Electrically controlled drug delivery system using polyelectrolyte gels

Sawahata, K.; Hara, M.; Yasunaga, Hidekazu; Osada, Yoshihito

doi:10.1016/0168-3659(90)90165-p

Cited by 127 publications

(65 citation statements)

References 14 publications

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“…In the case of calcium alginate gels, the Ca 2+ ions, which were used for cross-linking, and H 3 O + ions, which were generated in the alginate gels, moved toward the cathode, 26,27,30 and the water from the outside entered into the alginate gels. Therefore, the calcium alginate gel near the anode decreased in size, and the calcium alginate gel near the cathode increased in size.…”

Section: Evaluation Of the Stimulus Response S Obara Et Almentioning

confidence: 99%

Evaluation of the stimulus response of hydroxyapatite/ calcium alginate composite gels

Obara

Yamauchi

Tsubokawa

2010

Polym J

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Stimuli-responsive gels have been actively studied and applied to a variety of devices such as drug carriers, artificial muscles and actuators. In this research study, calcium alginate gels containing hydroxyapatite were prepared in one step by adding a diammonium hydrogenphosphate-1% alginate solution to a calcium chloride solution and evaluated for pH dependence and electrochemical properties as stimuli-responsive gels. When the composite gel was immersed in a solution of pH 2-10 or subjected to an applied voltage, the composite gel with a high content of hydroxyapatite tended to maintain its volume. The composite gels immersed in a pH indicator solution changed color with an applied voltage. As a result, it was revealed that alteration of the pH of composite gels occurred by electro-osmosis and electrophoresis. Swelling and shrinking of the composite gels were controlled by the external stimuli of pH, voltage and the content of hydroxyapatite; therefore, it is proposed that composite gels would be good bone-filling material having the function of drug carriers.

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Section: Evaluation Of the Stimulus Response S Obara Et Almentioning

confidence: 99%

Evaluation of the stimulus response of hydroxyapatite/ calcium alginate composite gels

Obara

Yamauchi

Tsubokawa

2010

Polym J

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“…An abrupt volumetric change is expected for this purpose because it is induced by such controllable parameters as temperature, pH, additives concentration, electrical field and so on (Ishihara et al, 1984;Hoffman et al, 1986;Bae et al, 1987;Sawahata et al, 1990;Dong and Hoffman, 1991;Baker and Siegel, 1996;Kaneko et al, 1997;Sahoo et al, 1998;Park, 1999;Ebara et al, 2001). For instance, Nisopropylacrylamide (NIPAAm)/butyl methacrylate (BMA) gel was used to control the release rate of indomethacin by the abrupt swelling/shrinkage induced by temperature changes (Bae et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Brownian Dynamics Simulation Study of Self-Diffusion of a Charged Particle in Swollen Counter-Charged Hydrogel Modeled as Cubic Lattice.

Miyata

Endo

Ohmori

et al. 2002

J. Chem. Eng. Japan

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The tracer diffusion of a charged particle in an oppositely charged cubic lattice as a simplest model of charged hydrogel was studied by a Brownian dynamics simulation. The effect of the electrostatic attractive interaction between the tracer particle and the cubic lattice on the self-diffusion coefficient was mainly discussed, when the mesh size of the cubic lattice was sufficiently larger than the diameter of the particle. The charge density of the cubic lattice structure and the electrolyte concentration in the solvent were varied. The electrostatic force acting on the tracer particle was calculated using the potential screened by an electric double layer. The self-diffusion coefficient of the tracer particle significantly decreases as the charge density of the cubic lattice increases, while the increase in the electrolyte concentration in the solvent induces the disappearance of the effect of electrostatic attractive interaction on the self-diffusion coefficient, resulting into the asymptotical behavior to those observed in the non-charged cubic lattice. 2-Order reduction in the self-diffusion coefficient was obtained in this simulation and this shows the applicability of the control of diffusivity of ionic solutes in the swollen hydrogel by means of introducing ionic species covalently into the hydrogels. In the spatial distribution of the probability density of the charged tracer particle, the stochastic path along which the tracer particle tends to move was observed in the charged cubic lattice, which is caused by electrostatic potentials. The reduction of the self-diffusion coefficient in the charged cubic lattice is due to the transient entrapment at the point of local minimum of potential energy inside the stochastic paths.

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“…As a result, hydrogel material facing the cathode displayed more prominent swelling than the side facing the anode. Another example is the use of Poly(acrylic acid) (PAA) hydrogel microsphere as a drug delivery system [89,90] . PAA hydrogel microspheres showed rapid and sharp shrinkage when electric field was applied, due to electroosmosis and electrophoresis.…”

Section: Electric Field Responsive Hydrogelmentioning

confidence: 99%

Smart hydrogels for 3D bioprinting

Wang¹,

Lee²,

Yeong³

2024

IJB

149

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Hydrogels are 3D networks that have a high water content. They have been widely used as cell carriers and scaffolds in tissue engineering due to their structural similarities to the natural extracellular matrix. Among these, "Smart" hydrogels refer to a group of hydrogels that is responsive to various external stimuli such as pH, temperature, light, electric, and magnetic field. Combining the potential of 3D printing and smart hydrogels is an exciting new paradigm in the fabrication of a functional 3D tissue. In this article, we provide a state-of-the-art review on smart hydrogels and bioprinting. We identify the critical material properties needed for the most commonly used bioprinting techniques, namely extrusion-based, inkjet-based, and laser-based techniques. The latest progress in different smart hydrogel systems and their applications in bioprinting are presented. The challenges of printing these hydrogel systems are also highlighted. Lastly, we present the potentials and the future perspectives of smart hydrogels in 3D bioprinting.

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Electrically controlled drug delivery system using polyelectrolyte gels

Cited by 127 publications

References 14 publications

Evaluation of the stimulus response of hydroxyapatite/ calcium alginate composite gels

Evaluation of the stimulus response of hydroxyapatite/ calcium alginate composite gels

Brownian Dynamics Simulation Study of Self-Diffusion of a Charged Particle in Swollen Counter-Charged Hydrogel Modeled as Cubic Lattice.

Smart hydrogels for 3D bioprinting

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