Elastin peptide receptor-directed monocyte chemotactic polysaccharides derived from seaweed sporophyll and from infectious fungus

New evidence for a critical role of elastin in calcification of native heart valves: immunohistochemical and ultrastructural study with literature review

“…It has been demonstrated extensively that elastinderived peptides generated by degradation of elastic fibres can trigger several cellular reactions, ranging from biosynthesis of connective tissue to a shift in cell phenotype. [51][52][53][54][55] We havedemonstrated that two different bone-marker proteins are synthesized actively in the native stenotic valves, suggesting that a subset of lesional valvular cells might undergo osteogenic differentiation and might contribute actively to the production of osteopontin in proximity to the calcified nodules. Of note, the lesional tissues used in our study exhibited cartilaginous metaplasia with the presence of cartilaginous foci that are amenable to calcification.…”

Structural Features and Immunomodulatory Effects of Water-Extractable Polysaccharides from Macrolepiota procera (Scop.) Singer

“…Unlike β -glucans, immune-related receptors for immunomodulating fucogalactan recognition are still unclear, which, from a biochemical point of view, should be elucidated in the near future. For example, Li et al have revealed that a sulfated fucogalactan from the seaweed Undaria pinnatifida can be recognized by the elastin-peptide receptor on monocytes, assuming the Gal-binding lectin site of the receptor interacts with Gal [ 85 ]. However, there are some structural differences between mushroom and seaweed fucogalactans, which can restrict the possibility to activate the same receptors on the cell surface of target cells.…”

Molecular Targets and Related Biologic Activities of Fucoidan: A Review

“…The potential target of fucoidan for regulating immune function is not limited to the PRRs mentioned in the above sections. Fucoidan binds to elastin peptide receptor of monocytes, recruiting monocytes in vitro and in vivo ( Table 1 ) [ 54 ]. Interestingly, a polysaccharide from pathogenic fungus, Candida albicans , has similar chemoattracting properties to fucoidan, even though the concentration is lower.…”

“…Interestingly, a polysaccharide from pathogenic fungus, Candida albicans , has similar chemoattracting properties to fucoidan, even though the concentration is lower. Thereby Li et al speculated that the chemotactic response of monocytes to the sulfated fucogalactan is part of the innate immune system to fungal infection [ 54 ].…”