polymers are generally used in the controlled drug delivery systems. Surfactant and polymer systems form supra-assemblies, which are extensively exploited as active delivery vehicles. These systems include liquid crystalline aggregates (e.g., liposomes and cubosomes) or cross-linked gel networks (hydrogels) that load, stabilize, and eventually deliver active ingredients. The potential for utilizing a particular active with a vehicle depends on the physicochemical properties of both. To achieve therapeutic effects, it must be possible to load sufficient amounts of the active, which largely depends on the interaction of the vehicle and active. Further, the integrity of the active must be retained through all stages: preparation, storage, and use. The release rate of actives must be controlled to achieve optimal drug release profiles, while ease of preparation and vehicle stability must also be considered. An optimal delivery vehicle must successfully encompass all these properties.Cubosomes are bicontinuous cubic phase liquid crystals have many properties that make them appealing as a universal vehicle for drug delivery. Luzzati et al. 1) first documented its geometric model supplied later by Scriven.2) Which is in the past decade have been examined for drug delivery.3) The surfactant assembles into bilayers that are twisted into a three dimension, periodic, minimal surface forming tightly packed structure, like "honeycombed" with bicontinuous domains of water and lipid.Cubosome particles are first prepared by mechanical fragmentation of the cubic lipid-water phase in a three-phase region containing a liposomal dispersion and to differentiate from liposomes, these particles have been termed as cubosomes. [4][5][6][7][8] Its structure is different from liposomes because its structure can simultaneously accommodate water-soluble, lipid-soluble, and amphiphilic molecules.Three structure of cubosomes have been proposed by Luzzati et al. 9); (i) Pn3m (D-surface) (Diamond surface), (ii) Ia3d (G-surface) (Gyroid surface), and (iii) Im3m (P-surface) (Primitive surface), in terms of nodal surfaces.The structure generally maintains the efficacy; stability of actives such as vitamins 10) and proteins. 11) Cubosomes are thermodynamically stable; lasting indefinitely.12) Colloidal dispersions of cubosomes can be stabilized by the addition of polymers.13) They also possess the potential for controlled delivery of actives, where diffusion is governed by the tortuous diffusion of the active through the "regular" channel structure of the cubic phase.14) Cubosomes possess a sufficient average degree of molecular orientation order to characterize by structural symmetry, and often form in aqueous surfactant system at relatively high ampiphile concentrations.History Luzzati and Husson 15) and Luzzati et al. first recognized the existence of cubic phases in lipid-water system using X-ray scattering measurement. Fontell et al. 16) drew similar conclusions regarding cubic phase in ternary systems of ampiphiles, oils and ...

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Cited by 127 publications

References 35 publications

Volumetric properties, viscosity and refractive index of the protic ionic liquid, pyrrolidinium octanoate, in molecular solvents

Volumetric properties, viscosity and refractive index of the protic ionic liquid, pyrrolidinium octanoate, in molecular solvents

Preparation of highly concentrated nanostructured dispersions of controlled size

Cubosomes: An Overview

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