Elastic vesicles as topical/transdermal drug delivery systems

Choi, Myeong Jun; Maibach, Howard I.

doi:10.1111/j.1467-2494.2005.00264.x

Cited by 74 publications

(30 citation statements)

References 54 publications

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“…While lipophilic and polymer particles are commonly used to deliver substances across skin (Choi and Maibach, 2005; Benson, 2009; Rancan et al, 2009), these particle types are typically designed to degrade. Therefore, they may comprise inferior adjuvants compared to hard insoluble nanoparticles that maybe retained longer periods of times in skin.…”

Section: Nanoparticle Based Therapeuticsmentioning

confidence: 99%

Applications of Nanotechnology in Dermatology

DeLouise

2012

Journal of Investigative Dermatology

171

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What are nanoparticles and why are they important in dermatology? These questions are addressed by highlighting recent developments in the nanotechnology field that have increased the potential for intentional and unintended nanoparticle skin exposure. The role of environmental factors in the interaction of nanoparticles with skin and the potential mechanisms by which nanoparticles may influence skin response to environmental factors are discussed. Trends emerging from recent literature suggest that the positive benefit of engineered nanoparticles for use in cosmetics and as tools for understanding skin biology and curing skin disease, out weigh potential toxicity concerns. Discoveries reported in this journal are highlighted. This review begins with a general introduction to the field of nanotechnology and nanomedicine. This is followed by a discussion of the current state of understanding of nanoparticle skin penetration and their use in three different therapeutic applications. Challenges that must be overcome to derive clinical benefit from the application of nanotechnology to skin are discussed last, providing perspective on the significant opportunity that exists for future studies in investigative dermatology.

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Section: Nanoparticle Based Therapeuticsmentioning

confidence: 99%

Applications of Nanotechnology in Dermatology

DeLouise

2012

Journal of Investigative Dermatology

171

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“…T4 endonuclease V [109][110][111]. This concept has been further extended and nowadays, liposomes exhibiting high transdermal flux based on a extreme deformability are described in the literature as Transferosomes TM and ethosomes depending on their chemical composition [112][113][114][115]. The former are vehicles mainly composed of phosphatidylcholine and a bilayer softening compound, e.g.…”

Section: Liposomesmentioning

confidence: 99%

Artificial Sun Protection: Sunscreens and Their Carrier Systems

Villalobos-Hernández¹,

Müller‐Goymann²

2006

CDD

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The formulation of sunscreens products requires information about the properties of the substances responsible for the sun protection, their action mechanisms and the vehicles used for their administration. The improvement of the performance of sunscreen substances by a modification of their chemical, physical and technological properties or by the use of conventional and novel carriers is described in this review. The sun protection achieved by the use of sunscreens incorporated into carriers in terms of the sun protection factor (SPF) and other performance indices is also shown. Current manufacturing methods to incorporate sunscreen substances into vehicles are briefly described. Furthermore, basic information related to the dermatological effects of the UV radiation classified according to the different spectral regions of the UV radiation is presented in this manuscript.

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“…Use of a particular type of liposomes called ‘elastic vesicles’ has been suggested as being of enhanced efficacy with respect to drug delivery to skin 93–96. It has been argued that such highly deformable liposomes could steal into the narrow spaces of the intercellular lipidic medium of the stratum corneum .…”

Section: Skin Penetration Of Organic Particles In Pharmaceutical Applmentioning

confidence: 99%

Nanoparticles through the skin: managing conflicting results of inorganic and organic particles in cosmetics and pharmaceutics

Bolzinger

Briançon

Chevalier

2011

WIREs Nanomed Nanobiotechnol

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Toxicity of nanoparticles is a current scientific issue because of the enhanced reactivity of nanomaterials and their possible easy penetration into the body arising from their small size. Because inorganic particles are present in sunscreen cosmetic products, attention has been focused on cutaneous penetration. But organic particles of various sizes are also used in pharmaceutical applications such as skin care and transdermal drug delivery. It appears that organic and inorganic particles penetrate the skin quite differently. The apparent discrepancy is addressed in this review focusing on skin penetration of inorganic sunscreen particles and organic particles for drug delivery. After a short description of the physicochemical properties of these particles, the skin penetration of both types is reviewed with emphasis on the mechanistic issues and the differences that could account for such conflicting results. It appears that investigations by cosmetic and pharmaceutical communities focused on the main issue, i.e., no toxicity in cosmetics and maximum activity of the drug in pharmaceutics. This leaves several fundamental issues as open questions and this does not allow a rigorous comparison between both types of material. While it is claimed that inorganic nanoparticles can only penetrate the outer layer of the skin, it appears that organic submicron particles and even microparticles reach the dermis in an in vitro cell. Besides particle size, the surface chemistry of the particles and the presence of other excipients in the formulations contribute to skin absorption.

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Elastic vesicles as topical/transdermal drug delivery systems

Cited by 74 publications

References 54 publications

Applications of Nanotechnology in Dermatology

Applications of Nanotechnology in Dermatology

Artificial Sun Protection: Sunscreens and Their Carrier Systems

Nanoparticles through the skin: managing conflicting results of inorganic and organic particles in cosmetics and pharmaceutics

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