Elective single embryo transfer: Is frozen better than fresh?

Gomaa, Hala; Baydoun, R.; Sachak, Sakina; Lapana, Ilyn; Soliman, Samuel

doi:10.5935/1518-0557.20160002

Cited by 10 publications

(7 citation statements)

References 32 publications

(33 reference statements)

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“…Our findings are timely given the increasing utilization of FETs 40,41 . Although there are reported benefits 5,8,42,43,44 , if FET increases the risk of preeclampsia [5][6][7][8][9][10] or other adverse outcomes such as macrosomia 8,45 , then its increasing utilization may lead to serious short-and long-term consequences for maternal and child health, and efforts need to be made to reduce risk.…”

Section: Discussionmentioning

confidence: 99%

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum

et al. 2019

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In vitro fertilization involving frozen embryo transfer (FET) and donor oocytes increases preeclampsia risk. These IVF protocols typically yield pregnancies without a corpus luteum (CL), which secretes vasoactive hormones. We investigated whether IVF pregnancies without a CL disrupt maternal circulatory adaptations and increase preeclampsia risk. Women with 0 (n=26), 1 (n=23), or >1 (n=22) CL were serially evaluated before, during and after pregnancy. Because increasing arterial compliance is a major physiological adaptation in pregnancy, we assessed carotid-femoral pulse wave velocity (cfPWV) and transit time (cfPWTT). In a parallel, prospective

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Section: Discussionmentioning

confidence: 99%

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum

et al. 2019

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“…Previous studies have demonstrated similar results for cleavage stage embryos (Bdolah et al ., 2015), but conflicting results have been published regarding blastocyst transfers (Feng et al ., 2012; Doherty et al ., 2014; Özgür et al ., 2015; Gomaa et al ., 2016). …”

Section: Discussionmentioning

confidence: 99%

Embryo stage of development is not decisive for reproductive outcomes in frozen-thawed embryo transfer cycles

Carvalho¹,

Mw²,

Bonesi³

et al. 2017

JBRA Assisted Reproduction

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ObjectiveTo evaluate if the outcomes of IVF/ICSI in frozen-thawed embryo transfer and fresh embryo transfer cycles differ in relation to cleavage and blastocyst stages.MethodsRetrospective cohort study to compare IVF/ICSI outcomes between fresh embryo transfer and frozen-thawed embryo transfer cycles, according to the stage of embryo development. Analysis was carried out on 443 consecutive embryo transfer cycles performed between January 1st and December 31st, 2014. Women aged up to 38 and submitted to embryo transfer cycles with fresh (n = 309) or frozen-thawed (n = 134) embryos at a private center for assistance in human reproduction were considered for analysis. Results in each group were stratified according to the stage of embryo development: cleavage stage and blastocyst stage. Main outcome measures were implantation rate, clinical pregnancy rate, ongoing pregnancy rate and live birth rate per cycle.ResultsIn the fresh embryo transfer group, for cleavage stage versus blastocyst stage, respectively, implantation rates were 22% and 47% (p = 0.0005); clinical pregnancy rates were 34% and 64% (p = 0.0057); the ongoing pregnancy rates were 30% and 61% (p = 0.0046) and live birth rates were 28% and 55% (p = 0.0148). There were no significant differences in the rates between cleavage and blastocyst stages in the frozen-thawed group, neither between fresh and frozen-thawed cleavage embryo transfers nor between fresh and frozen-thawed blastocyst transfers.ConclusionOur results confirm that blastocyst transfer is better than cleavage stage in fresh embryo transfer cycles. In frozen-thawed cycles, cleavage or blastocyst stages seem to offer similar reproductive outcomes.

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“…The extension of the embryo culture at blastocyst stage permits a better embryo selection process [33], because of their post-embryonic genome activation and better development potential [34]. Likewise, numerous studies had indicated higher implantation rates and ongoing pregnancy following frozen-thawed embryo transfer instead of fresh cycles [34][35][36], this strategy increases the synchronization between embryos and the endometrium. Additionally, embryo cryopreservation prevents OHSS and allows a time frame to perform genetic analyses [20].…”

Section: Discussionmentioning

confidence: 99%

Mosaic embryo transfer after oocyte in vitro maturation in combination with non-invasive prenatal testing (NIPT)—first report of a euploid live birth

Inoue¹,

López²,

Delgado

et al. 2017

J Assist Reprod Genet

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Elective single embryo transfer: Is frozen better than fresh?

Abstract: Frozen single embryo transfer was associated with higher pregnancy and live birth rates when compared to fresh single embryo transfer.

Cited by 10 publications

References 32 publications

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum

Embryo stage of development is not decisive for reproductive outcomes in frozen-thawed embryo transfer cycles

Mosaic embryo transfer after oocyte in vitro maturation in combination with non-invasive prenatal testing (NIPT)—first report of a euploid live birth

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