Electrical stimulation of paralyzed vibrissal muscles reduces endplate reinnervation and does not promote motor recovery after facial nerve repair in rats

Sinis, Nektarios; Horn, Frauke; Genchev, Borislav; Skouras, Emmanouil; Merkel, Daniel R.; Angelova, Srebrina K.; Kaidoglou, Katerina; Michael, Joern; Pavlov, Stoyan; Igelmund, Peter; Schaller, Hans-Eberhard; Irintchev, Andrey; Dunlop, Sarah; Angelov, Doychin N.

doi:10.1016/j.aanat.2009.03.004

Cited by 51 publications

(41 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In animal experiment models, Sapmaz et al (21) reported the severity of axonal degeneration of the facial nerve correlated with the frequency of electrical stimulation of the facial musculature. This observation was corroborated by Sinis et al (22) who noted that the number of innervated motor endplates in experimental rat models was reduced to approximately 20% of control animals receiving sham stimulation and also failed to reduce the proportion of poly-innervated motor endplates. Muscles maintained in good tone by electrical stimulation will fail to release neurotrophic growth factors needed to receive the regenerating facial nerve to the facial musculature.…”

Section: Discussionsupporting

confidence: 81%

A National Survey of Facial Paralysis on the Quality of Life of Patients with Acoustic Neuroma

Leong

Lesser

2015

Otology &Amp; Neurotology

View full text Add to dashboard Cite

Facial paralysis is a significant problem in patients with acoustic neuroma. Based on this survey, treatment for facial paralysis is often not offered and even when given, still leaves the patient with a significantly lowered quality of life. However, it should be remembered that this study has surveyed a skewed patient population and that overall, most acoustic neuroma patients do not suffer with facial paralysis.

show abstract

Section: Discussionsupporting

confidence: 81%

A National Survey of Facial Paralysis on the Quality of Life of Patients with Acoustic Neuroma

Leong

Lesser

2015

Otology &Amp; Neurotology

View full text Add to dashboard Cite

show abstract

“…Electrical stimulation as a therapeutic in nerve injuries has been widely discussed in the academic community [305][306][307][308][309][310][311][312][313]. External electrical stimulation as peripheral nerve regeneration strategy has been demonstrated.…”

Section: Conductive Conduitsmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

View full text Add to dashboard Cite

Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

show abstract

“…Because previous studies have shown no significant age-related differences in withdrawal latency to thermal 39 and mechanical 34 stimuli in adult rats, the end point of sham-operated rats was determined at 5 weeks postoperatively. In addition, as part of unpublished experiments, we examined 3 sham-operated rats mainly for possible age-related changes in histological data, as well as behavioral changes, at 30 weeks postoperatively.…”

Section: 41mentioning

confidence: 99%

Long-term follow-up of peptidergic and nonpeptidergic reinnervation of the epidermis following sciatic nerve reconstruction in rats

Kambiz

Duraku

Baas

et al. 2015

JNS

View full text Add to dashboard Cite

OBJECT Peripheral nerve injuries are a commonly encountered clinical problem and often result in long-term functional deficits. The current gold standard for transected nerves is an end-to-end reconstruction, which results in the intermittent appearance of neuropathic pain. METHODS To improve our understanding of the relation between this type of reconstruction and neuropathic pain, the authors transected and immediately end-to-end reconstructed the sciatic nerve in rats. The effect of this procedure on neuropathic pain, as measured by thermal and mechanical hypersensitivity at 4 different time points (5, 10, 20, and 30 weeks), was related to the density of peptidergic and nonpeptidergic fiber innervation in the glabrous skin of rats' hind paws. RESULTS Thermal hypersensitivity occurring 20 weeks after reconstruction was accompanied by a significant increase in peptidergic epidermal fibers. However, the lesion-induced reduction in the density of nonpeptidergic epidermal fibers remained decreased at all experimental time points. Moreover, temporal collateral sprouting by undamaged saphenous nerve was visualized using the recently revised Evans blue extravasation technique. Strikingly, as the sciatic nerve repopulated rats' hind paw, the saphenous nerve withdrew to its original territory. CONCLUSIONS The authors conclude that the transient thermal hypersensitivity is related to increased density of epidermal peptidergic fibers, which mainly originate from regenerating fibers. Furthermore, a changed composition in the peptidergic and nonpeptidergic epidermal fibers is demonstrated following end-to-end reconstruction of the sciatic nerve.

show abstract

Electrical stimulation of paralyzed vibrissal muscles reduces endplate reinnervation and does not promote motor recovery after facial nerve repair in rats

Cited by 51 publications

References 71 publications

A National Survey of Facial Paralysis on the Quality of Life of Patients with Acoustic Neuroma

A National Survey of Facial Paralysis on the Quality of Life of Patients with Acoustic Neuroma

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Long-term follow-up of peptidergic and nonpeptidergic reinnervation of the epidermis following sciatic nerve reconstruction in rats

Contact Info

Product

Resources

About