Elective Cardiac Arrest in Open-Heart Surgery: Report of Three Cases

Db, Effler; Lk, Groves; Fm, Sones; Wj, Kolff

doi:10.3949/ccjm.23.2.105

Cited by 60 publications

(20 citation statements)

References 3 publications

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“…In 1953, Wesolowski and colleagues 35 demonstrated that myocardial anoxia, following interruption of the coronary circulation, resulted in myocardial arrest. Similarly, other investigators 36,37 noted that the infusion of potassium salts into the aortic root would provide an electromechanical arrest of the heart. Finally, investigators determined that myocardial hypothermia, induced by perfusion with cold blood or by surface irrigation with cold saline, would cause cardiac arrest.…”

Section: Induced Myocardial Arrestmentioning

confidence: 79%

Cardiopulmonary Bypass: The Historical Foundation, the Future Promise

Galletti¹,

Mora²

1995

Cardiopulmonary Bypass

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Cardiopulmonary bypass (CPB) is used so routinely in hospitals around the world that most of the participantssurgeons, anesthesiologists, perfusionists, operating room nurses and, above all, patients -forget that this landmark in clinical technology is not even 40 years old. In fact, many of the pioneers are still active in the field. Yet, so much has been done to transform a once-hazardous procedure into standard medical practice-through basic science, quality control, and good manufacturing-that one hardly remembers the days (not so long ago) when "pump-oxygenators," as they were graphically called, were assembled just outside the operating room by tinkerers with a dream. The purpose of this chapter is to recall the inventiveness displayed by a small coterie of gifted investigators to whom we owe the mechanical and physiologic foundations of open-heart surgery, and to reflect on the new demands that continuing clinical advances will undoubtedly make on this technology.

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Section: Induced Myocardial Arrestmentioning

confidence: 79%

Cardiopulmonary Bypass: The Historical Foundation, the Future Promise

Galletti¹,

Mora²

1995

Cardiopulmonary Bypass

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“…The most frequent and consistently 18 Jui-Y 1, 1961 observed changes are thrombocytopenia, fibrinogenopenia, and increased fibrinolysis (Osborn et al, 1955;Kay et al, 1956 ;Effler et al, 1956 ;Levowitz et ai., 1956;Cooley et al, 1957;DeWall et al, 1957, 1959von Kaulla andSwan, 1958, Smith et al, 1959 ;Gravel et al, 1959 ;Rothnie and Kinmonth, 1960a). Activation of coagulation with consumption of coagulation factors has been postulated by Brown and Smith (1958), and a decrease of factor V and A.H.G.…”

Section: Discussionmentioning

confidence: 99%

Changes in Blood After Using an Extracorporeal Circulation

Bloom¹

1961

BMJ

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“…Using the technique of Melrose, Kol££ et al (1956) reported 12 ventricular fibrillation in only one of ten dogs with cardiac arrest up to twenty-three minutes, and Effler et al (1956) successfully treated two of three cases of congenital heart disease with the heart resuming normal sinus rhythm in all three cases. However, following thirtyseven open-heart operations, Kolff et al (1957) reported that with potassium citrate, cardiac arrest as long as forty minutes had been attained.…”

Section: Review Of the Literaturementioning

confidence: 99%

Comparative cardio-inhibitory effects of certain cyclohexanol and cyclohexylamine derivatives

Kosegarten

DeFeo

DeFanti

1967

Journal of Pharmaceutical Sciences

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Derivatives of cyclohexanol and cyclohexylamine were pharmacologically screened for cardioplegic effects on intact anesthetized rats, and isolated guinea pig hearts. Evaluation of potency was based on the ability to depress rat carotid blood pressure, and to produce cardiac arrest in the isolated guinea pig heart.As a group, the non-ethynyl cyclohexanol derivatives were more potent in producing a hypotensive response, than were the derivatives of cyclohexylamine. trans-2-£-Tolyl-cis-l, 4-cyclohexanediol and trans-2-£-tolyl-trans-l, 5-cyclohexanediol were equally effective and the most active. trans-2-(E.-Chlorophenyl)-N, N-dimethylcyclohexyl~ amine was the least active, and the only compound to produce a pressor response.Conversely, the cyclohexylamines were more potent cardioplegic agents. The cis and trans isomers of 2-(E.-chlorophenyl)-N, N-dimethyl cyclohexylamine were equally the most active with trans-2-£-tolylcis-l, 4-cyclohexanediol the least active. The minimum effective cardioplegic dose of l-ethynyl-trans-2-£-tolylcyclohexanol was also the cardiotoxic dose as the heart failed to recover from arrest.Mechanism studies on spontaneously beating isolated rat atria indicate an antagonistic effect between calcium and the negative inotropic action of these compounds.

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Elective Cardiac Arrest in Open-Heart Surgery: Report of Three Cases

Cited by 60 publications

References 3 publications

Cardiopulmonary Bypass: The Historical Foundation, the Future Promise

Cardiopulmonary Bypass: The Historical Foundation, the Future Promise

Changes in Blood After Using an Extracorporeal Circulation

Comparative cardio-inhibitory effects of certain cyclohexanol and cyclohexylamine derivatives

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