1987
DOI: 10.1016/0304-3940(87)90717-8
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Electrical stimulations of perifused magnocellular nuclei in vitro elicit Ca2+-dependent, tetrodotoxin-insensitive release of oxytocin and vasopressin

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Cited by 86 publications
(39 citation statements)
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“…In contrast, the lack of effect of TTX on peptide release within the nuclear region suggests that this intranuclear pool is not derived from synaptic terminals. This finding is support ed by results which demonstrate that electrically induced VP and OT release from isolated magnocellular regions was not altered by TTX pretreatment [17].…”
Section: Discussionsupporting
confidence: 79%
“…In contrast, the lack of effect of TTX on peptide release within the nuclear region suggests that this intranuclear pool is not derived from synaptic terminals. This finding is support ed by results which demonstrate that electrically induced VP and OT release from isolated magnocellular regions was not altered by TTX pretreatment [17].…”
Section: Discussionsupporting
confidence: 79%
“…However, release from dendrites can occur wholly independently of spike activity [43]. Stimulation of the neural stalk triggers antidromic action potentials in magnocellular neurons, but does not normally release oxytocin within the SON [43]; in vitro, only strong stimulation (100 Hz) of afferents or stimulation with long depolarizing pulses (10 ms pulses) produces significant dendritic release [42,44]. However, some peptides [45] can trigger dendritic release without any direct increase in spike activity and without any oxytocin release into plasma.…”
Section: Dendritic Release Of Oxytocinmentioning
confidence: 99%
“…2) Although experimental evidence from in vitro or electronmicroscopic studies is missing, OXT may directly act at the dendritic level to locally inhibit exocytotic processes related to AVP release. A dissociation of dendritic release and the electrical activity of neuropeptidergic neurons has been established (11,36). 3) Alternatively, OXT could modulate excitatory or inhibitory inputs to AVP neurons identified preor postsynaptically within the SON (7,8; for a review, see Ref.…”
Section: Discussionmentioning
confidence: 99%
“…It demonstrates the ability of neuronal cells to independently regulate neuropeptide release from various neuronal elements (axon terminals vs. dendrites and somata). With respect to dendritic release, it has been revealed that intrahypothalamic neuropeptide release can occur independently of the electrical activity (11,36), which is required for axonal neuropeptide secretion. Furthermore, locally released neurotransmitters/neuromodulators, including AVP itself (21,63), GABA (17,28,29) and taurine (15,26,52) were recently considered to regulate basal and stimulated activity of neurohypophyseal AVP (and also OXT) neurons and, thus, AVP secretion into blood.…”
mentioning
confidence: 99%