Electrical activity of the heart

Morega, Alexandru M.; Morega, Mihaela; Dobre, Adrian

doi:10.1016/b978-0-12-817897-3.00004-x

Cited by 2 publications

(1 citation statement)

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“…Ion channels have several functions in the body, but one of the most important is in the cardiovascular system, where the passage of potassium, sodium, and calcium ions across cardiomyocytes is essential for maintaining a regular heart rhythm. In order to provide mechanistic insight into a range of electrophysiological processes, computational simulations and mathematical modeling have shown to be quite beneficial (Morega et al, 2021, Clerx et al, 2019, Bertram et al, 2016. Ion channel mathematical models are essential components of these AP models.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study of Ion Current Estimation by Artificial Neural Network from Action Potential Waveforms

Ayan

Süleymanoğlu

Özdoğan

2022

Preprint

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Experiments using conventional experimental approaches to capture the dynamics of ion channels are not always feasible, and even when possible and feasible, some can be time-consuming. In this work, the ionic current-time dynamics during cardiac action potentials (APs) are predicted from a single AP waveform by means of artificial neural networks (ANNs). The data collection is accomplished by the use of a single-cell model to run electrophysiological simulations in order to identify ionic currents based on fluctuations in ion channel conductance. The relevant ionic currents, as well as the corresponding cardiac AP, are then calculated and fed into the ANN algorithm, which predicts the desired currents solely based on the AP curve. The validity of the proposed methodology for the Bayesian approach is demonstrated by the R (validation) scores obtained from training data, test data, and the entire data set. The Bayesian regularization's (BR) strength and dependability are further supported by error values and the regression presentations, all of which are positive indicators. As a result of the high convergence between the simulated currents and the currents generated by including the efficacy of a developed Bayesian solver, it is possible to generate behavior of ionic currents during time for the desired AP waveform for any electrical excitable cell.

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Section: Introductionmentioning

confidence: 99%