Electrical signals guided entrapment and controlled release of antibiotics on titanium surface

Shi, Xiaowen; Wu, Haoran; Li, Yuanyuan; Wei, Xiao-Quan; Du, Yumin

doi:10.1002/jbm.a.34432

Cited by 34 publications

(16 citation statements)

References 26 publications

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“…In addition, strong forces such as covalent binding are insufficiently sensitive to react to weak external stimuli [133]. To overcome these issues, combinations of antibiotics with other compounds have been proposed either alone or in association with a particular mechanism of controlled release [196]. …”

Section: Basic Concepts Of Antibacterial Coatingmentioning

confidence: 99%

Antibacterial Surface Treatment for Orthopaedic Implants

Gallo

Holinka

Moucha

2014

IJMS

295

203

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It is expected that the projected increased usage of implantable devices in medicine will result in a natural rise in the number of infections related to these cases. Some patients are unable to autonomously prevent formation of biofilm on implant surfaces. Suppression of the local peri-implant immune response is an important contributory factor. Substantial avascular scar tissue encountered during revision joint replacement surgery places these cases at an especially high risk of periprosthetic joint infection. A critical pathogenic event in the process of biofilm formation is bacterial adhesion. Prevention of biomaterial-associated infections should be concurrently focused on at least two targets: inhibition of biofilm formation and minimizing local immune response suppression. Current knowledge of antimicrobial surface treatments suitable for prevention of prosthetic joint infection is reviewed. Several surface treatment modalities have been proposed. Minimizing bacterial adhesion, biofilm formation inhibition, and bactericidal approaches are discussed. The ultimate anti-infective surface should be “smart” and responsive to even the lowest bacterial load. While research in this field is promising, there appears to be a great discrepancy between proposed and clinically implemented strategies, and there is urgent need for translational science focusing on this topic.

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Section: Basic Concepts Of Antibacterial Coatingmentioning

confidence: 99%

Antibacterial Surface Treatment for Orthopaedic Implants

Gallo

Holinka

Moucha

2014

IJMS

295

203

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“…In fact, despite the theoretical advantages for non-eluting systems, this concept is limited by the fragility of the coatings and killing activity potential of bacteria which might not be directly adjacent to the implant. To overcome these issues, combinations of antibiotics with other compounds have been proposed either alone or in association with a particular mechanism of controlled release [ 84 ]. Antibiotics such as gentamicin, vancomycin, and others have been loaded into porous hydroxyapatite (HA) coatings on titanium implants.…”

Section: Classification Of Antibacterial Coating Technologiesmentioning

confidence: 99%

Antibacterial coating of implants in orthopaedics and trauma: a classification proposal in an evolving panorama

et al. 2015

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Implanted biomaterials play a key role in current success of orthopedic and trauma surgery. However, implant-related infections remain among the leading reasons for failure with high economical and social associated costs. According to the current knowledge, probably the most critical pathogenic event in the development of implant-related infection is biofilm formation, which starts immediately after bacterial adhesion on an implant and effectively protects the microorganisms from the immune system and systemic antibiotics. A rationale, modern prevention of biomaterial-associated infections should then specifically focus on inhibition of both bacterial adhesion and biofilm formation. Nonetheless, currently available prophylactic measures, although partially effective in reducing surgical site infections, are not based on the pathogenesis of biofilm-related infections and unacceptable high rates of septic complications, especially in high-risk patients and procedures, are still reported.In the last decade, several studies have investigated the ability of implant surface modifications to minimize bacterial adhesion, inhibit biofilm formation, and provide effective bacterial killing to protect implanted biomaterials, even if there still is a great discrepancy between proposed and clinically implemented strategies and a lack of a common language to evaluate them.To move a step forward towards a more systematic approach in this promising but complicated field, here we provide a detailed overview and an original classification of the various technologies under study or already in the market. We may distinguish the following: 1. Passive surface finishing/modification (PSM): passive coatings that do not release bactericidal agents to the surrounding tissues, but are aimed at preventing or reducing bacterial adhesion through surface chemistry and/or structure modifications; 2. Active surface finishing/modification (ASM): active coatings that feature pharmacologically active pre-incorporated bactericidal agents; and 3. Local carriers or coatings (LCC): local antibacterial carriers or coatings, biodegradable or not, applied at the time of the surgical procedure, immediately prior or at the same time of the implant and around it. Classifying different technologies may be useful in order to better compare different solutions, to improve the design of validation tests and, hopefully, to improve and speed up the regulatory process in this rapidly evolving field.

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“…Electrodeposition of chitosan hydrogel on titanium plates was carried out by using a conventional two-electrode system as described previously [26]. The working electrode was a titanium plate with a size of 1.5 × 3.5 cm 2 and the reference electrode was a platinum wire.…”

Section: Electrodeposition Of Chitosan Hydrogel On Titanium Platesmentioning

confidence: 99%

“…Strong noncovalent bonds such as hydrogen bonds and hydrophobic interactions are responsible for the generation of chitosan hydrogel. Various biocomponents such as proteins [21][22][23], cells [24,25], antibiotics [26], and nanocomponents [27] can be entrapped in the porous network of the deposited chitosan hydrogel. The above work demonstrates the capability of electrodeposited chitosan as drug reservoir and the potential for controlled drug release.…”

Section: Introductionmentioning

confidence: 99%

Electrical Signal Guided Ibuprofen Release from Electrodeposited Chitosan Hydrogel

Liu

Yan

Jiang

et al. 2014

International Journal of Polymer Science

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Electrical signal guided drug release from conductive surface provides a simple and straightforward way for advanced drug delivery. In this study, we investigated the ibuprofen release from electrodeposited chitosan hydrogel by applying electrical signals. Specifically, chitosan hydrogel was electrodeposited on titanium plate and used as a matrix for ibuprofen load and release. The release of ibuprofen from the chitosan hydrogel on titanium plate was pH sensitive. By applying a positive or negative electrical potential, the release rate of ibuprofen from the electrodeposited chitosan can be facilely controlled. Thus, coupling chitosan electrodeposition and electrical signal control spurs new possibilities for biopolymeric coating and drug elution on conductive implants.

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Electrical signals guided entrapment and controlled release of antibiotics on titanium surface

Cited by 34 publications

References 26 publications

Antibacterial Surface Treatment for Orthopaedic Implants

Antibacterial Surface Treatment for Orthopaedic Implants

Antibacterial coating of implants in orthopaedics and trauma: a classification proposal in an evolving panorama

Electrical Signal Guided Ibuprofen Release from Electrodeposited Chitosan Hydrogel

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