Electrically conductive nanofibrous scaffolds based on poly(ethylene glycol)s-modified polyaniline and poly(ε-caprolactone) for tissue engineering applications

Hatamzadeh, Maryam; Najafi-Moghadam, Peyman; Beygi‐Khosrowshahi, Younes; Massoumi, Bakhshali; Jaymand, Mehdi

doi:10.1039/c6ra22280c

Cited by 31 publications

(16 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These parameters, corrosion potential (E corr ) and corrosion current density (i corr ), characterized the electrochemical behavior of the investigated samples and are presented in Table 2. The polarization resistance (R p ) was calculated using the Stern-Geary equation [63]:…”

Section: Coating Degradation Behaviormentioning

confidence: 99%

Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions

et al. 2020

View full text Add to dashboard Cite

Our study focused on the long-term degradation under simulated conditions of coatings based on different compositions of polycaprolactone-polyethylene glycol blends (PCL-blend-PEG), fabricated for titanium implants by a dip-coating technique. The degradation behavior of polymeric coatings was evaluated by polymer mass loss measurements of the PCL-blend-PEG during immersion in SBF up to 16 weeks and correlated with those yielded from electrochemical experiments. The results are thoroughly supported by extensive compositional and surface analyses (FTIR, GIXRD, SEM, and wettability investigations). We found that the degradation behavior of PCL-blend-PEG coatings is governed by the properties of the main polymer constituents: the PEG solubilizes fast, immediately after the immersion, while the PCL degrades slowly over the whole period of time. Furthermore, the results evidence that the alteration of blend coatings is strongly enhanced by the increase in PEG content. The biological assessment unveiled the beneficial influence of PCL-blend-PEG coatings for the adhesion and spreading of both human-derived mesenchymal stem cells and endothelial cells.

show abstract

Section: Coating Degradation Behaviormentioning

confidence: 99%

Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In neural tissue engineering, chitosan–gelatin scaffolds doped with conductive hyaluronic acid-poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles were shown to enhance neural stem cell proliferation and differentiation into neurons and astrocytes . Researchers have also explored polyaniline , and polypyrrole , to endow neural tissue engineering scaffolds with conductive properties. In cardiac tissue engineering, conductive scaffolds could be used to electrophysiologically mature human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).…”

Section: Introductionmentioning

confidence: 99%

Electrospun Carbon Nanotube-Based Scaffolds Exhibit High Conductivity and Cytocompatibility for Tissue Engineering Applications

et al. 2022

View full text Add to dashboard Cite

Carbon nanotubes (CNTs) are known for their excellent conductive properties. Here, we present two novel methods, “sandwich” (sCNT) and dual deposition (DD CNT), for incorporating CNTs into electrospun polycaprolactone (PCL) and gelatin scaffolds to increase their conductance. Based on CNT percentage, the DD CNT scaffolds contain significantly higher quantities of CNTs than the sCNT scaffolds. The inclusion of CNTs increased the electrical conductance of scaffolds from 0.0 ± 0.00 kS (non-CNT) to 0.54 ± 0.10 kS (sCNT) and 5.22 ± 0.49 kS (DD CNT) when measured parallel to CNT arrays and to 0.25 ± 0.003 kS (sCNT) and 2.85 ± 1.12 (DD CNT) when measured orthogonally to CNT arrays. The inclusion of CNTs increased fiber diameter and pore size, promoting cellular migration into the scaffolds. CNT inclusion also decreased the degradation rate and increased hydrophobicity of scaffolds. Additionally, CNT inclusion increased Young’s modulus and failure load of scaffolds, increasing their mechanical robustness. Murine fibroblasts were maintained on the scaffolds for 30 days, demonstrating high cytocompatibility. The increased conductivity and high cytocompatibility of the CNT-incorporated scaffolds make them appropriate candidates for future use in cardiac and neural tissue engineering.

show abstract

“…Of the mentioned polyaniline forms, green polyaniline salt is of particular interest with respect to medical applications. Within the biomedical field, this conducting polymer can be used, for example, in scaffolds for bone regeneration [ 2 ], tissue engineering [ 3 ], regenerative medicine [ 4 ], or biosensing [ 5 , 6 ]. With regard to morphology, polyaniline can be prepared in different forms as well [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Critical Factors Limiting Polyaniline Biocompatibility

et al. 2019

View full text Add to dashboard Cite

Today, the application of polyaniline in biomedicine is widely discussed. However, information about impurities released from polyaniline and about the cytotoxicity of its precursors aniline, aniline hydrochloride, and ammonium persulfate are scarce. Therefore, cytotoxicity thresholds for the individual precursors and their combinations were determined (MTT assay) and the type of cell death caused by exposition to the precursors was identified using flow-cytometry. Tests on fibroblasts revealed higher cytotoxicity of ammonium persulfate than aniline hydrochloride. Thanks to the synergic effect, both monomers in combination enhanced their cytotoxicities compared with individual substances. Thereafter, cytotoxicity of polyaniline doped with different acids (sulfuric, nitric, phosphoric, hydrochloric, and methanesulfonic) was determined and correlated with impurities present in respective sample (HPLC). The lowest cytotoxicity showed polyaniline doped with phosphoric acid (followed by sulfuric, methanesulfonic, and nitric acid). Cytotoxicity of polyaniline was mainly attributed to the presence of residual ammonium persulfate and low-molecular-weight polar substances. This is crucial information with respect to the purification of polyaniline and production of its cytocompatible form.

show abstract

Electrically conductive nanofibrous scaffolds based on poly(ethylene glycol)s-modified polyaniline and poly(ε-caprolactone) for tissue engineering applications

Abstract: The objective of this study was to design and development of electrically conductive nanofibrous scaffolds composed of PEGs-b-(PANI)4 and PCL for tissue engineering applications.

Cited by 31 publications

References 46 publications

Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions

Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions

Electrospun Carbon Nanotube-Based Scaffolds Exhibit High Conductivity and Cytocompatibility for Tissue Engineering Applications

Exploring the Critical Factors Limiting Polyaniline Biocompatibility

Contact Info

Product

Resources

About