Single crystal fibers combine the great specific surface area of fibers and the single crystal property of the bulk crystal which shows great potential for a high-power laser. For an Er-doped crystal, due to the fluorescence quenching at the 3 μm wavelength, high Er doping is necessary to increase the fluorescent up-conversion for the breaking limitation. However, a high Er doping concentration must lead to high heat accumulation, resulting in poor laser performance. Compared with an Er-doped bulk crystal, Er-doped SCF has the great potential to remove the heat in the crystal, and it is easy to obtain a high power. In this paper, Er: Y3Sc2Ga3O12 (Er: YSGG) single crystals were successfully grown using the micro-pulling-down method (μ-PD). Owing to the stably grown interface, the diameter of the crystal is 2 mm with a length up to 80 mm. Then, the measurements of Laue spots and Er3+ distribution indicated that our crystals have a high quality. Based on the as-prepared Er: YSGG SCF, the continuous-wave (CW) laser operations at 2794 nm were realized. The maximum output was 166 mW with a slope efficiency of up to 10.99%. These results show that Er: YSGG SCF is a suitable material for future high-power 3 μm laser operation.