2019
DOI: 10.1039/c8lc00849c
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Elastic reversible valves on centrifugal microfluidic platforms

Abstract: We developed and modeled tunable reversible valves on microfluidic discs, and employed them to automate a multiplexed immunoassay with peptide microarrays.

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Cited by 33 publications
(25 citation statements)
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“…Theoretically, (2) can be made arbitrarily large through sufficiently shrinking the final volume (for a static 0 defined by Γ). Note that, in addition to the compressibility, a volume-pressure relationship akin to (2) can also arise in fluidic systems containing flexible solid elements such as elastic lids or membranes [30]. The base pressure 0 may also be modified by heating or cooling [62] according to ∝ (Charles's law).…”
Section: Rotational Flow Controlmentioning
confidence: 99%
“…Theoretically, (2) can be made arbitrarily large through sufficiently shrinking the final volume (for a static 0 defined by Γ). Note that, in addition to the compressibility, a volume-pressure relationship akin to (2) can also arise in fluidic systems containing flexible solid elements such as elastic lids or membranes [30]. The base pressure 0 may also be modified by heating or cooling [62] according to ∝ (Charles's law).…”
Section: Rotational Flow Controlmentioning
confidence: 99%
“…Prominent examples of integrated microfluidic platforms where flow control elements coordinate the spatio-temporal arrangement of a range of LUOs towards sample-to-answer automation are based on rotationally induced centrifugal fields [17][18][19][20][21][22][23][24][25][26], electrokinetics [27], acoustophoresis [28][29][30][31], and digital (droplet) microfluidics on electrowetting-on-dielectric (EWOD) [32][33][34][35][36], surface acoustic waves (SAWs) [37][38][39] and multiphase flows [40][41][42], possibly supported by externally actuated precision pumps and mechanical valves. In this work, we focus on microfluidic technologies for automating typical in vitro procedures in life-science laboratories.…”
Section: Integrated Microfluidic Platformsmentioning
confidence: 99%
“…These LUOs are overwhelmingly processed in a batch-wise, rather than a continuous-flow fashion, by transiently sealing their fluidic exit with a normally-closed valve, thus intermittently stopping the flow while continuing rotation within certain boundaries, e.g., for vigorous agitation of the liquid sample. These centrifugal LUOs and their linked downstream detection techniques have been comprehensive reviewed elsewhere [24][25][26][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67].…”
Section: Introductionmentioning
confidence: 99%