Elective Single-Embryo Transfer versus Double-Embryo Transfer in in Vitro Fertilization

Thurin, Ann; Hausken, Jon; Hillensjø, Torbjörn; Jablonowska, Barbara; Pinborg, Anja; Strandell, Annika; Bergh, Christina

doi:10.1056/nejmoa041032

Cited by 554 publications

(243 citation statements)

References 27 publications

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“…Achieving this shift in clinical practice would be facilitated by a better understanding of factors influencing the use of eSET and the effect of embryo number on cycle outcome. Unfortunately, the evidence is conflicting concerning the effect of SET on pregnancy and live birth rates, with some studies reporting areduction in these rates (37,38), others not (39)(40)(41)(42)(43)(44)(45)(46)(47)(48). Selection of appropriate patients for eSET may be the key in this regard (41,47,48), as well as the ability to choose the best embryos after extended embryo culture (49,50) or better methods to assess embryo quality and viability (51)(52)(53).…”

Section: Discussionmentioning

confidence: 99%

Practice patterns and outcomes with the use of single embryo transfer in the United States

Luke

Brown

Grainger

et al. 2010

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Practice patterns and outcomes with the use of single embryo transfer in the United States

Luke

Brown

Grainger

et al. 2010

Fertility and Sterility

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“…4,5,7,8 To summarise the data, lower clinical pregnancy rates (OR 0.48, 95% CI 0.36-0.63) ( Figure 1) and lower delivery rates (OR 0.51, 95% CI 0.38-0.68) (Figure 2) were demonstrated for eSET. Surprisingly, however, pre-existing retrospective studies did not show this difference in clinical pregnancy rate when comparing eSET with DET (OR 0.91, 95% CI 0.82-1.02) ( Figure 3).…”

Section: -6mentioning

confidence: 98%

“…These results indicate an overall reduction in twin pregnancy rate for eSET (OR 0.02, 95% CI 0.01-0.05) (Figure 4). In four randomised comparisons undertaken in the same period, 3,4,7,8 twin rates ranged from 1.1-10% for eSET and 30-47.4% for DET. By synthesising these data, a significantly higher twin rate was observed in the DET group (OR 0.05, 95% CI 0.02-0.16) ( Figure 5).…”

Section: -6mentioning

confidence: 99%

Elective single embryo transfer

Kosmas

Elst

Devroey

et al. 2008

The Obstetric & Gynaecologis

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Elective single embryo transfer has been implemented in Belgium and Scandinavian countries to decrease the incidence of twin pregnancy and the associated complications. The extra cost associated with achieving an equal number of pregnancies through elective single embryo transfer needs to be considered in the context of any additional neonatal care expenses associated with double embryo transfer. Acceptable ongoing pregnancy and delivery rates have been obtained when comparing single with double embryo transfer. Maternal age, previous attempts, day of embryo transfer and cost should be taken into account. Learning objectives: To understand the issues raised when helping a couple choose single or double embryo transfer. Ethical issues: Where does patient autonomy over treatment end and national regulation begin? The management of obstetric complications and the long‐term sequelae of premature birth should be factored in when considering treatment costs. Please cite this article as: Kosmas I, Van der Elst J, Devroey P, Tournaye H. Elective single embryo transfer. The Obstetrician & Gynaecologist 2008;10:163–169.

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“…[13][14][15][16] However, many couples in Germany are not (yet) willing to have a SET performed. In Germany, the pregnancy rates after a SET, especially in older women, are still significantly lower than those who opt for a transfer of two or three embryos (women aged 25-29 years: 25.21%, 30-34 years: 17.31%, 35-39 years: 14.85%, 40-44 years: 7.22%, 45 years and older: 5.0%; total: 15.0%).…”

Section: Questionsmentioning

confidence: 99%

Organ-Preserving and Reconstructive Microsurgery of the Fallopian Tubes in Tubal Infertility: Still an Alternative to In Vitro Fertilization (IVF)

Schippert

Hille

Bassler

et al. 2010

J reconstr Microsurg

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Tubal infertility mostly results from infections. Conception only is possible through complex treatments (in vitro fertilization or surgery). Success cannot be guaranteed, even after repeated treatments. Unfortunately, many couples are not informed about the prospect for success of tubal reconstruction. Problems of in vitro fertilization are low pregnancy and birth rates of 28.4% and <20% respectively (Germany) and the high number of multiple pregnancies (21%). In this retrospective study 462 women with acquired tubal infertility and further 127 women after previous sterilization underwent microsurgical treatment (microsurgical adhesiolysis, anastomosis, fimbrioplasty, salpingostomy, and refertilization due to former sterilization). The main outcome measures are the pregnancy and birth rates following the microsurgical procedure. Pregnancy and birth rates of 43.4% and 29.2%, respectively, were higher than the outcomes post-single in vitro fertilization (abortion: 6.4%, extrauterine pregnancy: 7.9%). When reversal of sterilization was performed, pregnancy and birth rates were higher at 73% and 50.6%, respectively (abortion: 15.7%, extrauterine pregnancy: 6.7%). The advantages of reconstructive microsurgery over in vitro fertilization include the ideally permanent restoration of woman's ability to conceive naturally (repeated pregnancies are possible without further therapy), a high postoperative birth rate overall, and avoidance of multiple births. It is advisable to inform the patient about the objective possibility of reconstructive tubal surgery.

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Elective Single-Embryo Transfer versus Double-Embryo Transfer in in Vitro Fertilization

Cited by 554 publications

References 27 publications

Practice patterns and outcomes with the use of single embryo transfer in the United States

Practice patterns and outcomes with the use of single embryo transfer in the United States

Elective single embryo transfer

Organ-Preserving and Reconstructive Microsurgery of the Fallopian Tubes in Tubal Infertility: Still an Alternative to In Vitro Fertilization (IVF)

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