Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome

Pappone, Carlo; Brugada, Josép; Vicedomini, Gabriele; Ciconte, Giuseppe; Manguso, Francesco; Saviano, Massimo; Vitale, Raffaele; Cuko, Amarild; Giannelli, Luigi; Ćalović, Žarko; Conti, Manuel; Pozzi, Paolo; Natalizia, Andrea; Crisà, Simonetta; Borrelli, Valeria; Brugada, Ramón; Sarquella-Brugada, Geòrgia; Guazzi, Marco; Frigiola, Alessandro; Menicanti, Lorenzo; Santinelli, Vincenzo

doi:10.1161/circep.117.005053

Cited by 208 publications

(188 citation statements)

References 31 publications

Supporting

Mentioning

175

Contrasting

Unclassified

Order By: Relevance

“…It is also important to appreciate that channelopathies causing Brugada syndrome can lead to RV structural abnormalities and the substrate for VT and ventricular fibrillation (VF). Specifically, epicardial RVOT interstitial fibrosis and reduced connexin‐43 expression are thought to contribute to the basis of the arrhythmogenic substrate . A new entity identified in high endurance athletes describes pathological RV remodeling and localized subepicardial RVOT scar that serves as the substrate for rapid VT …”

Section: Introductionmentioning

confidence: 99%

“…Specifically, epicardial RVOT interstitial fibrosis and reduced connexin-43 expression are thought to contribute to the basis of the arrhythmogenic substrate. [5][6][7] A new entity identified in high endurance athletes describes pathological RV remodeling and localized subepicardial RVOT scar that serves as the substrate for rapid VT. 8 This review will focus its attention on the more rarefied spectrum of sustained RV tachycardias that are focal in origin ( Table 2).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mechanistic subtypes of focal right ventricular tachycardia

Lerman

Cheung

et al. 2018

Cardiovasc electrophysiol

View full text Add to dashboard Cite

Idiopathic sustained focal right ventricular tachycardia (VT) is most frequently due to outflow tract (OT) tachycardia. This arrhythmia is recognized by its characteristic ECG pattern and sensitivity to adenosine. However, there are other forms of idiopathic, focal sustained VT that originate from the right ventricle (RV), which are less well appreciated and easily overlooked. This review will identify the characteristic features and electrophysiologic properties of these forms of RV VT, including those originating from the tricuspid annulus, right ventricular papillary muscles, and moderator band as well as variants of classic RVOT tachycardia and those due to microreentry in the presence of preclinical disease. Recognition of these subtypes of focal RV tachycardia should facilitate targeted therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanistic subtypes of focal right ventricular tachycardia

Lerman

Cheung

et al. 2018

Cardiovasc electrophysiol

View full text Add to dashboard Cite

show abstract

“…After flecainide, the low‐voltage epicardial areas expanded and the duration of abnormal electrograms increased in almost all patients, facilitating localization and subsequent ablation of abnormal substrates, which in many patients extended from the RVOT toward the anterior aspect of the RV free wall. In the largest series published so far, Pappone et al also showed similar results using 3D mapping, confirming the importance of epicardial substrate . Furthermore, in his report only two of 27 patients with frequent appropriate ICD discharges had recurrences postablation.…”

Section: Chapter 12: Inherited Primary Arrhythmias Syndromementioning

confidence: 99%

2019 APHRS expert consensus statement on three‐dimensional mapping systems for tachycardia developed in collaboration with HRS, EHRA, and LAHRS

Kim

Chen

Ernst

et al. 2020

Journal of Arrhythmia

View full text Add to dashboard Cite

“…Initial work in patients with electrical storm proved to be effective in controlling VAs during follow‐up in eight of nine patients 63 . More recently, identification and elimination of the arrhythmic electrophysiological substrate has been performed to potentially eliminate the arrhythmias seen in BrS 64,65 …”

Section: Long‐term Management and Prognosismentioning

confidence: 99%

Atrial fibrillation in Brugada syndrome: Current perspectives

Vlachos

Mascia

Martin

et al. 2020

Cardiovasc electrophysiol

View full text Add to dashboard Cite

The incidence of atrial fibrillation (AF) in Brugada syndrome (BrS) has been reported at between 9% and 53% by different series, but the true prevalence is unknown. However, AF may be the presenting feature in some patients. The underlying mechanisms for AF may be a combination of multiple factors, genetic or acquired, that may impact upon autonomic function, atrial structure, and conduction velocities or other unknown factors. The presence of AF has been associated with a more malignant course, with a greater incidence of syncope and ventricular arrhythmias, thus acting as marker of more advanced disease. Regarding the management of patients with AF, antiarrhythmic drugs effective in preventing malignant arrhythmias in BrS such as quinidine or invasive treatment with pulmonary vein isolation (PVI) may be useful in AF treatment. In this review, we aim to present the current perspectives regarding the genetics, pathophysiology, management, and prognosis of AF in patients with BrS.

show abstract

Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome

Abstract: URL: https://clinicaltrials.gov. Unique identifier: NCT02641431.

Cited by 208 publications

References 31 publications

Mechanistic subtypes of focal right ventricular tachycardia

Mechanistic subtypes of focal right ventricular tachycardia

2019 APHRS expert consensus statement on three‐dimensional mapping systems for tachycardia developed in collaboration with HRS, EHRA, and LAHRS

Atrial fibrillation in Brugada syndrome: Current perspectives

Contact Info

Product

Resources

About