Elastin fiber but not collagen fiber is decreased dramatically in the dermis of vitiligo patients

Hirobe, Tomohisa; Enami, Hisao; Nakayama, Ai

doi:10.1111/ijd.14896

Cited by 6 publications

(9 citation statements)

References 5 publications

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“…A “melanoblast” is defined here as an unpigmented cell that possesses no tyrosinase activity. Collagen staining (Aniline blue) and elastin staining (Victoria blue) were also reported previously [ 12 ].…”

Section: Methodsmentioning

confidence: 59%

“…Our preliminary study demonstrated that elastin fibers were decreased in vitiliginous skin, suggesting the possibility that elastin fibers are involved in vitiligo development and repigmentation [ 12 ]. In this study, to confirm our hypothesis, we investigated whether the reduced elastin fibers and melanocyte loss in vitiliginous skin can be restored after phototherapy and/or skin transplantation.…”

Section: Introductionmentioning

confidence: 99%

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Reduced Elastin Fibers and Melanocyte Loss in Vitiliginous Skin Are Restored after Repigmentation by Phototherapy and/or Autologous Minigraft Transplantation

Hirobe¹,

Enami²

2022

IJMS

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Vitiligo is a hypopigmentation disease characterized by melanocyte death in the human epidermis. However, the mechanism of vitiligo development and repigmentation is largely unknown. Dermal fiber components might play an important role in vitiligo development and repigmentation. Indeed, our preliminary study demonstrated that elastin fibers were decreased in vitiliginous skin, suggesting that the elastin fiber is one of the factors involved in vitiligo development and repigmentation. To confirm our hypothesis, we investigated whether elastin fibers can be restored after treatment using phototherapy and/or autologous skin transplantation. Punch biopsies from 14 patients of stable nonsegmental vitiligo vulgaris were collected from nonlesional, lesional, and repigmented skin, and processed to dopa and combined dopa–premelanin reactions. Melanocytes positive to the dopa reaction and melanoblasts/melanocytes positive to the combined dopa–premelanin reaction were surveyed. Moreover, elastin fibers were detected by Victoria blue staining. Numerous melanocytes and melanoblasts were observed in the epidermis of repigmented skin after the treatment. Moreover, in the dermis of repigmented skin, elastin fibers were completely recovered or even upregulated. These results suggest that melanocyte loss in the vitiliginous skin, as well as melanocyte differentiation in repigmented skin, may be at least in part regulated by elastin fibers in the dermis.

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Section: Methodsmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Reduced Elastin Fibers and Melanocyte Loss in Vitiliginous Skin Are Restored after Repigmentation by Phototherapy and/or Autologous Minigraft Transplantation

Hirobe¹,

Enami²

2022

IJMS

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“…The interaction between melanocytes and the surrounding tissue environments is important for regulating the function of mammalian melanocytes. Recently, dermal fibers such as collagen and elastin fibers have been paid particular attention in addition to these factors (19)(20)(21)(22). Collagen fibers are major dermal components, and their precursors, collagen molecules, have triple-helix conformation, produce long thin fibrils or two-dimensional reticular, or connect with other extracellular matrix elements.…”

Section: Contextmentioning

confidence: 99%

Elastin is Related to Functions of Melanocytes in Normal and Abnormal Skin

Hirobe

2023

J Skin Stem Cell

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Context: Functions of melanocytes are supported by many growth factors and cytokines derived from epidermal and dermal cells, especially keratinocytes and fibroblasts. In addition to these skin cells, elastin fibers are thought to be important for regulating melanocyte functions in normal and abnormal skin. However, the role of elastin has not been fully investigated. Recently, the research on the role of elastin in melanocyte functions has greatly increased even in human skin, whereas no full review article on this subject has been presented so far. Thus, the author tried to present a complete review article on this subject in animals and humans. Methods: The author searched the literature on elastin and melanocytes in research databases. Results: Elastin fibers can affect the normal functions of melanoblasts/melanocytes in animals and humans. Moreover, elastin fibers influence melanocyte functions in abnormal skin. In vitiliginous skin, where melanin and melanoblasts/melanocytes are completely lost, elastin fibers are dramatically reduced. However, elastin fibers are completely restored or even increased in the dermis of repigmented skin after phototherapy and/or skin transplantation. Moreover, elastin fibers penetrate the basement membrane of repigmented skin, suggesting a direct contact between dermal elastin fibers and epidermal melanoblasts/melanocytes. Conclusions: Elastin/elastin fibers may control the functions of mammalian melanocytes in normal and abnormal skin.

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“… 43 Additionally, elastin is reduced in lesional dermis, but collagen fibers show no difference when compared to unaffected skin. 46 …”

Section: Morphofunctional Changesmentioning

confidence: 99%

Update on the pathogenesis of vitiligo

Marchioro

Castro

Fava

et al. 2022

Anais Brasileiros de Dermatologia

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Elastin fiber but not collagen fiber is decreased dramatically in the dermis of vitiligo patients

Cited by 6 publications

References 5 publications

Reduced Elastin Fibers and Melanocyte Loss in Vitiliginous Skin Are Restored after Repigmentation by Phototherapy and/or Autologous Minigraft Transplantation

Reduced Elastin Fibers and Melanocyte Loss in Vitiliginous Skin Are Restored after Repigmentation by Phototherapy and/or Autologous Minigraft Transplantation

Elastin is Related to Functions of Melanocytes in Normal and Abnormal Skin

Update on the pathogenesis of vitiligo

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