Elastomeric Closures for Pharmaceutical Packaging

Hopkins, George

doi:10.1002/jps.2600540131

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1966

2024

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Cited by 12 publications

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“…Elastomeric pharmaceutical closures should not react with, absorb, or release harmful impurities into the drug product. The possibility of rubber closures to leach chemicals into drug compositions was noticed at early as in 1964 [1]. Vulcanization accelerators and antioxidants were found in the drug composition [2].…”

Section: Introductionmentioning

confidence: 99%

The Potential Use of Natural Rubber in Pharmaceutical Closures

Bích¹,

Trang²,

Luan³

et al. 2016

Progress in Rubber, Plastics and Recycling Technology

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Current manufacturing techniques could produce natural rubber closures that meet all criteria standardized by pharmacopeias except the ultraviolet absorbance limit in the range of 220–360 nm for the closures’ leachate. The type and the dosage of the rubber compounds’ ingredients affected the ultraviolet absorbance of the leachate, while rinsing the closures in water with ultrasonic waves and ozone did not. Intensive washing of the rubber coagulum and deproteinization of the rubber latex using bromelain reduced ultraviolet absorbance of the leachate significantly. Further purification of natural rubber latex is necessary to enable the use of natural rubber in pharmaceutical closures.

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Section: Introductionmentioning

confidence: 99%