Elderly depression in India: An emerging public health challenge

Pilania, Manju; Bairwa, Mohan; Kumar, Neelam; Khanna, Pardeep; Kurana, Hitesh

doi:10.4066/amj.2013.1583

Cited by 58 publications

(45 citation statements)

References 10 publications

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“…Epidemiological studies indicate that nearly 6% of people aged 18 years and older have had a period of depression during the previous year (1). Unfortunately, the use of FLX, a well-known and widely prescribed antidepressant drug, is accompanied by undesirable side effects, including reproductive dysfunction (5-7).…”

Section: Discussionmentioning

confidence: 99%

“…Depression affects approximately 350 million people worldwide, and fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI), is the most commonly used antidepressant (1). Unfortunately, its application is accompanied by undesirable side effects, such as pulmonary, cardiovascular, hepatic, endocrine, and reproductive disorders (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Black Grape Seed Extract Modulates Fluoxetine-Induced Oxidative Stress and Cytotoxicity in the Mouse Testis

Hajizadeh

Mehranjani

Najafi

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widely used in the treatment of neurological disorders. However, its application carries the risk of adverse reactions, including reproductive toxicities. Grape seed is highly regarded for its pharmacological activities, specifically its antioxidant properties. Objectives: This study was designed to evaluate whether hydroalcoholic grape seed extract (GSE) could ameliorate FLX-evoked oxidative injuries in the mouse testis. Materials and Methods: Thirty-two male mice were categorized into four groups of eight mice each. Two groups received FLX at a dose of 20 mg/kg per day over a period of six weeks by oral gavage. One of these groups received GSE at a dose of 100 mg/kg per day orally along with the FLX. An untreated control group and a GSE-only treated group were also included. Serum and testicular samples were collected 24 hours after the last treatment. Results: Biochemical analyses demonstrated that FLX caused significant decreases in testicular antioxidant capacity and serum testosterone concentrations, as well as lipid peroxidation elevations in testicular tissue. Morphometric and histopathological studies supported the biochemical findings. Concomitant administration of GSE with FLX markedly reduced testicular damage and significantly restored all of the mentioned markers to normal values. Conclusions:The findings suggested that oxidative stress-mediated testicular damage, arising as a result of FLX administration in mice, could be reversed by GSE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Black Grape Seed Extract Modulates Fluoxetine-Induced Oxidative Stress and Cytotoxicity in the Mouse Testis

Hajizadeh

Mehranjani

Najafi

et al. 2016

Jundishapur J Nat Pharm Prod

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“…In 1990, the World Health Organization (WHO) described depression as a major cause of disability globally. Mental and behavioral disorders are estimated to account for 12% of the burden of disease[ 2 ] worldwide which affect approximately 450 million[ 2 ] people. By the year 2020, depression will be the single most leading cause[ 3 ] of disability-adjusted life years in the developing countries.…”

Section: Introductionmentioning

confidence: 99%

Magnitude of depression and its correlates among elderly population in a rural area of Maharashtra: A cross-sectional study

Goswami

Deshmukh

Pawar

et al. 2017

J Family Med Prim Care

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Background:Depression is the most common psychiatric disorder among elderly population in India, yet, it is commonly misdiagnosed and undertreated. The exact burden of depression among the elderly population in rural India was not known.Objectives:To study the magnitude of depression among the elderly masses in rural Maharashtra and to find its correlates.Material and Methods:This is a cross sectional study, carried out among the elderly (≥60 years) population of both sexes residing in the field practice area of the department of community medicine. Geriatric depression scale was used for screening depression among the study population. Data collection was completed within 2 months using convenience sampling. Ethical approval was taken before beginning the study. Magnitude was expressed in percentage along with its 95% confidence interval (CI). Univariate and multivariate logistic regression was carried out to study associated correlates. Odds ratio and 95% CI was used to express association.Results:The magnitude of depression among the elderly population was found to be 41.7% (95% CI 36.1–47.4). We got the significant positive association of female sex, living without spouse, lacking in decision making capability, a victim of abuse or neglect, or suffering from chronic illnesses with depression among elderly population in univariate analysis that did not hold good in the multivariate logistic regression. Our study showed the prevalence of mild depression among elderly to be 26.72% and that of severe depression to be 15.17%.Conclusion:To deal with this huge social problem of depression among the elderly population, more enthusiastic steps should be undertaken.

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“…This problem is not new; in 1990, the World Health Organization (WHO) described depression as a major, worldwide cause of disability (Pilania, Bairwa, Kumar, Khanna, & Khurana, 2013). Lifetime prevalence rates of depression range from 8% to 12% in most countries (Andrade, 2003).…”

Section: Introductionmentioning

confidence: 99%

Depression and Hopelessness in Institutionalized Elderly: A Societal Concern

Sarin¹,

Punyaapriya²,

Sethi³

et al. 2016

OJD

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Even though occurrence of depression in older adults is considered a major public health problem, very few Indian studies have made an attempt to study the mental health of elderly residing in institutionalized settings such as nursing homes and old age homes. The purpose of this study is to examine the presence and severity of depression and extent of negative attitudes about the future in institutionalized elderly in India. Data were collected by administering the Beck Depression Inventory (BDI) and Beck Hopelessness Scale (BHS) on residents of different old age homes across Delhi NCR (N = 21). Results revealed presence of mild depression and mild hopelessness in the institutionalized elderly. Further, a positive strong correlation was found between depression and hopelessness (Г = 0.83). Social and emotional losses associated with institutionalization are likely to lead to depressive responses in the elderly. The findings of the study draw attention to the neglected and apathetic conditions of institutionalized elderly, an imperative concern for the Indian society.

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Elderly depression in India: An emerging public health challenge

Cited by 58 publications

References 10 publications

Black Grape Seed Extract Modulates Fluoxetine-Induced Oxidative Stress and Cytotoxicity in the Mouse Testis

Black Grape Seed Extract Modulates Fluoxetine-Induced Oxidative Stress and Cytotoxicity in the Mouse Testis

Magnitude of depression and its correlates among elderly population in a rural area of Maharashtra: A cross-sectional study

Depression and Hopelessness in Institutionalized Elderly: A Societal Concern

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