Elastic electronics based on micromesh-structured rubbery semiconductor films

Guan, Ying‐Shi; Ershad, Faheem; Ke, Zhifan; Costa, Ernesto Curty da; Xiang, Qian; Lu, Yuntao; Wang, Xu; Mei, Jianguo; Vanderslice, Peter; Hochman-Mendez, Camila; Yu, Cunjiang

doi:10.1038/s41928-022-00874-z

Cited by 39 publications

(28 citation statements)

References 44 publications

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“…In this context, various soft implantable bioelectronics with high conformability and reliable mechanical/electrical performances have been developed for cardiac diagnosis and treatment, with a focus on cardiac arrhythmias. − Among various implantable electronics, soft cardiac interfacing devices (e.g., implantable cardiac pacemakers) are generally regarded as a prevailing platform for aberrant heart rates or rhythms. , Stretchable conductive nanocomposites have emerged as a promising material for the diagnosis and treatment of heart failure and myocardial infarction owing to their mechanical softness, long-term biocompatibility in vivo , sensing, and therapy performance. − For instance, a stretchable conductive nanocomposite was fabricated using Ag–Au–Pt core–shell–shell nanowires and in situ formed Pt nanoparticles dispersed in styrene-ethylene–butadiene-styrene substrates for cardiac arrhythmias therapy (Figure a) . The Ag–Au–Pt nanocomposite electrode can be attached to a dynamically beating rat heart to treat cardiac arrhythmias (Figure b).…”

Section: Implantable Therapeutic Bioelectronicsmentioning

confidence: 99%

Soft Bioelectronics for Therapeutics

Zhang,

Zhu,

Zhou

et al. 2023

ACS Nano

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Soft bioelectronics play an increasingly crucial role in high-precision therapeutics due to their softness, biocompatibility, clinical accuracy, long-term stability, and patient-friendliness. In this review, we provide a comprehensive overview of the latest representative therapeutic applications of advanced soft bioelectronics, ranging from wearable therapeutics for skin wounds, diabetes, ophthalmic diseases, muscle disorders, and other diseases to implantable therapeutics against complex diseases, such as cardiac arrhythmias, cancer, neurological diseases, and others. We also highlight key challenges and opportunities for future clinical translation and commercialization of soft therapeutic bioelectronics toward personalized medicine.

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Section: Implantable Therapeutic Bioelectronicsmentioning

confidence: 99%

Soft Bioelectronics for Therapeutics

Zhang,

Zhu,

Zhou

et al. 2023

ACS Nano

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“…3D flexible electronics manufactured through mechanically-guided methods have emerged as promising tools for in vivo monitoring of physiological signals for living organisms, such as tissues and organs. ,,,,,,− For example, 3D piezoelectric microsystems (Figure a) were fabricated for implantable monitoring of muscle activities (e.g., trotting and climbing), providing platforms for in vivo biological interactions without obvious irritations or mechanical constraints . Other 3D forms with high stretchabilities were exploited in wireless skin-compatible electronic sensors, enabling the tracking of spatial motions and the monitoring of electrophysiological signals .…”

Section: Applicationsmentioning

confidence: 99%

Mechanically-Guided 3D Assembly for Architected Flexible Electronics

Bo,

Xu,

Yang

et al. 2023

Chem. Rev.

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Architected flexible electronic devices with rationally designed 3D geometries have found essential applications in biology, medicine, therapeutics, sensing/imaging, energy, robotics, and daily healthcare. Mechanically-guided 3D assembly methods, exploiting mechanics principles of materials and structures to transform planar electronic devices fabricated using mature semiconductor techniques into 3D architected ones, are promising routes to such architected flexible electronic devices. Here, we comprehensively review mechanically-guided 3D assembly methods for architected flexible electronics. Mainstream methods of mechanically-guided 3D assembly are classified and discussed on the basis of their fundamental deformation modes (i.e., rolling, folding, curving, and buckling). Diverse 3D interconnects and device forms are then summarized, which correspond to the two key components of an architected flexible electronic device. Afterward, structure-induced functionalities are highlighted to provide guidelines for function-driven structural designs of flexible electronics, followed by a collective summary of their resulting applications. Finally, conclusions and outlooks are given, covering routes to achieve extreme deformations and dimensions, inverse design methods, and encapsulation strategies of architected 3D flexible electronics, as well as perspectives on future applications.

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“…The traditional ways to monitor detailed heart and cardiac status rely on bulky and professional equipment such as cardiac ultrasound, electrocardiograph, and intravenous cannula (23)(24)(25)(26) and require patients to go to the hospital, hindering timely diagnosis and precise treatment. With the development of modern society and the growth in personalized medical demand, portable and intelligent systems for real-time, precise, and longterm cardiovascular monitoring are highly desired (27)(28)(29)(30)(31)(32)(33).…”

Section: Introductionmentioning

confidence: 99%

Monitoring blood pressure and cardiac function without positioning via a deep learning–assisted strain sensor array

Li,

Wang,

et al. 2023

Sci. Adv.

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Continuous and reliable monitoring of blood pressure and cardiac function is of great importance for diagnosing and preventing cardiovascular diseases. However, existing cardiovascular monitoring approaches are bulky and costly, limiting their wide applications for early diagnosis. Here, we developed an intelligent blood pressure and cardiac function monitoring system based on a conformal and flexible strain sensor array and deep learning neural networks. The sensor has a variety of advantages, including high sensitivity, high linearity, fast response and recovery, and high isotropy. Experiments and simulation synergistically verified that the sensor array can acquire high-precise and feature-rich pulse waves from the wrist without precise positioning. By combining high-quality pulse waves with a well-trained deep learning model, we can monitor blood pressure and cardiac function parameters. As a proof of concept, we further constructed an intelligent wearable system for real-time and long-term monitoring of blood pressure and cardiac function, which may contribute to personalized health management, precise and early diagnosis, and remote treatment.

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Elastic electronics based on micromesh-structured rubbery semiconductor films

Cited by 39 publications

References 44 publications

Soft Bioelectronics for Therapeutics

Soft Bioelectronics for Therapeutics

Mechanically-Guided 3D Assembly for Architected Flexible Electronics

Monitoring blood pressure and cardiac function without positioning via a deep learning–assisted strain sensor array

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