Electric Plasma–generated Nitric Oxide: Hemodynamic Effects in Patients with Pulmonary Hypertension

Rodriguez-Lopez, Josanna; Rezoagli, Emanuele; Yu, Binglan; Fisher, Daniel F.; Semigran, Marc J.; Bloch, Donald B.; Channick, Richard N.; Zapol, Warren M.

doi:10.1164/rccm.201604-0834le

Cited by 18 publications

(12 citation statements)

References 5 publications

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“…Berra and colleagues tested the NO generator on six healthy volunteers and six patients with chronic pulmonary hypertension (Berra et al ., 2016). Each subject received 25 p.p.m.…”

Section: Generating No From Air Using Pulsed Electrical Dischargesmentioning

confidence: 99%

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Inhaled nitric oxide

Ichinose

Bloch

et al. 2018

British J Pharmacology

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Nitric oxide (NO) is a gas that induces relaxation of smooth muscle cells in the vasculature. Because NO reacts with oxyhaemoglobin with high affinity, the gas is rapidly scavenged by oxyhaemoglobin in red blood cells and the vasodilating effects of inhaled NO are limited to ventilated regions in the lung. NO therefore has the unique ability to induce pulmonary vasodilatation specifically in the portions of the lung with adequate ventilation, thereby improving oxygenation of blood and decreasing intrapulmonary right to left shunting. Inhaled NO is used to treat a spectrum of cardiopulmonary conditions, including pulmonary hypertension in children and adults. However, the widespread use of inhaled NO is limited by logistical and financial barriers. We have designed, developed and tested a simple and economic NO generation device, which uses pulsed electrical discharges in air to produce therapeutic levels of NO that can be used for inhalation therapy. Linked Articles This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc

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“…Berra and colleagues tested the NO generator on six healthy volunteers and six patients with chronic pulmonary hypertension (Berra et al ., 2016). Each subject received 25 p.p.m.…”

Section: Generating No From Air Using Pulsed Electrical Dischargesmentioning

confidence: 99%

“…of NO for 10 min, and no adverse effects were detected. In six patients with chronic pulmonary hypertension, the acute pulmonary vasodilator haemodynamic effects of electrically generated NO were similar to those seen using NO obtained from commercially available cylinders (Berra et al ., 2016).…”

Section: Generating No From Air Using Pulsed Electrical Dischargesmentioning

confidence: 99%

Inhaled nitric oxide

Ichinose

Bloch

et al. 2018

British J Pharmacology

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“…In a proof-of-concept human study, we examined the effects of breathing electrically generated NO in six healthy volunteers and six patients with chronic pulmonary hypertension. (47) Our data suggest that the synthesis and testing of electrically generated NO in a hospital setting were safe. No adverse effects were observed in the six healthy volunteers breathing 25 ppm NO in air for 10 minutes.…”

Section: No For the Treatment Of Pulmonary Hypertensionmentioning

confidence: 71%

Pulmonary Delivery of Therapeutic and Diagnostic Gases

Zapol

Charles

Sá

et al. 2018

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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The 21st Congress for the International Society for Aerosols in Medicine included, for the first time, a session on Pulmonary Delivery of Therapeutic and Diagnostic Gases. The rationale for such a session within ISAM is that the pulmonary delivery of gaseous drugs in many cases targets the same therapeutic areas as aerosol drug delivery, and is in many scientific and technical aspects similar to aerosol drug delivery. This article serves as a report on the recent ISAM congress session providing a synopsis of each of the presentations. The topics covered are the conception, testing, and development of the use of nitric oxide to treat pulmonary hypertension; the use of realistic adult nasal replicas to evaluate the performance of pulsed oxygen delivery devices; an overview of several diagnostic gas modalities; and the use of inhaled oxygen as a proton magnetic resonance imaging (MRI) contrast agent for imaging temporal changes in the distribution of specific ventilation during recovery from bronchoconstriction. Themes common to these diverse applications of inhaled gases in medicine are discussed, along with future perspectives on development of therapeutic and diagnostic gases.

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“…In a previous study, we designed, developed, and tested a simple and economic NO generation device, which uses a pulsed electrical discharge between iridium electrodes to produce NO from air [27]. After scavenging of potentially toxic gas byproducts and filtration to remove metallic particles, the electrically generated NO can provide safe and effective treatment of pulmonary hypertension [27; 28].…”

Section: Introductionmentioning

confidence: 99%