Elective single embryo transfer and perinatal outcomes: a systematic review and meta-analysis

Grady, Rosheen; Alavi, N.; Vale, Rachel; Khandwala, Mohammad; McDonald, Sarah D.

doi:10.1016/j.fertnstert.2011.11.033

Cited by 160 publications

(116 citation statements)

References 36 publications

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“…Double ET was a factor that was insignificant for lower LGA rate. Nevertheless, it has been shown, that double ET, in comparison to single ET, results in lower birth weight of IVF singletons [11,47]. The effect of embryo culture length on birth weight still remains a matter of debate.…”

Section: Discussionmentioning

confidence: 99%

Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Korošec

Frangež

Steblovnik

et al. 2015

J Assist Reprod Genet

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Purpose Higher risk for birth of singletons being large for gestational age (LGA) has been revealed after in vitro fertilization (IVF) frozen-thawed embryo-transfer (FET). This phenomenon is now being investigated, since there is a speculation that these neonates could suffer from underlying epigenetic disturbances. The aim of the study was to expose independent LGA risk factors and to identify those connected to the IVF techniques. Methods Altogether, 4508 singleton pregnancies and births were included in the cohort case-matched study. Two hundred eleven singleton pregnancies and births after FET and 916 after fresh embryo transfer (ET) were included into two study groups. The IVF procedures were performed at the University Medical Centre Ljubljana between 2004 and 2011. For each IVF pregnancy, three matched consecutive controls after natural conception were included. Using logistic regression models, we observed LGA connection to maternal parameters (smoking, hypertension, parity, BMI, gestational diabetes, IVF conception, FET, double ET, and ICSI procedure).Results Singletons born after FET had a significantly higher risk for being LGA (p=0.032; OR 1.697; 95 % CI 1.047-2.752). BMI 25-30 was a significant independent risk factor for LGA in the IVF groups (FET p=0.041, OR 2.460, 95 % CI 1.030-5.857 and fresh ET p=0.003; OR 2.188, 95 % CI 1.297-3.691). ICSI and double ET had no significant effect on LGA occurrence. Conclusions Besides maternal BMI, FET is a significant independent LGA risk factor in IVF patients. Other observed factors (smoking, hypertension, multiparity, GDM, ICSI procedure, or number of embryos transferred) do not influence LGA risk significantly.

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Section: Discussionmentioning

confidence: 99%

Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Korošec

Frangež

Steblovnik

et al. 2015

J Assist Reprod Genet

View full text Add to dashboard Cite

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“…Regrettably, data on the Apgar score, neonatal intensive care unit admissions, and perinatal mortality were not available. A recent metaanalysis by Grady et al 15 showed that eSET babies were associated with decreased risks of preterm birth and low birth weight than those involving DET. Moreover, eSET singletons had a higher birth weight and lower preterm birth rate than DET singletons, which was postulated to be related to the vanishing twin.…”

Section: Discussionmentioning

confidence: 99%

Live birth rate, multiple pregnancy rate, and obstetric outcomes of elective single and double embryo transfers: Hong Kong experience

Chai¹,

Yeung²,

Lee³

et al. 2014

Hong Kong Med J

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Objective: To compare the live birth rate, multiple pregnancy rate, and obstetric outcomes of elective single and double embryo transfers.Design: Case series with internal comparisons.Setting: University affiliated hospital, Hong Kong. Participants:Between October 2009 and December 2011, 206 women underwent their first in-vitro fertilisation cycle. Elective single embryo transfer was offered to women who were aged 35 years or below, and had endometrial thickness of 8 mm or more and at least two embryos of good quality. Main outcome measures:Live birth rate, multiple birth rate, and obstetric outcomes.Results: Among the 206 eligible women, 74 underwent an elective single embryo transfer and 132 a double embryo transfer. The live birth rate was comparable in the two groups, being 39.2% in the elective single embryo transfer group and 43.2% in the double embryo transfer group, while the multiple pregnancy rate was significantly lower in the elective single embryo transfer group than the double embryo transfer group (6.9% vs 40.4%; P<0.001). Gestational ages and birth weights were comparable in the two groups. There was no significant difference between

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“…Our experimental design was however modeled to reflect the more common practice of multiple embryo transfer prevalent in US [10]; moreover the studies published using NMR technology used a similar multiple embryo transfer design [18,26].…”

Section: Discussionmentioning

confidence: 99%

1H NMR based profiling of spent culture media cannot predict success of implantation for day 3 human embryos

Rinaudo

Shen

Hua

et al. 2012

J Assist Reprod Genet

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Background Identification of a non-invasive technique to assess embryo implantation potential in assisted reproduction would greatly increase success rates and lead more efficiently to single embryo transfer. Early studies suggested metabonomic analysis of spent culture media could improve embryo selection. The goal of this study is to assess if embryo implantation can be predicted based on proton nuclear magnetic resonance ( 1 H NMR) profiles of spent embryo culture media from patients undergoing transfer of multiple embryos on cycleday 3.Method We conducted a retrospective study in an academic assisted reproduction technology (ART) program and analyzed the data in a university research center. Two hundred twenty-eight spent culture media samples originating from 108 patients were individually analyzed. Specifically, five distinct sets (1 to 5) of different types of spent media samples (volume~14 μL) from embryos that resulted in clinical pregnancy (positive heart rate at 6 weeks gestation) (n 1 029; n 2 0 19; n 3 09; n 4 012; n 5 033; n total 0102) and from embryos that did not implant (n 1 028; n 2 029; n 3 018; n 4 015; n 5 036; n total 0126) were collected on day 3 of embryo growth. The Reprod Genet (2012) 29:1435-1442 DOI 10.1007 media samples were profiled using 1 H NMR spectroscopy, and the NMR profiles of sets 1 to 5 were subject to standard uni-and multi-variate data analyses in order to evaluate potential correlation of profiles with implantation success. Results For set 1 of the media samples, a borderline class separation of NMR profiles was obtained by use of principal component analysis (PCA) and logistic regression. This tentative class separation could not be repeated and validated in any of the other media sets 2 to 5. Conclusions Despite the rigorous technical approach, 1 H NMR based profiling of spent culture media cannot predict success of implantation for day 3 human embryos.

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Elective single embryo transfer and perinatal outcomes: a systematic review and meta-analysis

Cited by 160 publications

References 36 publications

Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Live birth rate, multiple pregnancy rate, and obstetric outcomes of elective single and double embryo transfers: Hong Kong experience

1H NMR based profiling of spent culture media cannot predict success of implantation for day 3 human embryos

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