Elastolysis and Giant Cell Reaction against Disintegrated Elastic Fibres

Shionoya, Shigehiko; Tsunekawa, Susumu; Kamiya, Kisaku

doi:10.1038/207311a0

Cited by 15 publications

(5 citation statements)

References 4 publications

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“…Granulomatous tissue reaction can also be induced by degenerated elastic fibers in vivo. Shinoya et al (7) have indicated that, when elastase is introduced in rabbits, it shows elastolytic properties, while the fragmented fibers stimulate a granulomatous tissue reaction with concomitant multinucleated giant cell formation. : This suggests that altered elastic fibers may act in a manner similar to that of heterologous elastin, provoking a granulomatous tissue reaction.…”

Section: Discussionmentioning

confidence: 99%

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Granulomatous Tissue Reaction and Calcification of Heterologous Elastin Implanted in Hairless Mouse Skin: Light and Electron Microscopic Studies Compared with Reaction of Heterologous Collagen

Tsuji

Sawabe

1993

The Journal of Dermatology

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Heterologous elastin particles were injected into the deep dermis or below the panniculus carnosus of hairless mice. A granulomatous tissue reaction with concomitant giant cell formation occurred around the implanted elastin in the early stages and, subsequently, calcium deposition with disappearance of the histiocytes and giant cells occurred in the later stages. Ultrastructural study revealed that some elastin particles were engulfed by the giant cells; others underwent calcification but remained intact. The heterologous collagen used as a control also induced a granulomatous tissue reaction, but did not undergo calcification and gradually disappeared. These results suggest that the heterologous elastin and collagen particles exhibit different susceptibilities to digestion. However, it is not clear why the heterologous elastin underwent calcification.

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Section: Discussionmentioning

confidence: 99%

“…As far as we know, there are only two experimental reports concerning this subject. Shinoya et al (7) studied the tissue reaction to elastic fibers after introducing elastase in rabbits. Papajiannis et al (8) studied the fate of heterologous elastin implanted intraperitoneally and in the foot pads of rats.…”

Section: Introductionmentioning

confidence: 99%

Granulomatous Tissue Reaction and Calcification of Heterologous Elastin Implanted in Hairless Mouse Skin: Light and Electron Microscopic Studies Compared with Reaction of Heterologous Collagen

Tsuji

Sawabe

1993

The Journal of Dermatology

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“…7). Two conditions are necessary for the occurrence of the elasticophagic giant cell: (a) a specific destruction of the elastic fibers to provoke the giant cell for example, hard and slightly soluble fragments of the internal elastic lamina; and (b) a mesenchymal activation [3]. In the media, a myogenic giant cell may rarely be noticed in the granulation tissue (Fig.…”

Section: Late Stagementioning

confidence: 99%

What is Buerger's disease?

Shionoya

1983

World j. surg.

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In analyzing our observations of 115 patients with Buerger's disease during a recent 4-year period, the following results were obtained. First, Buerger's disease is primarily a disease of the small-and medium-sized vessels of the extremity. The disease commences peripherally and reaches the infrapopliteal or forearm arteries within a short time after the onset of symptoms. The majority of the patients have 3-or 4-limb involvement. Although the first ischemic manifestation is variable, a trophic lesion is the chief symptom at the first examination.Second, in contrast to an incessant deterioration of the peripheral circulation, proximal extension is less frequent. The skip lesion plays an important role in proximal progression of the obstructive lesion in the main artery.Third, although direct arterial surgery is infrequently feasible because of the distal occlusive process, successful arterial revascularization is most effective for healing of ulceration. All efforts should be concentrated on limb salvage.Furthermore, microabscess consisting of giant cells, epithelioid cells, and ieukocytes lends the most characteristic appearance to the thrombotic lesion at the early stage. General architecture of the vessel wall is well preserved at the healed stage.Finally, the etiology remains unknown. In this regard, however, we have a very strong clue in the astoundingly close relationship between the use of tobacco and the occurrence of the disease. If the patient absolutely abandons smoking, the natural history of the disease is uneventful.

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“…The tissue injury associated with GCA appears to be mediated by products of macrophage activation, including ROS and matrix metalloproteinases [70,163] , which can damage the internal elastic lamina and contribute to giant cell formation [164] . In addition, peptides generated during elastin hydrolysis can serve as autoimmune targets for the T cells [165] , and it has been reported that adventitial CD4 + T cells can undergo clonal expansion in the adventitia and that adventitial dendritic cells play a key role in this process by serving as antigen-presenting cells [160,162] .…”

Section: Giant Cell Arteritismentioning

confidence: 99%

Role of NADPH Oxidase in Formation and Function of Multinucleated Giant Cells

Quinn

Schepetkin²

2009

J Innate Immun

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Macrophages play essential roles in a wide variety of physiological and pathological processes. One of the unique features of these phagocytic leukocytes is their ability to fuse, forming multinucleated giant cells. Multinucleated giant cells are important mediators of tissue remodeling and repair and are also responsible for removal or sequestration of foreign material, intracellular bacteria and non-phagocytosable pathogens, such as parasites and fungi. Depending on the tissue where fusion occurs and the inflammatory insult, multinucleated giant cells assume distinctly different phenotypes. Nevertheless, the ultimate outcome is the formation of large cells that can resorb bone tissue (osteoclasts) or foreign material and pathogens (giant cells) extracellularly. While progress has been made in recent years, the mechanisms and factors involved in macrophage fusion are still not fully understood. In addition to cytokines and a number of adhesion proteins and receptors, it is becoming increasingly clear that NADPH oxidase-generated reactive oxygen species (ROS) also play an important role in macrophage fusion. In this review, we provide an overview of macrophage multinucleation, with a specific focus on the role of NADPH oxidases and ROS in macrophage fusion and in the function of multinucleated giant cells. In addition, we provide an updated overview of the role of these cells in inflammation and various autoimmune diseases.

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Elastolysis and Giant Cell Reaction against Disintegrated Elastic Fibres

Cited by 15 publications

References 4 publications

Granulomatous Tissue Reaction and Calcification of Heterologous Elastin Implanted in Hairless Mouse Skin: Light and Electron Microscopic Studies Compared with Reaction of Heterologous Collagen

Granulomatous Tissue Reaction and Calcification of Heterologous Elastin Implanted in Hairless Mouse Skin: Light and Electron Microscopic Studies Compared with Reaction of Heterologous Collagen

What is Buerger's disease?

Role of NADPH Oxidase in Formation and Function of Multinucleated Giant Cells

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