Elderly with COPD: comoborbitidies and systemic consequences

Mollica, Mariano; Aronne, Luigi; Paoli, Giorgio; Flora, Martina; Mazzeo, Grazia; Tartaglione, Stefania; Polito, Rita; Tranfa, C. M. E.; Ceparano, Maria; Komici, Klara; Mazzarella, Gennaro; Iadevaia, Carlo

doi:10.36150/2499-6564-434

Cited by 8 publications

(6 citation statements)

References 131 publications

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“…Several studies have shown an inverse correlation between the patient's health status and the existence of comorbidities, especially when three or more are associated, regardless of lung function [23][24][25]. Additionally, the risk of exacerbation and hospitalization, mortality, and the economic impact of the disease on healthcare systems are related to the number of comorbidities [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

The Clinical Profile of Patients with COPD Is Conditioned by Age

Morena,

Izquierdo,

Rodríguez

et al. 2023

JCM

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In recent years, many studies have analyzed the importance of integrating time, or aging, into the equation that relates genetics and the environment to the development and origin of COPD. Under conditions of daily clinical practice, our study attempts to identify the differences in the clinical profile of patients with COPD according to age and the impact on the global burden of the disease. This study is non-interventional and observational, using artificial intelligence and data captured from electronic medical records. The study population included patients who were diagnosed with COPD between 2011 and 2021. A total of 73,901 patients had a diagnosis of COPD. The mean age was 73 years (95% CI: 72.9–73.1), and 56,763 were men (76.8%). We observed a specific prevalence of obesity, heart failure, depression, and hiatal hernia in women (p < 0.001), and ischemic heart disease and obstructive sleep apnea (OSA) in men (p < 0.001). In the analysis by age ranges, a progressive increase in cardiovascular risk factors was observed with age. In conclusion, in a real-life setting, COPD is a disease that primarily affects older subjects and frequently presents with comorbidities that are decisive in the evolutionary course of the disease.

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Section: Discussionmentioning

confidence: 99%

The Clinical Profile of Patients with COPD Is Conditioned by Age

Morena,

Izquierdo,

Rodríguez

et al. 2023

JCM

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“…Age is always listed as a risk factor for COPD; elderly patients are often accompanied by other typical comorbidities that negatively impact prognosis and health status, and the number of comorbidities is associated with the risk of COPD exacerbation [11,37]. However, although COPD is common in older people, whether there is difference between elderly patients and middle-aged patients in terms of eosinophilic phenotyperelated COPD outcomes remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic phenotype was associated with better clinical remission in elderly but not middle-aged patients with acute exacerbations of COPD

Zeng

Wang

et al. 2020

Preprint

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Background: There is limited evidence of the relationship between peripheral blood eosinophilia and clinical remission of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) at different ages, especially in elderly patients, which was the objective of the present study. Methods: This retrospective study stratified patients by age (>65 or [?]65 years) and analyzed the relationship between blood eosinophilia ([?]2% or <2%) and AECOPD clinical remission at observing time points of 7, 10, 14, 21, and 28 days. Results: Of 703 AECOPD cases analyzed, 616 were elderly (>65 years), 272 of whom had eosinophilic exacerbations. There were statistically significant differences in leukocyte count, high-sensitivity C-reactive protein levels (hs-CRP), and overall and daily hospital costs between eosinophilic and non-eosinophilic AECOPD patients (p<0.05, respectively). In the overall analysis, eosinophilic exacerbation was significantly associated with a higher remission rate at 7 (hazard ratio [

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“…These include sarcopenia, depression, accelerated cognitive impairment, underweight, osteoporosis, and cardiovascular disease [32,33]. These myriad comorbidities usually lead to decreased functional status, decreased quality of life, and higher mortality when compared with age-matched controls [33]. For this review, we will concentrate on sarcopenia and cognitive impairment.…”

Section: Ageing and Chronic Obstructive Pulmonary Disease: Systemic I...mentioning

confidence: 99%

“…COPD, a disease defined by its impact upon pulmonary function, is nevertheless a systemic disease with multiple extra-pulmonary comorbidities [32], many of which are also products of the ageing process. These include sarcopenia, depression, accelerated cognitive impairment, underweight, osteoporosis, and cardiovascular disease [32,33]. These myriad comorbidities usually lead to decreased functional status, decreased quality of life, and higher mortality when compared with age-matched controls [33].…”

Section: Ageing and Chronic Obstructive Pulmonary Disease: Systemic I...mentioning

confidence: 99%

Ageing and chronic obstructive pulmonary disease: interrelationships

Kakkera

Atchley

Kodali

et al. 2023

Current Opinion in Pulmonary Medicine

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Purpose of reviewAs life expectancy increases, the ageing population accrues an increasing burden of chronic conditions and functional compromise. Some conditions that lead to compromise are deemed part of natural ageing, whereas others are considered to represent disease processes. Ageing (a natural process) and chronic obstructive pulmonary disease (a disease) share many common features, both pulmonary and systemic. At times, the pathways of injury are the same, and at times they are concurrent. In some cases, age and disease are separated not by the presence but by the severity of a finding or condition. This brief review aims to compare some of the similarities between ageing and COPD and to compare/contrast mechanisms for each. Recent findingsAt the cellular level, the natural process of ageing includes multiple systemic and molecular mechanisms. COPD, though defined by progressive pulmonary compromise, can also be a systemic disease/process. It has become evident that specific senescence pathways like p-16 and the sirtuin family of proteins are implicated both in ageing and in COPD. Also common to both ageing and COPD are increased inflammatory markers, leucocyte response abnormalities, and DNA-level abnormalities.

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Elderly with COPD: comoborbitidies and systemic consequences

Cited by 8 publications

References 131 publications

The Clinical Profile of Patients with COPD Is Conditioned by Age

The Clinical Profile of Patients with COPD Is Conditioned by Age

Eosinophilic phenotype was associated with better clinical remission in elderly but not middle-aged patients with acute exacerbations of COPD

Ageing and chronic obstructive pulmonary disease: interrelationships

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