2022
DOI: 10.1096/fasebj.2022.36.s1.r5295
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Electrical Stimulation of the Dorsal Motor Nucleus of the Vagus Attenuates Serum Pro‐Inflammatory Cytokine Levels in Murine Models of Endotoxemia and Sepsis

Abstract: The inflammatory reflex is a vagus nerve‐mediated and brainstem‐integrated physiological mechanism that regulates immunity and inflammation (Annu Rev Immunol, 2018, 36:783). The efferent vagus nerve originates in brainstem nuclei, including the dorsal motor nucleus of the vagus (DMN). Recently, it was shown that optogenetic stimulation of cholinergic DMN neurons inhibits serum TNF levels during endotoxemia (Proc Natl Acad Sci USA, 2020, 117(47):29803). However, the effects of electrical DMN stimulation on cyto… Show more

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“…Despite these anatomical studies, functional studies remain conflicting. Some argue that direct electrical stimulation of DMV does not change chronotropy (Geis and Wurster, 1980; Laughton and Powley, 1987), while others demonstrate local activation (chemical, electrical, optogenetic, or chemogenetic) elicits bradycardias even if only modestly (Falvey et al, 2023; Machhada et al, 2020; Machhada et al, 2016; Sporton et al, 1991; Thompson et al, 2023). However, no activation technique in awake animals used to date rules out incidental stimulation of either neighboring nucleus tractus solitarius (NTS) neurons or inhibitory interneurons within DMV.…”
Section: Introductionmentioning
confidence: 99%
“…Despite these anatomical studies, functional studies remain conflicting. Some argue that direct electrical stimulation of DMV does not change chronotropy (Geis and Wurster, 1980; Laughton and Powley, 1987), while others demonstrate local activation (chemical, electrical, optogenetic, or chemogenetic) elicits bradycardias even if only modestly (Falvey et al, 2023; Machhada et al, 2020; Machhada et al, 2016; Sporton et al, 1991; Thompson et al, 2023). However, no activation technique in awake animals used to date rules out incidental stimulation of either neighboring nucleus tractus solitarius (NTS) neurons or inhibitory interneurons within DMV.…”
Section: Introductionmentioning
confidence: 99%