Elatoside C protects the heart from ischaemia/reperfusion injury through the modulation of oxidative stress and intracellular Ca2+ homeostasis

Wang, Min; Sun, Guibo; Zhang, Jingyi; Luo, Yun; Yu, Yingli; Xu, Xudong; Meng, Xiangbao; Zhang, Miao-di; Lin, Wenbin; Sun, Xiaobo

doi:10.1016/j.ijcard.2015.03.140

Cited by 40 publications

(34 citation statements)

References 32 publications

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“…Numerous reports indicate that myocardial ischaemia/reperfusion would cause a sharp decline in cardiac function, leading to a marked decrease in LVSP, heart rate and ventricular contractility . The present study has provided evidence that Araloside C pre‐treatment concentration‐dependently promotes the recovery of I/R‐induced myocardial dysfunction in rats.…”

Section: Discussionsupporting

confidence: 65%

“…of reperfusion, LVSP was 86.11 + 8.82% of baseline levels in the Araloside C + I/R treatment group, while Elatoside C, another major triterpenoid saponin isolated from A. elata , was 75.66 + 10.2% of baseline levels at the 30 min. of reperfusion in our previous report . It seems that the effect of Araloside C is a little stronger than that of Elatoside C on cardiac function of the I/R hearts.…”

Section: Discussionmentioning

confidence: 52%

“…As described in our previous study , male Sprague–Dawley rats were anesthetized with sodium pentobarbital (45 mg/kg i.p.) and heparinized.…”

Section: Methodsmentioning

confidence: 99%

“…A cellular model of simulated I/R was used as previously described . Briefly, control recordings were made for 15 min.…”

Section: Methodsmentioning

confidence: 99%

“…Various oleanane‐type triterpene saponins were isolated and identified from AS, which might contribute to the cardioprotective effects of AS . For example, Elatoside C was recently reported to significantly reduce cardiac injury during I/R and alleviate hypoxia/reoxygenation (H/R)‐induced cardiomyocyte apoptosis . Thus, it is interesting to explore the active compounds from AS with cardioprotective potentials.…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of Araloside C against myocardial ischaemia/reperfusion injury: potential involvement of heat shock protein 90

Wang

Tian

et al. 2017

J Cellular Molecular Medi

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The present study was designed to investigate whether Araloside C, one of the major triterpenoid compounds isolated from Aralia elata known to be cardioprotective, can improve heart function following ischaemia/reperfusion (I/R) injury and elucidate its underlying mechanisms. We observed that Araloside C concentration‐dependently improved cardiac function and depressed oxidative stress induced by I/R. Similar protection was confirmed in isolated cardiomyocytes characterized by maintaining Ca2+ transients and cell shortening against I/R. Moreover, the potential targets of Araloside C were predicted using the DDI‐CPI server and Discovery Studio software. Molecular docking analysis revealed that Araloside C could be stably docked into the ATP/ADP‐binding domain of the heat shock protein 90 (Hsp90) protein via the formation of hydrogen bonds. The binding affinity of Hsp90 to Araloside C was detected using nanopore optical interferometry and yielded KD values of 29 μM. Araloside C also up‐regulated the expression levels of Hsp90 and improved cell viability in hypoxia/reoxygenation‐treated H9c2 cardiomyocytes, whereas the addition of 17‐AAG, a pharmacologic inhibitor of Hsp90, attenuated Araloside C‐induced cardioprotective effect. These findings reveal that Araloside C can efficiently attenuate myocardial I/R injury by reducing I/R‐induced oxidative stress and [Ca2+]i overload, which was possibly related to its binding to the Hsp90 protein.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 52%

“…As described in our previous study , male Sprague–Dawley rats were anesthetized with sodium pentobarbital (45 mg/kg i.p.) and heparinized.…”

Section: Methodsmentioning

confidence: 99%

“…A cellular model of simulated I/R was used as previously described . Briefly, control recordings were made for 15 min.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protective effects of Araloside C against myocardial ischaemia/reperfusion injury: potential involvement of heat shock protein 90

Wang

Tian

et al. 2017

J Cellular Molecular Medi

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Saponins as therapeutic candidates for atherosclerosis

Lv,

Wang,

Zeng

et al. 2024

Phytotherapy Research

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Drug development for atherosclerosis, the underlying pathological state of ischemic cardiovascular diseases, has posed a longstanding challenge. Saponins, classified as steroid or triterpenoid glycosides, have shown promising therapeutic potential in the treatment of atherosclerosis. Through an exhaustive examination of scientific literature spanning from May 2013 to May 2023, we identified 82 references evaluating 37 types of saponins in terms of their prospective impacts on atherosclerosis. These studies suggest that saponins have the potential to ameliorate atherosclerosis by regulating lipid metabolism, inhibiting inflammation, suppressing apoptosis, reducing oxidative stress, and modulating smooth muscle cell proliferation and migration, as well as regulating gut microbiota, autophagy, endothelial senescence, and angiogenesis. Notably, ginsenosides exhibit significant potential and manifest essential pharmacological attributes, including lipid‐lowering, anti‐inflammatory, anti‐apoptotic, and anti‐oxidative stress effects. This review provides a comprehensive examination of the pharmacological attributes of saponins in atherosclerosis, with particular emphasis on their role in the regulation of lipid metabolism regulation and anti‐inflammatory effects. Thus, saponins may warrant further investigation as a potential therapy for atherosclerosis. However, due to various reasons such as low oral bioavailability, the clinical application of saponins in the treatment of atherosclerosis still needs further exploration.

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Endoplasmic Reticulum Stress: An Opportunity for Neuroprotective Strategies After Stroke

Louessard

Lemarchand

Ali

et al. 2017

Springer Series in Translational Stroke Research

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Elatoside C protects the heart from ischaemia/reperfusion injury through the modulation of oxidative stress and intracellular Ca2+ homeostasis

Cited by 40 publications

References 32 publications

Protective effects of Araloside C against myocardial ischaemia/reperfusion injury: potential involvement of heat shock protein 90

Protective effects of Araloside C against myocardial ischaemia/reperfusion injury: potential involvement of heat shock protein 90

Saponins as therapeutic candidates for atherosclerosis

Endoplasmic Reticulum Stress: An Opportunity for Neuroprotective Strategies After Stroke

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