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Guil‐Guerrero, José Luis; Belarbi, EI-Hassan; Rebolloso-Fuentes, M.M.

doi:10.1023/a:1011124624001

Cited by 55 publications

(21 citation statements)

References 19 publications

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“…Some studies have focused on the suitability of this species as a source of highly pure EPA, using various extraction processing and purification protocols [93,94]. Another potential source of EPA-rich oils is the diatom Odontella aurita Agardh, which may contain around 26%–28% EPA in its fatty acid profile [94] and is currently approved for use as a food supplement [95], which could facilitate the acceptance of the oil as an ingredient in the market.…”

Section: Microalgae As Sources Of N-3 Lc-pufamentioning

confidence: 99%

Alternative Sources of n-3 Long-Chain Polyunsaturated Fatty Acids in Marine Microalgae

et al. 2013

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The main source of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) in human nutrition is currently seafood, especially oily fish. Nonetheless, due to cultural or individual preferences, convenience, geographic location, or awareness of risks associated to fatty fish consumption, the intake of fatty fish is far from supplying the recommended dietary levels. The end result observed in most western countries is not only a low supply of n-3 LC-PUFA, but also an unbalance towards the intake of n-6 fatty acids, resulting mostly from the consumption of vegetable oils. Awareness of the benefits of LC-PUFA in human health has led to the use of fish oils as food supplements. However, there is a need to explore alternatives sources of LC-PUFA, especially those of microbial origin. Microalgae species with potential to accumulate lipids in high amounts and to present elevated levels of n-3 LC-PUFA are known in marine phytoplankton. This review focuses on sources of n-3 LC-PUFA, namely eicosapentaenoic and docosahexaenoic acids, in marine microalgae, as alternatives to fish oils. Based on current literature, examples of marketed products and potentially new species for commercial exploitation are presented.

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Section: Microalgae As Sources Of N-3 Lc-pufamentioning

confidence: 99%

Alternative Sources of n-3 Long-Chain Polyunsaturated Fatty Acids in Marine Microalgae

et al. 2013

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“…Arachidonic acid (ARA, 20:4n6) is a long-chain PUFA (LCPUFA) belonging to the n-6 family. This molecule is the precursor of the biosynthetic pathway leading to the production of prostaglandin PGE2, thromboxanes and other metabolites involved in the regulation of various physiological processes, e.g., inflammation and immune function [6]. Docosahexaenoic acid (DHA, 22:6n3) is one of the predominant LCPUFAs in the structural phospholipids of the human brain and retina, and it accumulates within the fetal neural tissue during pregnancy and the postnatal period [7].…”

Section: Introductionmentioning

confidence: 99%

SWATH Differential Abundance Proteomics and Cellular Assays Show In Vitro Anticancer Activity of Arachidonic Acid- and Docosahexaenoic Acid-Based Monoacylglycerols in HT-29 Colorectal Cancer Cells

et al. 2019

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Colorectal cancer (CRC) is one of the most common and mortal types of cancer. There is increasing evidence that some polyunsaturated fatty acids (PUFAs) exercise specific inhibitory actions on cancer cells through different mechanisms, as a previous study on CRC cells demonstrated for two very long-chain PUFA. These were docosahexaenoic acid (DHA, 22:6n3) and arachidonic acid (ARA, 20:4n6) in the free fatty acid (FFA) form. In this work, similar design and technology have been used to investigate the actions of both DHA and ARA as monoacylglycerol (MAG) molecules, and results have been compared with those obtained using the corresponding FFA. Cell assays revealed that ARA- and DHA-MAG exercised dose- and time-dependent antiproliferative actions, with DHA-MAG acting on cancer cells more efficiently than ARA-MAG. Sequential window acquisition of all theoretical mass spectra (SWATH)—mass spectrometry massive quantitative proteomics, validated by parallel reaction monitoring and followed by pathway analysis, revealed that DHA-MAG had a massive effect in the proteasome complex, while the ARA-MAG main effect was related to DNA replication. Prostaglandin synthesis also resulted as inhibited by DHA-MAG. Results clearly demonstrated the ability of both ARA- and DHA-MAG to induce cell death in colon cancer cells, which suggests a direct relationship between chemical structure and antitumoral actions.

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“…The presence of eicosapentaenoic (C20:5ω-3), EPA 3.5 ± 0.9%, and docosahexaenoic (C22:6ω-3), DHA 1.7 ± 0.3%, polyunsaturated fatty acids (PUFAs) in the particular algal biomass is worth mentioning. Although the major sources of both acids EPA and DHA, on a worldwide basis, are still marine fish, microalgae and cyanobacteria, exhibiting competitive advantages as sources of PUFAs because fish have typically lower contents (on a mass basis), are subject to seasonal variations in fatty acid profile, and may be significantly contaminated with heavy metals owing to pollution throughout the food chain [57,58]. Besides confirming the appropriateness of some cyanobacteria for wide use as feed in the aquaculture industry, they have been used for functional food formulation aimed at therapeutically enhanced and nutritional features [59].…”

Section: Discussionmentioning

confidence: 99%

Solving Nuisance Cyanobacteria Eutrophication Through Biotechnology

Orfanidis¹,

Stamatis²,

Parasyri

et al. 2019

Applied Sciences

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Management of nutrient inputs and usage of nuisance biomass as feedstock for bioenergy may be the solution of coastal lagoons eutrophication. We studied the species composition, photosynthetic pigments (Chl-a and Chl-c) and performance (OJIP-kinetics and JIP-test parameters), biochemistry (lipids and carbohydrates composition), and hydrogen production potential of Limnoraphis (Lyngbya) nuisance biomass collected from Lafri lagoon (1.24 km2) in Greece. The results showed that the removal of algal biomass from Lafri lagoon before its sedimentation, characterized by low Fν/Fm (0.42) and PItotal (2.67) values, and transfer of this in a simple, closed bioreactor, has the potential to produce hydrogen (H2), a renewable CO2-neutral energy that can directly be converted into electricity. The free carbohydrates of the lagoon water and that from the algal cells (42g glucose analogs per m3) could be also transferred to alcohols (biofuels), while the rest of the biomass could be used as organic fertilizer. The total lipid content (2.51%) of dry biomass composed primarily by palmitic acid was low. However, the presence of eicosapentaenoic (3.5%), and docosahexaenoic (1.7%), polyunsaturated fatty acids is worth mentioning. By harvesting and conversion of this coastal lagoon nuisance algal biomass to energy or other products, one could improve its water quality and, therefore, biodiversity and fish production; that is a sustainable solution of eutrophication necessary for the ongoing climatic change.

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Cited by 55 publications

References 19 publications

Alternative Sources of n-3 Long-Chain Polyunsaturated Fatty Acids in Marine Microalgae

Alternative Sources of n-3 Long-Chain Polyunsaturated Fatty Acids in Marine Microalgae

SWATH Differential Abundance Proteomics and Cellular Assays Show In Vitro Anticancer Activity of Arachidonic Acid- and Docosahexaenoic Acid-Based Monoacylglycerols in HT-29 Colorectal Cancer Cells

Solving Nuisance Cyanobacteria Eutrophication Through Biotechnology

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