This continuous downsizing has brought numerous advantages but also relevant challenges, coming hand-in-hand with the conception of novel and varied applications. [3][4][5][6] Among them, biosensing and bioelectronic applications have been successfully explored [7,8] , e.g., employing functionalized specific biomarkers on SiFETs surface, enabling selective label-free detection. [9,10] Silicon has also been utilized for numerous in vitro recordings of electrogenic cells (cardiac or neural) or even in vivo mapping of the whole brain. [11,12] However, it is known to be a bioresorbable material that degrades over time once immersed in saline, thus, suffering from a limited operation time for in vivo applications. [13,14] While silicon still dominates the industrial semiconductor scene, a new material has emerged rather recently, transforming materials science: graphene. Accompanied by other two-dimensional (2D) materials, graphene has already opened new prospects in modern nanoelectronic applications [15][16][17][18] and also holds a great promise for bio-and neuroapplications due to its extraordinary conductivity and good biocompatibility. [19][20][21] In particular, graphene-based FETs (GFETs) and microelectrode arrays (MEAs), both rigid and flexible, have been reported to successfully interface with electrogenic cellsThe combination of graphene and silicon in hybrid electronic devices has attracted increasing attention over the last decade. Here, a unique technology of graphene-on-silicon heterostructures as solution-gated transistors for bioelectronics applications is presented. The proposed graphene-onsilicon field-effect transistors (GoSFETs) are fabricated by exploiting various conformations of channel doping and dimensions. The fabricated devices demonstrate hybrid behavior with features specific to both graphene and silicon, which are rationalized via a comprehensive physics-based compact model which is purposely implemented and validated against measured data. The developed theory corroborates that the device hybrid behavior can be explained in terms of two independent silicon and graphene carrier transport channels, which are, however, strongly electrostatically coupled. Although GoSFET transconductance and carrier mobility are found to be lower than in conventional silicon or graphene field-effect transistors, it is observed that the combination of both materials within the hybrid channel contributes uniquely to the electrical response. Specifically, it is found that the graphene sheet acts as a shield for the silicon channel, giving rise to a nonuniform potential distribution along it, which impacts the transport, especially at the subthreshold region, due to non-negligible diffusion current.