Electrical Stimulation of Monkey Brain With Various Frequencies and Pulse Durations

Mihailović, L; Delgado, José M. R.

doi:10.1152/jn.1956.19.1.21

Cited by 107 publications

(15 citation statements)

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“…The exact nature of the anticonvulsant action elicited by electrical stimulation is not fully understood. The stimulation parameters that are anticonvulsant are consistent with parameters previously shown to be at or near those maximally effective for extracellular stimulation of subcortical and cortical neurons (Mihailovic and Delgado, 1956). Therefore, electrical stimulation of MN probably resulted in depolarizations of neurons and possibly axons of passage in the vicinity of the electrodes at the rate of the stimulation frequency.…”

Section: Discussionsupporting

confidence: 85%

Electrical Stimulation of the Mammillary Nuclei Increases Seizure Threshold to Pentylenetetrazol in Rats

1994

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High-frequency electrical stimulation of mammillary nuclei (MN) of rat posterior hypothalamus resulted in a significant increase in seizure threshold induced by pentylenetetrazol (PTZ). The anticonvulsant effect was frequency and intensity specific. Stimulation at 100 Hz (1-5 V, 30-200 microA) afforded protection against EEG and behavioral manifestations of PTZ seizures. Stimulation of either low frequency (5 Hz), high intensities (8-20 V, 300-800 microA), or outside the histologically verified MN target region did not increase seizure threshold. In some instances, high-intensity stimulation of MN alone elicited spike-wave epileptiform EEG activity accompanied by either arrest of behavior or myoclonic seizures. In animals with ongoing seizure activity, electrical stimulation of MN disrupted the high-voltage synchronous wave forms on cortical EEG. These data support the concept that electrical perturbation of MN in hypothalamus may functionally inhibit generalization of paroxysmal activity required for expression of the EEG and, in particular, the behavioral component of PTZ seizures. These studies provide additional insight into forebrain-brainstem interactions mediating generalized seizure expression.

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Section: Discussionsupporting

confidence: 85%

Electrical Stimulation of the Mammillary Nuclei Increases Seizure Threshold to Pentylenetetrazol in Rats

1994

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“…Stimulation of the so-called sympathetic hypothalamic area of Hess during the posterior hypothalamotomy for aggressiveness induces ipsilateral mydriasis, sweating, piloerection, vasoconstriction, and increase in blood pressure. 27,56 The frequency-dependency of pupillar dilation, with electrodes in the lateral hypothalamus, has been studied in detail, 57 showing a curve identical to that of the frequency dependency of tremor in Vim DBS. 58 On the contrary to stimulation, lesions in the subthalamic area can induce an ipsilateral Horner syndrome.…”

Section: Descending Sympathetic Fibersmentioning

confidence: 99%

Postoperative management of subthalamic nucleus stimulation for Parkinson's disease

et al. 2002

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Abstract:The postoperative neurologic management of patients with deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson' s disease is a complex dynamic process that involves a progressive increase in stimulation intensity and a parallel decrease in antiparkinsonian medication while assessing the interactions of both treatments. Neurologists responsible for postoperative management of patients receiving STN DBS must have expert knowledge of the electroanatomy of the subthalamic area and be familiar with the medical treatment of motor and nonmotor symptoms, including the management of long-term complications of levodopa treatment. Neurosurgeons who perform DBS need to understand the principles that guide the postoperative adaptation of treatment. This article defines guidelines for setting stimulation parameters, adapting drugs and managing adverse effects.

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“…Stimulation of the so‐called sympathetic hypothalamic area of Hess during the posterior hypothalamotomy for aggressiveness induces ipsilateral mydriasis, sweating, piloerection, vasoconstriction, and increase in blood pressure 27, 56. The frequency‐dependency of pupillar dilation, with electrodes in the lateral hypothalamus, has been studied in detail,57 showing a curve identical to that of the frequency dependency of tremor in Vim DBS 58. On the contrary to stimulation, lesions in the subthalamic area can induce an ipsilateral Horner syndrome 59–63.…”

Section: Management Of Adverse Effectsmentioning

confidence: 96%

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Babb¹

2002

Cathet Cardio Intervent

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Electrical Stimulation of Monkey Brain With Various Frequencies and Pulse Durations

Cited by 107 publications

References 0 publications

Electrical Stimulation of the Mammillary Nuclei Increases Seizure Threshold to Pentylenetetrazol in Rats

Electrical Stimulation of the Mammillary Nuclei Increases Seizure Threshold to Pentylenetetrazol in Rats

Postoperative management of subthalamic nucleus stimulation for Parkinson's disease

Better information, better communication

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