Electrical carotid sinus stimulation may get lost in translation

Jordan, Jens; Tank, Jens

doi:10.1038/s41440-020-0522-1

Cited by 1 publication

(2 citation statements)

References 17 publications

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“…Affecting baroreceptor with preserved cardiovascular regulation mechanisms, magnetic field generates improvement in a spectrum of genuine baroreceptor functions including normalization of low blood pressure, heart rate variability, and microcirculation [Gmitrova and Gmitrov, 1990; Gmitrov et al, 1990; Gmitrov 1996, 2014, 2015, 2020]. This specific hemodynamic response suggested that SMF activates baroreceptors, and enhanced the important arterial baroreflex blood pressure regulation feed back mechanisms, which are actually abolished by baroreceptor electric stimulation technique [Jordan and Tank, 2020]. The absence of magnets' direct contact with carotid sinus excluded carotid nerve damage and the chemoreceptor sympathetic excitatory effect, which actually counteracts baroreceptor activation and is possible by baroreceptor electric stimulation [Katayama et al, 2015; Jordan and Tank, 2020].…”

Section: Discussionmentioning

confidence: 99%

“…This specific hemodynamic response suggested that SMF activates baroreceptors, and enhanced the important arterial baroreflex blood pressure regulation feed back mechanisms, which are actually abolished by baroreceptor electric stimulation technique [Jordan and Tank, 2020]. The absence of magnets' direct contact with carotid sinus excluded carotid nerve damage and the chemoreceptor sympathetic excitatory effect, which actually counteracts baroreceptor activation and is possible by baroreceptor electric stimulation [Katayama et al, 2015; Jordan and Tank, 2020].…”

Section: Discussionmentioning

confidence: 99%

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Carotid Baroreceptor Magnetic Activation and Beat‐to‐Beat Blood Pressure Variability, Implications to Treat Abrupt Blood Pressure Elevation in Labile Hypertension

Gmitrov

2022

Bioelectromagnetics

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Mounting evidence suggests enhanced blood pressure (BP) variability (BPV) independent role in cardiovascular (CV) damage. The goal was to estimate the effect of the carotid baroreceptor (CB) magnetic stimulation on sudden high BP elevation. Mean femoral arterial BP (MAP), heart rate (HR), baroreflex sensitivity (BRS), and ear lobe skin microcirculatory blood flow, by microphotoelectric plethysmography (MPPG), were simultaneously recorded in conscious rabbits sedated by pentobarbital intravenous (i.v.) infusion (5 mg/kg/h) after 40 min CB exposure to 350 mT static magnetic field (SMF), by Nd 2 -Fe 14 -B magnets (n = 14), or sham magnets exposure (n = 14). BRS was assessed from HR and MAP responses to abrupt hypotension induced by i.v. bolus injections of nitroprusside (Ni) and abrupt MAP elevation (MAP AE ) by i.v. bolus of phenylephrine (Ph). Beat-tobeat BPV was estimated by MAP standard deviation. SMF CB exposure significantly increased BRS Ni (74.5 ± 17.8%, P < 0.001) and microcirculation (23.8% ± 11.0%, P = 0.039); decreased MAP (−5.7 ± 1.7%, P < 0.014) and phenylephrine-induced MAP AE (−19.1%, P = 0.043). MAP AE positively correlated with resting MAP (r = 0.342, P = 0.0383) and MAP SD (r = 0.383, P = 0.0194), and inversely with BRS Ph (r = −0.47, P = 0.0156). SMF CB exposure enhanced the nitroprusside, which acts by releasing nitric oxide (NO), vasodilatory effect. This indicates arterial baroreflex to improve vessel sensitivity to NO, which is a new physiology with BP buffering effect. A positive correlation of MAP SD to phenylephrine BP ramps suggests a causal relationship and BPV prognostic significance to forecast abrupt BP elevation. Mechano/baroreceptor magnetosensing property proposed to be the basic physiology by which SMFs boost CV autonomic regulation with potential implementation in high CV risk labile arterial hypertensive disease. Bioelectromagnetics. 43:413-425, 2022.

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