Electrically conductive hydrogel-based micro-topographies for the development of organized cardiac tissues

Navaei, Ali; Moore, Nathan Allen; Sullivan, Ryan; Truong, Danh D.; Migrino, Raymond Q.; Nikkhah, Mehdi

doi:10.1039/c6ra26279a

Cited by 79 publications

(46 citation statements)

References 64 publications

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“…ECHs deliver biomimetic topographical and electrical cues in vitro to form highly oriented cellular constructs with tissue-level functionality (d). [181] conductive materials from inherently non-conductive polymers, through the conjugation of a choline-based Bio-IL [20]. Our results demonstrated that GelMA/Bio-IL ECHs could be used to modulate the proliferation and contractile function of primary rat CMs in vitro.…”

Section: Tissue Engineeringmentioning

confidence: 74%

“…In another study by Navaei et al, 50 m microgrooves were incorporated into gelatin GelMA hydrogels with electrically conductive GNRs (Fig. 9d) [181]. Fluorescent images revealed uniform, dense, and highly aligned cellular organization, as well as enhanced cytoskeletal alignment and cellular connectivity.…”

Section: Tissue Engineeringmentioning

confidence: 79%

“…More recently, Navaei et al described a technique for micropatterning CMs onto ECHs by incorporating conductive GNRs into GelMA hydrogels to create microgrooved architectures [181]. Their approach utilized a micro-mold composed of PDMS with a microgrooved topography.…”

Section: Micropatterning Of Echsmentioning

confidence: 99%

“…Live cells were stained in green, while dead CMs were stained in red, confirming high cell viability after 7 days of cell culture. [181] Schematic of supramolecular organic-inorganic composite capable of self-healing via interactions between oligomer chains (pink lines) with micro nickel and urea groups (blue and purple shapes) (d). Representative stress-strain curves for ECHs containing 31% micro nickel volume ratio under different healing conditions showing that healing efficiency was found to be a function of time (e).…”

Section: Self-assembly / Self-healingmentioning

confidence: 99%

See 3 more Smart Citations

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Walker

Portillo-Lara

Mogadam

et al. 2019

Progress in Polymer Science

167

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Electroconductive hydrogels (ECHs) are highly hydrated three-dimensional (3D) networks generated through the incorporation of conductive polymers, nanoparticles, and other conductive materials into polymeric hydrogels. ECHs combine several advantageous properties of inherently conductive materials with the highly tunable physical and biochemical properties of hydrogels. Recently, the development of biocompatible ECHs has been investigated for various biomedical applications, such as tissue engineering, drug delivery, biosensors, flexible electronics, and other implantable medical devices. Several methods for the synthesis of ECHs have been reported, which include the incorporation of electrically conductive materials such as gold and silver nanoparticles, graphene, and carbon nanotubes, as well as various conductive polymers (CPs), such as polyaniline, polypyrrole, and poly(3,4-ethylenedioxyythiophene) into hydrogel networks. These electroconductive composite hydrogels can be used as scaffolds with high swellability, tunable mechanical properties, and the capability to support cell growth both in vitro and in vivo. Furthermore, recent advancements in microfabrication techniques such as 3D bioprinting, micropatterning, and electrospinning have led to the development of ECHs with biomimetic microarchitectures that reproduce the characteristics of the native extracellular matrix (ECM). The combination of sophisticated synthesis chemistries and modern microfabrication techniques have led to engineer smart ECHs with advanced architectures, geometries, and functionalities that are being increasingly used in drug delivery systems, biosensors, tissue engineering, and soft electronics. In this review, we will summarize different strategies to synthesize conductive biomaterials. We will also discuss the advanced microfabrication techniques used to fabricate ECHs with complex 3D architectures, as well as various biomedical applications of microfabricated ECHs.

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Section: Tissue Engineeringmentioning

confidence: 74%

Section: Tissue Engineeringmentioning

confidence: 79%

Section: Micropatterning Of Echsmentioning

confidence: 99%

Section: Self-assembly / Self-healingmentioning

confidence: 99%

See 2 more Smart Citations

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Walker

Portillo-Lara

Mogadam

et al. 2019

Progress in Polymer Science

167

View full text Add to dashboard Cite

show abstract

“…Nanomaterials such as carbon nanotubes (CNTs) (Martinelli et al, 2012;Patel et al, 2016), gold (Au) nanorods (Fleischer et al, 2014;Navaei et al, 2016Navaei et al, , 2017Shin et al, 2016), graphene oxide (GO) nanoflakes (Shevach et al, 2013;Park et al, 2015a), silicon nanowires (Park et al, 2015b;Tan et al, 2017), and iron oxide (Han et al, 2015;Richards et al, 2016) in conjugation with the extracellular and intercellular microenvironments of transplanted cells are believed to enable regeneration of injured CMs Amezcua et al, 2016;Mehrali et al, 2017). Regenerative properties of CMs can be measured by obtaining electrical conductivity, protein adsorption affinity, intracellular signaling pathways, and magnetic properties.…”

Section: Cardiac Tementioning

confidence: 99%

State-of-Art Functional Biomaterials for Tissue Engineering

2019

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Nanobiotechnology-enabled tissue engineering strategies have emerged as an innovative and promising technique in the field of regenerative medical science. The design and development of multifunctional smart biomaterials compatible to human physiology is crucial to achieve the required biological function with a reduced negative biological response. Several medical bioimplants have been tested to boost life expectancy and better-quality life. The concept of biocompatibility focuses on body acceptance and no harmful effects after implantation, which require shaping the properties of materials synthesis, surface functionalization, and biofunctionality. Such developed bioactive and biodegradable materials have been utilized to achieve the required function at a specific period and sustainability to withstand the surrounding tissues for treating severe injuries and diseases. Thus, exploring new approaches to design multifunctional biocompatible advanced nanostructures to develop next-generation therapies for tissue engineering, this mini-review is an attempt to summarize the advancements in biofunctional smart materials. The review focuses on bio-mimic materials, biomaterials, self-assembly biomaterials, bioprinting functional hydrogels, new polymeric architectures, and hybrid synthetic-natural hydrogels in the field of tissue engineering and regenerative medicine (TERM). This mini-review will serve as a guideline to design future research where the selection of a smart multifunctional biomaterial is crucial to obtain best TERM performance.

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Spatiotemporally Controlled Photoresponsive Hydrogels: Design and Predictive Modeling from Processing through Application

Zhu

Yang

et al. 2020

Adv Funct Materials

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Photoresponsive hydrogels (PRHs) are soft materials whose mechanical and chemical properties can be tuned spatially and temporally with relative ease. Both photo‐crosslinkable and photodegradable hydrogels find utility in a range of biomedical applications that require tissue‐like properties or programmable responses. Progress in engineering with PRHs is facilitated by the development of theoretical tools that enable optimization of their photochemistry, polymer matrices, nanofillers, and architecture. This review brings together models and design principles that enable key applications of PRHs in tissue engineering, drug delivery, and soft robotics, and highlights ongoing challenges in both modeling and application.

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Electrically conductive hydrogel-based micro-topographies for the development of organized cardiac tissues

Abstract: In this study, we developed conductive microgrooved tissue constructs, leading to the formation of highly packed and uniaxially oriented cardiac cytoarchitecture.

Cited by 79 publications

References 64 publications

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Rational design of microfabricated electroconductive hydrogels for biomedical applications

State-of-Art Functional Biomaterials for Tissue Engineering

Spatiotemporally Controlled Photoresponsive Hydrogels: Design and Predictive Modeling from Processing through Application

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