Electric moulding of dispersed lipid nanotubes into a nanofluidic device

Frusawa, Hiroshi; Manabe, Tatsuhiko; Kagiyama, Eri; Hirano, Ken; Kameta, Naohiro; Masuda, Mitsutoshi; Shimizu, Toshimi

doi:10.1038/srep02165

Cited by 16 publications

(18 citation statements)

References 54 publications

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“…These FE-SEM images reveal that the CNTs were aligned in parallel to the direction of the applied electric fields. From the adjustment of the SEM focus when observing dry CNT films, we found that the mean CNT film thickness was 5 to 10 μ m [39]. To verify this anisotropy over a larger scale, the alignment degree was quantified using a polarized optical microscope.…”

Section: Anisotropic Properties Of Cnt Micro-clothsmentioning

confidence: 99%

Anisotropic micro-cloths fabricated from DNA-stabilized carbon nanotubes: one-stop manufacturing with electrode needles

Frusawa¹,

Yoshii²

2016

Nano Online

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Section: Anisotropic Properties Of Cnt Micro-clothsmentioning

confidence: 99%

Anisotropic micro-cloths fabricated from DNA-stabilized carbon nanotubes: one-stop manufacturing with electrode needles

Frusawa¹,

Yoshii²

2016

Nano Online

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“…Here, we adopted, as a simpler alternative, one of the electronic tweezers techniques [ 22 , 23 , 33 – 38 ] for on-demand dielectrophoretic assembly and/or manipulation without an optical apparatus (see Fig. 1 ).…”

Section: Introductionmentioning

confidence: 99%

Frequency-Modulated Wave Dielectrophoresis of Vesicles And Cells: Periodic U-Turns at the Crossover Frequency

Frusawa

2018

Nanoscale Res Lett

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We have formulated the dielectrophoretic force exerted on micro/nanoparticles upon the application of frequency-modulated (FM) electric fields. By adjusting the frequency range of an FM wave to cover the crossover frequency fX in the real part of the Clausius-Mossotti factor, our theory predicts the reversal of the dielectrophoretic force each time the instantaneous frequency periodically traverses fX. In fact, we observed periodic U-turns of vesicles, leukemia cells, and red blood cells that undergo FM wave dielectrophoresis (FM-DEP). It is also suggested by our theory that the video tracking of the U-turns due to FM-DEP is available for the agile and accurate measurement of fX. The FM-DEP method requires a short duration, less than 30 s, while applying the FM wave to observe several U-turns, and the agility in measuring fX is of much use for not only salty cell suspensions but also nanoparticles because the electric-field-induced solvent flow is suppressed as much as possible. The accuracy of fX has been verified using two types of experiment. First, we measured the attractive force exerted on a single vesicle experiencing alternating-current dielectrophoresis (AC-DEP) at various frequencies of sinusoidal electric fields. The frequency dependence of the dielectrophoretic force yields fX as a characteristic frequency at which the force vanishes. Comparing the AC-DEP result of fX with that obtained from the FM-DEP method, both results of fX were found to coincide with each other. Second, we investigated the conductivity dependencies of fX for three kinds of cell by changing the surrounding electrolytes. From the experimental results, we evaluated simultaneously both of the cytoplasmic conductivities and the membrane capacitances using an elaborate theory on the single-shell model of biological cells. While the cytoplasmic conductivities, similar for these cells, were slightly lower than the range of previous reports, the membrane capacitances obtained were in good agreement with those previously reported in the literature.Electronic supplementary materialThe online version of this article (10.1186/s11671-018-2583-5) contains supplementary material, which is available to authorized users.

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“…Compared to the conventional microfluidic channel, the analyte molecules in solution tend to interact with the surface groups at the nanochannel wall, since the analyte molecules are confined in the tiny spaces of the nanochannels. Therefore, various pre-treatment chips have been recently developed that are constructed with nanofluidic channels 4 5 6 7 8 9 10 . In order to form nanofluidic channels, top-down fabrication methods have been tried by either mask-less sculpting with focused ion beam (FIB) or masked dry-etching with electron beam (EB) lithography.…”

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Mesoporous-silica nanofluidic channels for quick enrichment/extraction of trace pesticide molecules

Chen

2015

Sci Rep

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As nanofluidic channels, uniaxially oriented mesoporous-silica is, for the first time, in-situ self-assembled in a microfluidic chip for quick enrichment/extraction of ng L−1(ppt)-level organo-phosphorous (OP) pesticide residue from aqueous solution to ethanol. This micro/nano combined pre-treatment chip is essential for following gas chromatography-mass spectrometry (GC-MS) quantitative analysis. Featuring huge surface area and dense silanol groups at the inwall surface, the mesoporous-silica is uniaxially self-assembled in a micro-reservoir to form a pile of nanofluidic channels (diameter = 2.1 nm). The captured/enriched pesticide molecules in the nanochannels can be efficiently extracted by much smaller volume of ethanol due to its much higher solubility to OP. In our affirming experiment, three mixed OP pesticides of dichlorvos, paraoxon and chlorpyrifos (in water) are captured/enriched by the nano-channels and eluted/extracted by only 0.6 mL ethanol. The whole process only takes 16 min. The GC-MS quantitative results for the extracted three pesticides indicate that the extraction recovery achieves 80%. The achieved limit of quantification (LOQ) and the limit of detection (LOD) are 100 ng L−1 and 30 ng L−1, respectively. The nanofluidic-channel pre-treatment technique is promising in various application fields like agriculture and food safety security.

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Electric moulding of dispersed lipid nanotubes into a nanofluidic device

Cited by 16 publications

References 54 publications

Anisotropic micro-cloths fabricated from DNA-stabilized carbon nanotubes: one-stop manufacturing with electrode needles

Anisotropic micro-cloths fabricated from DNA-stabilized carbon nanotubes: one-stop manufacturing with electrode needles

Frequency-Modulated Wave Dielectrophoresis of Vesicles And Cells: Periodic U-Turns at the Crossover Frequency

Mesoporous-silica nanofluidic channels for quick enrichment/extraction of trace pesticide molecules

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