Electrical modeling of pulsed power systems for biomedical applications

Wijetunga, P.; Gu, Xianyue; Vernier, T.; Kuthi, A.; Behrend, Matthew R.; Gundersen, M.A.

doi:10.1109/ppc.2003.1277742

Cited by 7 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traditionally, coaxial transmission line-based implementations, such as Blumlein, in correlation with spark-gap, Marx bank or diode opening switch techniques have been used to generate high-voltage nanosecond-pulses [33][34][35][36]. These techniques can produce pulses with very high amplitude (voltages in excess of 5kV), short durations (widths varying from 1ns to 300ns), with fast rise time (< 2ns).…”

Section: Methodsmentioning

confidence: 99%

Push–pull configuration of high-power MOSFETs for generation of nanosecond pulses for electropermeabilization of cells

Davies¹,

Merla

Casciati

et al. 2019

Int. J. Microw. Wireless Technol.

View full text Add to dashboard Cite

A power MOSFET-based push–pull configuration nanosecond-pulse generator has been designed, constructed, and characterized to permeabilize cells for biological and medical applications. The generator can deliver pulses with durations ranging from 80 ns up to 1 µs and pulse amplitudes up to 1.4 kV. The unit has been tested for in vitro experiments on a medulloblastoma cell line. Following the exposure of cells to 100, 200, and 300 ns electric field pulses, permeabilization tests were carried out, and viability tests were conducted to verify the performance of the generator. The maximum temperature rise of the biological load was also calculated based on Joule heating energy conservation and experimental validation. Our results indicate that the developed device has good capabilities to achieve well-controlled electro-manipulation in vitro.

show abstract

Section: Methodsmentioning

confidence: 99%

Push–pull configuration of high-power MOSFETs for generation of nanosecond pulses for electropermeabilization of cells

Davies¹,

Merla

Casciati

et al. 2019

Int. J. Microw. Wireless Technol.

View full text Add to dashboard Cite

show abstract

“…To demonstrate the validity of the LWR norms established here, and their effectiveness in regard to pulse tailoring, we now apply it to an example of a PPBL intended for some biomedical applications [19][20][21][22].…”

Section: Example: Improvement Of the Pulse Shape And Durationmentioning

confidence: 99%

“…In [22], the PPBL was initially designed to create a 5-ns pulse, which was successfully done, as shown in Figure 11. Evidently, the pulse has a regular shape and it is in agreement with the theoretical prediction.…”

Section: Example: Improvement Of the Pulse Shape And Durationmentioning

confidence: 99%

“…[Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.] Next, the authors in [22] wanted to create a 1-ns pulse. To do that, they adequately shortened the BL length, according to Eq.…”

Section: Example: Improvement Of the Pulse Shape And Durationmentioning

confidence: 99%

“…2) in Figure 13a, whereas the red curve (No. 1) is the original pulse from [22] that we reconstructed by our computer model. The noticeable effects are: shorter rise/fall time, shorter pulse duration, which from 1.55 ns now dropped to 1.35 ns, and the pulse did reach its maximum value.…”

Section: Example: Improvement Of the Pulse Shape And Durationmentioning

confidence: 99%

See 2 more Smart Citations

Limitations to compacting a parallel-plate Blumlein pulse-forming line

Joler¹,

Christodoulou²,

Schamiloglu³

2008

Int J RF and Microwave Comp Aid Eng

View full text Add to dashboard Cite

For the applications of compact pulsed-power systems, we propose a model for optimizing the pulse-forming line (PFL) with respect to the optimum pulse generation. There are multiple parameters that play important and conflicting roles in the design of a PFL. The original notion that a pulse, of a desired duration, can be created and the length of the line shortened by using a dielectric with sufficiently high permittivity, is shown here to be overly simplified, and that it can lead to a deformed pulse instead. In this work, new criteria for successful pulse formation are proposed and their validity demonstrated.

show abstract