The wear of induction cladded coating during motion was investigated through the abrasive mass at a speed of 1.0 to 3.0 m/s and the impact angle of abrasive particles with a worn surface of 0° to 90°. Cladding was performed by using Ni-Cr-Si-B-Fe flame spraying powder. Experimental research was carried out by using the Response Surface Method (RSM) and Central Composite Design (CCD). Analysis of variance proved that both motion speed and impact angle had significant impact on the wear of coating, both individually and interactively. Motion speed had the greatest influence, and the interaction of speed and angle had the least influence. The wear rate increased along with the motion speed increase, and the influence of the impact angle depends on the wear speed. At a speed of 1 m/s, the wear increases along with the increase of angle from 0° to 45° and then continues to decrease up to the angle of 90°. At a speed of 2 m/s, the wear increases along with the angle increase from 0° to 30° and then continues to decrease up to the angle of 90°. At a speed of 3 m/s, the wear increases along with the angle increase from 0° to 20° and then decreases as the angle increases up to 90°. Based on the statistical data processing, this research developed the mathematical model of wear in the form of quadratic polynomial that describes the influences of input variables in individual and interactive form.