Elastic recovery of filler-binders to safeguard viability of Lactobacillus rhamnosus GG during direct compression

Byl, Eline; Lebeer, Sarah; Kiekens, Filip

doi:10.1016/j.ejpb.2018.12.005

Cited by 10 publications

(12 citation statements)

References 22 publications

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“…Since data were randomly distributed (R 2 of 0.220 for linear regression) in Figure 5b, no correlation was found between the mean yield pressure of the formulation and the survival rate. This is in line with observations that were reported for a strain of Lactobacillus rhamnosus where the bacterial cell survival was not correlated to the mean yield pressure of different filler-binders [13]. observations that were reported for a strain of Lactobacillus rhamnosus where the bacterial cell survival was not correlated to the mean yield pressure of different filler-binders [13].…”

Section: Compression Analysissupporting

confidence: 89%

“…This is in line with observations that were reported for a strain of Lactobacillus rhamnosus where the bacterial cell survival was not correlated to the mean yield pressure of different filler-binders [13]. observations that were reported for a strain of Lactobacillus rhamnosus where the bacterial cell survival was not correlated to the mean yield pressure of different filler-binders [13]. From mean yield pressures, deformation behavior can be interpreted.…”

Section: Compression Analysissupporting

confidence: 88%

“…30% compared to approx. 70% when more elastic MCC was added [13]. However, considering Figure 6b, the global and sole dependency of survival rate on elastic recovery or such a dependency exceeding the influence of the formulation were not found in this study.…”

Section: Elastic Recoverycontrasting

confidence: 69%

“…The fact that large cells are damaged more strongly suggests mechanical stress (shearing) as the significant factor [9]. Besides dependency on cell size, the degree of damage also seems to be dependent on the compaction stress [10,11], compression speed [11], spatial distribution [12] and mechanical as well as physical properties of the used excipients, e.g., deformation characteristics [9,[11][12][13] and particle size [10]. In general, increasing the compaction stress lowers the viability of tableted microorganisms independently of other influencing factors.…”

Section: Introductionmentioning

confidence: 99%

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Along the Process Chain to Probiotic Tablets: Evaluation of Mechanical Impacts on Microbial Viability

et al. 2020

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Today, probiotics are predominantly used in liquid or semi-solid functionalized foods, showing a rapid loss of cell viability. Due to the increasing spread of antibiotic resistance, probiotics are promising in pharmaceutical development because of their antimicrobial effects. This increases the formulation requirements, e.g., the need for an enhanced shelf life that is achieved by drying, mainly by lyophilization. For oral administration, the process chain for production of tablets containing microorganisms is of high interest and, thus, was investigated in this study. Lyophilization as an initial process step showed low cell survival of only 12.8%. However, the addition of cryoprotectants enabled survival rates up to 42.9%. Subsequently, the dried cells were gently milled. This powder was tableted directly or after mixing with excipients microcrystalline cellulose, dicalcium phosphate or lactose. Survival rates during tableting varied between 1.4% and 24.1%, depending on the formulation and the applied compaction stress. More detailed analysis of the tablet properties showed advantages of excipients in respect of cell survival and tablet mechanical strength. Maximum overall survival rate along the complete manufacturing process was >5%, enabling doses of 6 × 10 8 colony forming units per gram ( CFU g total − 1 ), including cryoprotectants and excipients.

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Section: Compression Analysissupporting

confidence: 89%

Section: Compression Analysissupporting

confidence: 88%

Section: Elastic Recoverycontrasting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

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Along the Process Chain to Probiotic Tablets: Evaluation of Mechanical Impacts on Microbial Viability

et al. 2020

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“…The compression pressure used in chewable tablet production can decrease the probiotic cell count dramatically. The extent of the compression cell count loss will depend on the formulation and probiotic strain [35]. Tests should be performed to understand the minimum amount of compression required to produce a tablet with acceptable friability characteristics in an effort to preserve as many live cells as possible.…”

Section: Inclusion Of Probiotics In Dietary Supplementsmentioning

confidence: 99%

The Production and Delivery of Probiotics: A Review of a Practical Approach

et al. 2019

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To successfully deliver probiotic benefits to the consumer, several criteria must be met. Here, we discuss the often-forgotten challenges in manufacturing the strains and incorporating them in consumer products that provide the required dose at the end of shelf life. For manufacturing, an intricate production process is required that ensures both high yield and stability and must also be able to meet requirements such as the absence of specific allergens, which precludes some obvious culture media ingredients. Reproducibility is important to ensure constant high performance and quality. To ensure this, quality control throughout the whole production process, from raw materials to the final product, is essential, as is the documentation of this quality control. Consumer product formulation requires extensive skill and experience. Traditionally, probiotic lactic acid bacteria and bifidobacteria have been incorporated in fermented dairy products, with limited shelf life and refrigerated storage. Currently, probiotics may be incorporated in dietary supplements and other “dry” food matrices which are expected to have up to 24 months of stability at ambient temperature and humidity. With the right choice of production process, product formulation, and strains, high-quality probiotics can be successfully included in a wide variety of delivery formats to suit consumer requirements.

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Importance of pressure plasticity during compression of probiotic tablet formulations

Byl

Bladt

Lebeer

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

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Elastic recovery of filler-binders to safeguard viability of Lactobacillus rhamnosus GG during direct compression

Cited by 10 publications

References 22 publications

Along the Process Chain to Probiotic Tablets: Evaluation of Mechanical Impacts on Microbial Viability

Along the Process Chain to Probiotic Tablets: Evaluation of Mechanical Impacts on Microbial Viability

The Production and Delivery of Probiotics: A Review of a Practical Approach

Importance of pressure plasticity during compression of probiotic tablet formulations

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