Elastic constants identification of irregular hard biological tissue materials using FEM-based resonant ultrasound spectroscopy

Wang, Rui; Fan, Fan; Zhang, Qiang; Li, Xiaoming; Niu, Haijun; Laugier, Pascal

doi:10.1016/j.jmbbm.2019.04.031

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…The cardiotoxicity caused by chronic smoking may suggest the toxicity induced by nicotinic derivatives, because some studies such as the one by Wang et al . revealed myocardiotoxicity through experimentation with cardiomyocytes derived from pluripotential stem cells [ 28 ], so that the administration of cytisine at low doses (50 µM) has cytotoxic effects, increasing oxidative stress and calcium homeostasis, and causing functional changes in cardiomyocytes [ 28 ]. The cardiotoxicity of nicotinic derivatives makes it necessary to evaluate a proposal for the treatment for smoking cessation based on their safety.…”

Section: Resultsmentioning

confidence: 99%

Potential uses of cytisine for smoking cessation in menopausal women – literature summary

Rubio¹,

Martínez²,

Zarzuelo³

2023

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Introduction Menopause is a vital stage in which the risk of the appearance of metabolic syndrome and cardiovascular diseases is increased. Cardiovascular risk in menopausal women must be monitored because it is one of the most common causes of mortality in these women. Smoking is an important risk factor for the development of many diseases, including cardiovascular diseases, so promoting smoking cessation in these women is important for the maintenance of cardiovascular health. Material and methods Current smoking cessation programs mainly include nicotine and varenicline as therapeutic agents, due to their history of success, safety, and efficacy in aiding in cessation, but they do not include “new” agents such as cytisine as coadjuvant in the elimination of the habit of smoking. Results Cytisine is a therapeutic agent traditionally used in Eastern Europe, which has demonstrated efficacy and safety in smoking cessation, also showing other new pharmacological actions. It has been widely used since World War II as a nicotine substitute. Conclusions These pharmacological actions, together with their efficacy in smoking cessation, should be explored to evaluate the convenience of the use of cytisine in premenopausal and postmenopausal women, so that cytisine can be identified as a useful therapeutic tool in smoking cessation programs and in particular in menopausal women.

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Section: Resultsmentioning

confidence: 99%

Potential uses of cytisine for smoking cessation in menopausal women – literature summary

Rubio¹,

Martínez²,

Zarzuelo³

2023

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“…occurring far from typical working conditions. Ultrasonic techniques, in particular resonant ultrasound spectroscopy (RUS) [27,28], have successfully helped to determine and investigate the macroscopic mechanical properties on several biological samples including wood [29,30], bones [31,32], or the human skull [33], also in combination with micro-computed tomography (μCT) scans and finite element analysis (FEA) [34], while nano and microscale characterizations are also fundamental to address the same properties at smaller length scales [35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Multiscale static and dynamic mechanical study of the Turritella terebra and Turritellinella tricarinata seashells

Liu

Lott

et al. 2023

J. R. Soc. Interface.

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Marine shells are designed by nature to ensure mechanical protection from predators and shelter for molluscs living inside them. A large amount of work has been done to study the multiscale mechanical properties of their complex microstructure and to draw inspiration for the design of impact-resistant biomimetic materials. Less is known regarding the dynamic behaviour related to their structure at multiple scales. Here, we present a combined experimental and numerical study of the shells of two different species of gastropod sea snail belonging to the Turritellidae family, featuring a peculiar helicoconic shape with hierarchical spiral elements. The proposed procedure involves the use of micro-computed tomography scans for the accurate determination of geometry, atomic force microscopy and nanoindentation to evaluate local mechanical properties, surface morphology and heterogeneity, as well as resonant ultrasound spectroscopy coupled with finite element analysis simulations to determine global modal behaviour. Results indicate that the specific features of the considered shells, in particular their helicoconic and hierarchical structure, can also be linked to their vibration attenuation behaviour. Moreover, the proposed investigation method can be extended to the study of other natural systems, to determine their structure-related dynamic properties, ultimately aiding the design of bioinspired metamaterials and of structures with advanced vibration control.

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“…These are, for example, fast-moving objects on conveyor belts, hot materials or specimens that cannot be surface contaminated. The NCUS methodology is also handled in the study of biological and medical preparations (Yamamoto et al, 2018;Wang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Elasticity investigation of thin cellular structure films for piezoelectric sensors

Klimiec

Zachariasz

Kaczmarek

et al. 2021

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Purpose This paper aims to present the details of isotactic polypropylene (it-PP) films with a cellular structure (air-cavities) dedicated to pressure sensors. The polymer composites (thin films enriched with 5 and 10 wt% of mineral fillers as Sillikolloid P 87 and glass beads) should exhibit suitable structural elasticity within specific stress ranges. After the deformation force is removed, the sensor material must completely restore its original shape and size. Design/methodology/approach Estimating the stiffness tensor element (C33) for polymer films (nonpolar space-charge electrets) by broadband resonance ultrasound spectroscopy is a relatively simple method of determining the safe stress range generated in thin pressure sensors. Therefore, ultrasonic and piezoelectric studies were carried out on four composite it-PP films. First, the longitudinal velocity (vL) of ultrasonic waves passing through the it-PP film in the z-direction (thickness) was evaluated from the ω-position of mechanical resonance of the so-called insertion loss function. In turn, the d33 coefficient was calculated from accumulated piezoelectric charge density response to mechanical stress. Findings Research is at an early stage; however, it can be seen that the mechanical orientation of the it-PP film improves its piezoelectric properties. Moreover, the three-year electric charge stability of the it-PP film seems promising. Originality/value Ultrasonic spectroscopy can be successfully handled as a validation method in the small-lot production of polymer films with the air-cavities structure intended for pressure sensors. The structural repeatability of polymer films is strongly related to a homogeneous distribution of the electric charge on the electret surface.

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Elastic constants identification of irregular hard biological tissue materials using FEM-based resonant ultrasound spectroscopy

Cited by 7 publications

References 25 publications

Potential uses of cytisine for smoking cessation in menopausal women – literature summary

Potential uses of cytisine for smoking cessation in menopausal women – literature summary

Multiscale static and dynamic mechanical study of the Turritella terebra and Turritellinella tricarinata seashells

Elasticity investigation of thin cellular structure films for piezoelectric sensors

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