Elaborating piperazinyl-furopyrimidine based scaffolds as phosphoinositol-3-kinase enzyme alpha (PI3Kα) inhibitors to combat pancreatic cancer

Abstract

Phosphoinositol-3-kinase alpha (PI3K-α) enzyme inhibition to combat pancreatic cancer.

Design, Synthesis and Biological Evaluation of 6-(Imidazo[1,2-a]pyridin-6-yl)quinazoline Derivatives as Anticancer Agents via PI3Kα Inhibition

“…It has shown that the anti-proliferative activity of PI3Kα inhibitors was associated with cell cycle arrest [ 42 ]. Therefore, we examined the effects of 13k on cell cycle distribution.…”

Divergent copper-catalyzed syntheses of 3-carboxylpyrroles and 3-cyanofurans from O-acetyl oximes and β-ketoesters/nitriles

“…To our knowledge, this represents the first synthesis of furans from oxime esters. 20 3-Cyanofurans are useful blocks for synthesizing complex molecules 21 and have shown interesting UV-absorbing properties; 22 thus, the development of novel protocols to access those heterocycles is an attractive goal. 23 When the transformation was applied to the formerly synthesized oximes 1 and others oxime esters, these molecules reacted with 2b to provide a wide range of furans in a more efficient fashion than was observed in the corresponding syntheses of pyrroles described above (Table 3).…”