Elective Pulmonary Lobectomy: Factors Associated with Morbidity and Operative Mortality

Keagy, Blair A.; Lores, M. E.; Starek, Peter J.K.; Murray, Gordon F.; Lucas, Carol L.; Wilcox, Benson R.

doi:10.1016/s0003-4975(10)60065-3

Cited by 126 publications

(54 citation statements)

References 14 publications

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“…Chest drain durations average around 4-5 days, and patients are generally discharged around 4-7 days after surgery. For an ultra-major operation that a mere 30 years ago had a mortality rate approaching 10% and a complication rate of almost 60% (Wilkins et al, 1978;Keagy et al, 1985), these modern figures achieved with VATS are commendable.…”

Section: Wwwintechopencommentioning

confidence: 99%

The Evolution of VATS Lobectomy

Sihoe¹

2012

Topics in Thoracic Surgery

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Section: Wwwintechopencommentioning

confidence: 99%

The Evolution of VATS Lobectomy

Sihoe¹

2012

Topics in Thoracic Surgery

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“…In some patients, infection may develop in those regions of unresolved atelectasis or as a result of unrecognized episodes of aspiration. Atelectasis with postoperative pneumonia has been reported in 7% of 369 patients who underwent lobectomy [18], and in 6.6% of 197 patients who underwent a pneumonectomy [10]. Pneumonia was the cause of death in 1.3% of 598 patients undergoing resection for lung cancer [19].…”

Section: Pathophysiologymentioning

confidence: 99%

Pathogenesis and management of respiratory insufficiency following pulmonary resection

et al. 2000

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“…Amongst them, alveolar air leaks (AAL) and bronchopleural fistulae (BPF) are considered quite challenging in terms of management and lead to prolonged chest tube drainage, LOS and increased risk of pleural infections (2,3).…”

Section: Introductionmentioning

confidence: 99%

The role of BioGlue in thoracic surgery: a systematic review

Tsilimigras

Antonopoulou

Ntanasis‐Stathopoulos

et al. 2017

J. Thorac. Dis.

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Background: BioGlue is a commonly used sealant in thoracic surgery. Prolonged air leak and presence of bronchopleural fistulae (BPF) are often encountered in clinical practice. We therefore, investigated the role and the efficacy of BioGlue in these scenarios.Methods: A systematic review was conducted by searching Medline and Cochrane CentralRegister of Controlled Trials (CENTRAL) [1999][2000][2001][2002][2003][2004][2005][2006][2007][2008][2009][2010][2011][2012][2013][2014][2015][2016] along with reference lists of the included studies.Included studies reported on thoracic surgery operations and use of BioGlue in thoracic surgical procedures, whereas excluded studies met at least one of the following criteria: non-English language studies, nonhuman population, studies on surgical specialties other than Thoracic surgery, reviews and meta-analyses and sealants other than BioGlue.Results: Twelve studies with a total number of 194 patients were included. Amongst them, 178 were treated for alveolar air leaks (AAL), 14 for BPF and 2 for lymphatic leaks. BioGlue was utilized at the time of initial operation in 172 (96.7%) patients for AAL, while at secondary intervention in 13 (92.9%) for BPF and 1 (50%) for lymphatic leak. In terms of AAL, only 2 out of 4 studies showed statistically significant reduction in duration of air leak, duration of intercostal drainage and length of stay (LOS) when BioGlue was applied.No complications were encountered after using BioGlue in sealing BPF, apart from the re-application of BioGlue in 3 cases.Conclusions: Although BioGlue has been shown to be efficient in treating AAL, it should be used with caution against BPF, despite encouraging preliminary results. Potential adverse effects must always be taken into consideration. Future randomized controlled trials are warranted in an attempt to establish its benefit in current clinical practice.

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Elective Pulmonary Lobectomy: Factors Associated with Morbidity and Operative Mortality

Cited by 126 publications

References 14 publications

The Evolution of VATS Lobectomy

The Evolution of VATS Lobectomy

Pathogenesis and management of respiratory insufficiency following pulmonary resection

The role of BioGlue in thoracic surgery: a systematic review

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