Elastofibroma presenting as an oral soft tissue mass

Manchandu, Ritu; Foote, Joseph; Alawi, Faizan

doi:10.1111/j.1600-0714.2007.00592.x

Cited by 10 publications

(16 citation statements)

References 5 publications

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“…One patient had history of homolateral squamous cell carcinoma, a similar setting as with the patient reported by Manchandu et al [3]. In our case there was, however, mild epithelial dysplasia and focal acute inflammation.…”

Section: Discussionmentioning

confidence: 45%

“…Both tumors presented on the left side of the floor of the mouth and were asymptomatic, small white, smooth-surfaced, and well-circumscribed nodules. In one patient there was a history of accidental injury of the area, approximately 52 years before diagnosis of the elastofibroma [2], while in the other the tumor developed in site of a squamous cell carcinoma 2 years after resection and radiation therapy [3].…”

Section: Discussionmentioning

confidence: 99%

“…This may be due to either their true rarity or to being simply overlooked, in particular when they do not comprise the main component of a lesion. A review of the pertinent literature has disclosed only two cases of oral elastofibroma [2,3], and a single case of penicillamine-induced elastosis of the lip mucosa in a patient with Wilson's disease [4].…”

Section: Introductionmentioning

confidence: 99%

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Elastofibromatous Changes and Hyperelastosis of the Oral Mucosa

Tosios

Economou

Vasilopoulos

et al. 2009

Head and Neck Pathol

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Three cases of abnormalities of elastic fibers, two of them on the floor of the mouth and one on the lingual alveolar mucosa, close to the floor of the mouth, in a patient with history of homolateral squamous cell carcinoma of the floor of the mouth, are presented. Comparison with elastofibromatous changes and elastofibromas are made and their possible pathogenesis is discussed. It is suggested that increased awareness may facilitate recognition of such lesions as they can be easily overlooked, especially when they do not present as discrete tumors or they are associated with other ''more significant'' pathologic processes.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Elastofibromatous Changes and Hyperelastosis of the Oral Mucosa

Tosios

Economou

Vasilopoulos

et al. 2009

Head and Neck Pathol

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“…It was first described by Jarvi and Saxen [1], occurring in the subscapular region (elastofibroma dorsi) as a painless non-fixed mass [1][2][3][4]. Mucosal lesions are rare, but have occasionally been reported [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Oral Elastofibromatous Lesions: A Review and Case Series

Darling

Kutalowski

MacPherson

et al. 2011

Head and Neck Pathol

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Elastofibromas of the oral cavity are rare, with only 5 cases reported. In this paper, we present a series of five new cases of oral elastofibromatous lesions, occurring in 4 males and 1 female, with ages ranging from 33 to 76 years. The clinical differential diagnosis includes fibroepithelial polyp or fibroma, among other connective tissue tumours. Elastofibromas probably develop as reactive lesions, for which surgical treatment is definitive.

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“…Furthermore, several cases presenting elastofibromatous changes in the oral mucosa have been reported in recent years (9)(10)(11)(12)(13)(14). As mentioned above, elastic fibers are also distributed around the vascular wall in the oral mucosal tissues and are speculated to be involved in the pathogenesis of OFH.…”

Section: Introductionmentioning

confidence: 99%

Histopathological and Immunohistochemical Studies of the Distribution of Elastic Fibers in Oral Fibrous Hyperplasia

Oshima

2014

Int J Oral-Med Sci

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Oral fibrous hyperplasias (OFH) are thought to result from hyperplasia of collagen fibers.However, details regarding the presence of elastic fibers and reticular fibers other than collagen fibers in OFH are unclear.Therefore, this study focused on elastic fibers in the connective tissue with regard to OFH, and assessed the histopathological, histochemical, and immunohistochemical distribution of the elastic fibers.All cases of OFH (120 cases) were performed Elastica van Gieson (EvG) staining, and the distribution of elastic fibers was assessed using image analysis (binarization). Cases were classified into 2 groups; one group with elastic fibers (EF+ group) and one group without elastic fibers (EF−group). Histopathologically, elastic fibers were observed with mingled hyperplastic collagen fiber bundles and extended in the lesion. The distribution quantity of elastic fibers was fibroma of labial mucosa and buccal mucosa, and there were fewer elastic fibers in fibrous epulis and fibromatous epulis. Immunohistochemically, spindle cells in all cases of OFH were diffusely positive for Vimentin and negative for Actin, and CD34-positive spindle cells were interspersed into the connective tissue in EF+ group. In conclusion, elastic fibers were observed in 57.5% of OFH cases. The distribution of these fibers was site-specific, and differed from the collagen fibers that constituted OFH. CD34 positivity was observed in the spindle cells constituting OFH accompanied by elastic fibers, and undifferentiated mesenchymal cells around myogenic blood vessels near the lesion were related to the formation of a part of elastic fibers that constituted OFH.

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Elastofibroma presenting as an oral soft tissue mass

Cited by 10 publications

References 5 publications

Elastofibromatous Changes and Hyperelastosis of the Oral Mucosa

Elastofibromatous Changes and Hyperelastosis of the Oral Mucosa

Oral Elastofibromatous Lesions: A Review and Case Series

Histopathological and Immunohistochemical Studies of the Distribution of Elastic Fibers in Oral Fibrous Hyperplasia

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