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Todorovic, Mirjana; Jensen, Erik Weber; Thøgersen, C

doi:10.1023/a:1016903508976

Cited by 17 publications

(4 citation statements)

References 7 publications

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“…A planecta port is useful to avoid babbling and/or bacterial contamination [ 10 ], but it decreases the natural frequency of the kit. ROSE™ is useful to optimise the frequency characteristics of the kits with no or one planecta port [ 11 , 12 ]. However, the kit with two planecta ports showed underdamping, and when ROSE™ was inserted, it showed overdamping due to the very low natural frequency.…”

Section: Discussionmentioning

confidence: 99%

Effect of planecta and ROSE™ on the frequency characteristics of blood pressure-transducer kits

Fujiwara

Kawakubo

Mori

et al. 2014

J Clin Monit Comput

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Pressure-transducer kits have frequency characteristics such as natural frequency and damping coefficient, which affect the monitoring accuracy. The aim of the present study was to investigate the effect of planecta ports and a damping device (ROSE™, Argon Medical Devices, TX, USA) on the frequency characteristics of pressure-transducer kits. The FloTrac sensor kit (Edwards Lifesciences, CA, USA) and the DTXplus transducer kit (Argon Medical Devices) were prepared with planecta ports, and their frequency characteristics were tested with or without ROSE™. The natural frequency and damping coefficient of each kit were obtained using frequency characteristics analysis software and evaluated by plotting them on the Gardner’s chart. By inserting a planecta port, the natural frequency markedly decreased in both the FloTrac sensor kit (from 40 to 22 Hz) and the DTXplus transducer kit (from 35 to 22 Hz). In both kits with one planecta port, the damping coefficient markedly increased by insertion of ROSE™ from 0.2 to 0.5, optimising frequency characteristics. In both kits with two planecta ports, however, the natural frequency decreased from 22 to 12 Hz. The damping coefficient increased from 0.2 to 0.8 by insertion of ROSE™; however, optimisation was not achieved even by ROSE™ insertion. Planecta ports decrease the natural frequency of the kit. ROSE™ is useful to optimise the frequency characteristics in the kits without or with one planecta port. However, optimisation is difficult with two or more planecta ports, even with the ROSE™ device.

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Section: Discussionmentioning

confidence: 99%

Effect of planecta and ROSE™ on the frequency characteristics of blood pressure-transducer kits

Fujiwara

Kawakubo

Mori

et al. 2014

J Clin Monit Comput

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“…In our previous studies, we demonstrated that the nanocomposite hydrogels containing Mg 2+ effectively enhanced the osteogenic differentiation of hMSCs and contributed to in situ bone regeneration . By further investigating the functions of Mg 2+ in cellular metabolism, we noticed that it is also a critical cofactor for the enzymatic activity of alkaline phosphatase (ALP) . ALP catalyzes the hydrolysis of monoesters of phosphoric acid to generate inorganic phosphate, which is essential for bone mineralization .…”

Section: Introductionmentioning

confidence: 99%

Adaptable Hydrogels Mediate Cofactor‐Assisted Activation of Biomarker‐Responsive Drug Delivery via Positive Feedback for Enhanced Tissue Regeneration

et al. 2018

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The targeted and simultaneous delivery of diverse cargoes with vastly different properties by the same vehicle is highly appealing but challenging. Here, a bioactive nanocomposite hydrogel based on hyaluronic acid and self‐assembled pamidronate‐magnesium nanoparticles for the localized elution and on‐demand simultaneous release of bioactive ions and small molecule drugs is described. The obtained nanocomposite hydrogels exhibit excellent injectability and efficient stress relaxation, thereby allowing easy injection and consequent adaptation of hydrogels to bone defects with irregular shapes. Magnesium ions released from the hydrogels promote osteogenic differentiation of the encapsulated human mesenchymal stem cells (hMSCs) and activation of alkaline phosphatase (ALP). The activated ALP subsequently catalyzes the dephosphorylation (activation) of Dex phosphate, a pro‐drug of Dex, and expedites the release of Dex from hydrogels to further promote hMSC osteogenesis. This positive feedback circuit governing the activation and release of Dex significantly enhances bone regeneration at the hydrogel implantation sites. The findings suggest that these injectable nanocomposite hydrogels mediate optimized release of diverse therapeutic cargoes and effectively promote in situ bone regeneration via minimally invasive procedures.

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“…However, the use of multiple FTPs in the circuit causes a marked reduction in the natural frequency, resulting in underdamping of kit circuits and undershooting of the arterial intra-arterial pressure waveform [3]. In contrast, the insertion of the ROSE TM system considerably increases the damping coefficient of the circuits and subsequently decreases underdamping [7,8]. However, overdamping was still observed when two FTPs and the ROSE TM system were combined [3].…”

Section: Discussionmentioning

confidence: 99%

Effect of using a Planecta™ port with a three-way stopcock on the natural frequency of blood pressure transducer kits

Fujiwara

Tachihara

Mori

et al. 2015

J Clin Monit Comput

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Blood pressure transducer kits are equipped with two types of Planecta™ ports-the flat-type Planecta™ port (FTP) and the Planecta™ port with a three-way stopcock (PTS). We reported that FTP application decreased the natural frequency of the kits. However, Planecta™ is an invaluable tool as it prevents infection, ensures technical simplicity, and excludes air. Hence, an ideal Planecta™ port that does not decrease the frequency characteristics is required. As a first step in this direction, we aimed to assess the influence of PTSs on the natural frequency of blood transducer kits. A DTXplus transducer kit (DT4812J; Argon Medical Devices, TX, USA) was used along with ≥1 PTSs (JMS, Hiroshima, Japan), and the frequency characteristics were assessed. The natural frequency and damping coefficient of each kit were obtained by using frequency characteristics analysis software, and these parameters were evaluated by plotting them on Gardner's chart. Regardless of whether one or two PTSs were inserted, the natural frequency of the kits only slightly decreased (from 42.5 to 41.1 Hz, when 2 PTSs were used). Thus, the frequency characteristics of the kits with PTSs were adequate for pressure monitoring. The insertion of ≥2 FTPs in pressure transducer kits should be avoided, as they markedly decrease the natural frequency and lead to underdamping. However, the effect of PTS insertion in pressure transducer kits on the frequency characteristics is minimal. Thus, we found that the use of PTS markedly improved the frequency characteristics as compared to the use of FTP.

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Untitled

Cited by 17 publications

References 7 publications

Effect of planecta and ROSE™ on the frequency characteristics of blood pressure-transducer kits

Effect of planecta and ROSE™ on the frequency characteristics of blood pressure-transducer kits

Adaptable Hydrogels Mediate Cofactor‐Assisted Activation of Biomarker‐Responsive Drug Delivery via Positive Feedback for Enhanced Tissue Regeneration

Effect of using a Planecta™ port with a three-way stopcock on the natural frequency of blood pressure transducer kits

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